Plasma polymerized carvone as an antibacterial and biocompatible coating

Nanocomposites offer attractive and cost-effective thin layers with superior properties for antimicrobial, drug delivery and microelectronic applications. This work reports single-step plasma-enabled synthesis of polymer/zinc nanocomposite thin films via co-deposition of renewable geranium essential oil-derived polymer and zinc nanoparticles produced by thermal decomposition of zinc acetylacetonate. The chemical composition, surfaces characteristics and antimicrobial performance of the designed nanocomposite were systematically investigated. XPS survey proved the presence of ZnO in the matrix of formed polymers at 10 W and 50 W. SEM images verified that the average size of a ZnO nanoparticle slightly increased with an increase in the power of deposition, from approximately 60 nm at 10 W to approximately 80 nm at 50 W. Confocal scanning laser microscopy images showed that viability of S. aureus and E.coli cells significantly reduced on surfaces of ZnO/polymer composites compared to pristine polymers. SEM observations further demonstrated that bacterial cells incubated on Zn/Ge 10 W and Zn/Ge 50 W had deteriorated cell walls, compared to pristine polymers and glass control. The release of ZnO nanoparticles from the composite thin films was confirmed using ICP measurements, and can be further controlled by coating the film with a thin polymeric layer. These eco-friendly nanocomposite films could be employed as encapsulation coatings to protect relevant surfaces of medical devices from microbial adhesion and colonization.

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“…as biocompatible and antimicrobial surfaces) and electronics (e.g. as layers in superior organic and hybrid devices) 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly nanocomposites derived from geranium oil and zinc oxide in one step approach

Al-Jumaili

Mulvey

Kumar

et al. 2019

Sci Rep

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“…Then, samples were exposed to a 2% (v/v) glutaraldehyde solution in distilled water, rinsed with phosphate-buffered saline (PBS) to remove nonadherent bacteria, and fixed with ethanol solutions (35%, 50%, 70%, 80%, 90%, and 100% v/v in distilled water). [28] Posteriorly, samples were sputtercoated with gold and analyzed using SEM to evaluate bacterial attachment on their surfaces.…”

Section: Bacterial Attachmentmentioning

confidence: 99%

“…Antibacterial coatings have been obtained by plasma-enhanced chemical vapor deposition (PECVD) using plant secondary metabolites such as essential oils and extracts as precursors. [25][26][27][28] However, this route requires the use of vacuum systems, thereby increasing the cost for commercial applications. An alternative would be the use of atmospheric plasma systems, but the volatility of essential oil compounds makes retention of bioactive functional groups in the resultant coating a demanding task.…”

mentioning

confidence: 99%

Antibacterial coatings on vegetable ivory obtained by cold plasma jet activation of silicone and copaiba oils

Silva

Queiroz

Kling

et al. 2020

Plasma Processes & Polymers

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Vegetable ivory obtained from the endosperm of jarina seeds (Phytelephas macrocarpa), native to the Amazon region, has been regarded as a sustainable alternative to elephant ivory; however, it is vulnerable to biodegradation due to its mannan polysaccharide composition. In this study, vegetable ivory was coated by atmospheric air plasma jet activation of silicone and copaiba oils. Stable, smooth, and crosslinked micrometric coatings were formed after 80 s of plasma activation. Water contact angle results show that hydrophobicity was enhanced without detrimental effects on the surface reflectance. The best antibacterial performance against Staphylococcus aureus and Escherichia coli was obtained for a 1:1 mixture of both oils due to the synergetic action of silicone hydrophobicity and copaiba bioactivity.

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“…The α,β-unsaturated ketone system in carvone is generally expected to be responsible for the high enzyme-inducing action [143]. Recently, Chan et al, (2016) fabricated polymer coatings resultant from plasma polymerization of carvone [144]. At an input power of 10 W, carvone polymerized coatings demonstrated almost equal antimicrobial performance against both Gram-negative and Gram-positive bacteria (86% decrease in E. coli and 84% reduction in S. aureus ), with no cytotoxic effect towards primary human endothelial cells.…”

Section: The Antibacterial Activities Of Psmsmentioning

confidence: 99%

“…The antimicrobial activities of these films included antibiofouling effects and/or bactericidal actions (e.g., membrane distortion, pores creation, and membrane damage). The SEM images are reproduced with permission from [137,144,153].…”

Section: Figurementioning

confidence: 99%

Plant Secondary Metabolite-Derived Polymers: A Potential Approach to Develop Antimicrobial Films

et al. 2018

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The persistent issue of bacterial and fungal colonization of artificial implantable materials and the decreasing efficacy of conventional systemic antibiotics used to treat implant-associated infections has led to the development of a wide range of antifouling and antibacterial strategies. This article reviews one such strategy where inherently biologically active renewable resources, i.e., plant secondary metabolites (PSMs) and their naturally occurring combinations (i.e., essential oils) are used for surface functionalization and synthesis of polymer thin films. With a distinct mode of antibacterial activity, broad spectrum of action, and diversity of available chemistries, plant secondary metabolites present an attractive alternative to conventional antibiotics. However, their conversion from liquid to solid phase without a significant loss of activity is not trivial. Using selected examples, this article shows how plasma techniques provide a sufficiently flexible and chemically reactive environment to enable the synthesis of biologically-active polymer coatings from volatile renewable resources.

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Plasma polymerized carvone as an antibacterial and biocompatible coating

Cited by 53 publications

References 50 publications

Eco-friendly nanocomposites derived from geranium oil and zinc oxide in one step approach

Eco-friendly nanocomposites derived from geranium oil and zinc oxide in one step approach

Antibacterial coatings on vegetable ivory obtained by cold plasma jet activation of silicone and copaiba oils

Plant Secondary Metabolite-Derived Polymers: A Potential Approach to Develop Antimicrobial Films

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