Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition

Saadatian‐Elahi, Mitra; Slimani, Nadia; Chajès, Véronique; Jenab, Mazda; Goudable, J.; Biessy, Carine; Ferrari, Pietro; Byrnes, Graham; Autier, Philippe; Peeters, Petra H.M.; Ocké, Marga C.; Mesquita, Bas Bueno de; Johansson, Ingegerd; Hallmans, Göran; Manjer, Jonas; Wirfält, Elisabet; González, Carlos A.; Navarro, Carmen; Martínez, Carmen; Amiano, Pilar; Suárez, Laudina Rodríguez; Ardanaz, Eva; Tjønneland, Anne; Halkjær, Jytte; Overvad, Kim; Jakobsen, Marianne Uhre; Berrino, Franco; Pala, Valeria; Palli, Domenico; Tumino, Rosario; Víneis, Paolo; Magistris, Maria Santucci de; Spencer, Elizabeth A.; Crowe, Francesca L.; Bingham, Sheila; Khaw, Kay Tee; Linseisen, Jakob; Rohrmann, Sabine; Boeing, Heiner; Nöethlings, Ute; Olsen, Anja; Skeie, Guri; Lund, Eiliv; Trichopoulou, Antonia; Oustoglou, Erifili; Clavel-Chapelon, F.; Riboli, Elio

doi:10.3945/ajcn.2008.26834

Cited by 190 publications

(186 citation statements)

References 38 publications

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“…Evidence in earlier studies also suggests an inverse association of pentadecanoic acid 15:0 and margaric acid 17:0 with the risk of type 2 diabetes [15,28,32]. Odd chain fatty acids are found in milk fat and fish [33][34][35][36]. There was positive correlation between odd chain fatty acids with DHA (22:6n-3) in this study.…”

Section: Discussionsupporting

confidence: 65%

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

et al. 2015

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Aims/hypothesis Our aim was to investigate the fasting proportions of fatty acids and estimated desaturase and elongase activities in three different lipid fractions in plasma, phospholipids (PLs), cholesteryl esters (CEs) and triacylglycerols (TGs), as predictors for the worsening of glycaemia (area under the glucose curve in an OGTT [glucose AUC]) and incident type 2 diabetes in a 5.9 year follow-up of the Metabolic Syndrome in Men population-based cohort. Methods Fatty acid proportions were measured in plasma PL, CE and TG fractions in 1,364 Finnish men aged 45-68 years at baseline. The prospective follow-up study included only men who were non-diabetic at baseline and had data available at follow-up (n=1,302). A total of 71 participants developed new type 2 diabetes during follow-up.Results After adjusting for confounding factors, total saturated fatty acids, palmitoleic acid (16:1n-7), dihomo-γ-linolenic acid (20:3n-6) and estimated stearoyl-CoA desaturase 1 and Δ 6 -desaturase (D6D) enzyme activities significantly predicted the worsening of glycaemia whereas total polyunsaturated fatty acid, linoleic acid (18:2n-6) and elongase activity predicted a decrease in the glucose AUC. Estimated D6D activity and dihomo-γ-linolenic acid (20:3n-6) were associated with an increased risk of incident type 2 diabetes. Results were consistent across the three different lipid fractions. However, fatty acid proportions in the PL and CE fractions were stronger predictors for glycaemia and incident type 2 diabetes compared with fatty acid proportions in the TG fraction. Conclusions/interpretation Selected fatty acid proportions of plasma lipid fractions and their ratios, which reflect desaturase and elongase enzyme activities, may be good biomarkers for the worsening of glycaemia and incident type 2 diabetes.

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Section: Discussionsupporting

confidence: 65%

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

et al. 2015

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“…20 A previous study showed a positive correlation between cellular EPA and DHA with age, and a negative correlation with body mass index. 21 Levels may also differ with ethnicity, even among Asian populations.…”

Section: Discussionmentioning

confidence: 99%

Blood Eicosapentaenoic Acid and Docosahexaenoic Acid as Predictors of All-Cause Mortality in Patients With Acute Myocardial Infarction Data From Infarction Prognosis Study (IPS) Registry

Lee

Shin

Kim

et al. 2009

Circ J

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Background: Although ω-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases, their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results:The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males; mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29, P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients. (Circ J 2009; 73: 2250 -2257

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“…Many processed foods, including foods from major companies, still contain high levels of industrially produced trans-fatty acids, despite efforts to reduce them (Aro et al, 1998;McCarthy et al, 2008). A cross-sectional study on plasma fatty acid levels among a sub-sample of our study population (N ¼ 3003) shows a high correlation (r ¼ 0.72, Po0.01) between margarines and elaidic acid (trans 18:1 n-9), a specific biomarker of hardened fats and their related industrial foodstuffs (Saadatian-Elahi et al, 2009). Higher levels of plasma elaidic acid were observed in northern and central than in southern regions, which is compatible with the geographical differences in the consumption of highly processed foods reported in our analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Details on the rationale, structure and validity of EPIC-SOFT for between-population comparisons are reported elsewhere (Slimani et al, 2002bAl-Delaimy et al, 2005;Ferrari et al, 2009;Saadatian-Elahi et al, 2009).…”

Section: Dietary Variablesmentioning

confidence: 99%