Plasma plasminogen activator inhibitor-1 in angina pectoris. Influence of plasma insulin and acute-phase response.

Juhan‐Vague, I.; Alessi, Marie‐Christine; Joly, Patrick; Thirion, Xavier; Vague, P; Declerck, Paul; Serradimigni, A; Collen, D.

doi:10.1161/01.atv.9.3.362

Cited by 207 publications

(78 citation statements)

References 29 publications

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“…Plasma fibrinolytic activity has been shown to be modulated by inflammation in vivo [5]. In agreement with this fact, D-D levels decreased in the pleural space after quinacrine instillation used to cause inflammation and fibrin deposition in treatment of malignant effusions by pleurodesis [4].…”

mentioning

confidence: 72%

Fibrinolytic and inflammatory processes in pleural effusions

Philip-Joët¹,

Alessi²,

Philip-Joet³

et al. 1995

Eur Respir J

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103

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F Fi ib br ri in no ol ly yt ti ic c a an nd d i in nf fl la am mm ma at to or ry y p pr ro oc ce es ss se es s i in n p pl le eu ur ra al l e ef ff fu us si io on ns s F. Philip-Joët*, M-C. Alessi**, C. Philip-Joët**, M. Aillaud**, J-R. Barriere*, A. Arnaud*, I. Juhan-Vague** Sixty patients with pleural effusion were studied. The underlying aetiology was empyema in 10 cases, tuberculosis in 9, cancer in 31, cardiac failure in 7, and undetermined in 3. Plasminogen, plasminogen activator inhibitor 1 (PAI-1) and 2 (PAI-2), tissue type plasminogen activator (t-PA), urokinase (u-PA) and D-dimers (D-D) were quantified in plasma samples and pleural effusion specimens. These data were then correlated with inflammatory or infectious parameters, i.e. fibrinogen, von Willebrand factor (vWF), erythrocyte sedimentation rate (ESR), protein concentration, and white blood cell count.D-D levels were higher in pleural fluid than in plasma. D-D levels were not correlated with either plasminogen activator or plasminogen activator inhibitor levels, suggesting the presence of other fibrinolytic pathways. PAI levels (PAI activity, PAI-1 antigenicity, PAI-2 antigenicity) and vWF levels were significantly higher in patients with tuberculosis and empyema than in patients with cancer or cardiac failure. Regression analysis between inflammatory and fibrinolytic parameters showed that pleural PAI levels were significantly correlated with pleural neutrophil count, vWF levels, and plasma fibrinogen levels. D-D levels were correlated with blood ESR. No significant difference in pleural t-PA, u-PA and D-D levels was observed between aetiologies. The highest pleural t-PA and u-PA values were noted in patients with cancer, especially lymphoma. Plasma t-PA levels were higher in patients with pleural effusion secondary to congestive heart failure, but this difference did not reach statistical significance.In conclusion, pleural PAI levels are related to polymorphonuclear count and vWF levels, i.e. to inflammatory processes. Elevated levels of plasminogen activators suggest a possible role in some malignant pleural diseases.

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mentioning

confidence: 72%

Fibrinolytic and inflammatory processes in pleural effusions

Philip-Joët¹,

Alessi²,

Philip-Joet³

et al. 1995

Eur Respir J

Self Cite

103

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“…It is, however, a common finding that several coagulation and fibrinolytic factors cluster together and correlate possibly through a common regulatory mechanism. [20][21][22] Plasminogen levels were missing for 1 control subject. Q indicates quartile; and CRP, C-reactive protein.…”

Section: Discussionmentioning

confidence: 99%

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men

Meltzer

Doggen

Groot

et al. 2010

Blood

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Hypofibrinolysis as measured with overall clot lysis assays is associated with risk of arterial thrombosis. Individual components of the fibrinolytic system, however, have not been studied extensively in relation to arterial disease, or results of studies were inconsistent. The relation between plasminogen and ␣2-antiplasmin levels and cardiovascular risk factors and the association between plasminogen, ␣2-antiplasmin, tissue-plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) and risk of myocardial infarction was investigated in the Study of Myocardial Infarctions Leiden (555 men with a first myocardial infarction and 635 controls). ␣2-antiplasmin was associated with age and lipid levels, whereas plasminogen correlated with lipids, C-reactive protein, and smoking. Increased levels of all fibrinolytic factors were associated with myocardial infarction. Age-adjusted odds ratios (ORs; 95% confidence interval) for quartile 4 compared with 1 were 1.7 (1.2-2.3) for plasminogen, 1.9 (1.3-2.6) for ␣2-antiplasmin, 1.2-2.3) for t-PA, and 1.7 (1.2-2.4) (

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“…Although the mechanisms need to be elucidated some evidence suggests that hyperglycemia and hyperinsulinemia may lead to impaired fibrinolysis and thrombosis as shown by clinical (Calles-Escandon et al, 1998) and correlational studies (Juhan-Vague et al, 1989;Meigs et al, 2000), thereby increasing the risk of CHD (Gerstein & Yusuf, 1996;Ruige et al, 1998).…”

Section: The Glycemic Index In Coronary Heart Diseasementioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

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Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

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Plasma plasminogen activator inhibitor-1 in angina pectoris. Influence of plasma insulin and acute-phase response.

Cited by 207 publications

References 29 publications

Fibrinolytic and inflammatory processes in pleural effusions

Fibrinolytic and inflammatory processes in pleural effusions

Plasma levels of fibrinolytic proteins and the risk of myocardial infarction in men

Glycemic index in chronic disease: a review

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