Plasma Phospholipid Fatty Acid Content Is Related to Disease Activity in Ankylosing Spondylitis

Abstract

There was a positive correlation between levels of arachidonic acid in plasma phospholipids and disease activity assessed by BASDAI in patients with AS. A Western diet does not appear to influence this correlation, but seems to affect blood lipids involved in atherogenic processes.

Relationship between diet and ankylosing spondylitis: A systematic review

“…Description of the included studies and participants Multiple studies were conducted in Sweden and United Kingdom, and individual studies in Norway, Belgium, France, Australia, New Zealand, China, Portugal, and Turkey (Table 1, Appendix 1) and were published between 1991 and 2014 (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(37)(38)(39)(40). Seven of the included studies were case series; three were treatment outcome studies with all the participants receiving intervention, three were randomized clinical trials, one was a case-control study, and one study investigated the gene-environment interaction using a case-only design (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(37)(38)(39)(40).…”

“…After further consideration, 3 abstracts were removed because they did not include the necessary information and 46 full-text articles were removed because they did not report AS (n=3), did not look at relationship between AS and diet (n=2), included children (n=1), had a very small sample of AS patients (n=4), contained case reports (n=3), did not report information on diet (n=1), was in the Chinese language (n=1), did not report diet (n=25), did not report information on AS (n=2), and were non-systematic reviews (n=3) and thesis (duplicate publication, n=1). There were a total of 16 studies included in the review, 10 of which were full-text papers, two were letters, two studies were summarized in review articles, and two were conference abstracts (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40).…”

“…Seven of the included studies were case series; three were treatment outcome studies with all the participants receiving intervention, three were randomized clinical trials, one was a case-control study, and one study investigated the gene-environment interaction using a case-only design (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(37)(38)(39)(40). All of the studies were conducted in a hospital setting, except one study that recruited participants via a Web site (Table 1, Appendix 1) (28).…”

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

“…Moreover, according to the literature, dietary patterns with high fat and carbohydrates and low fiber, such as the "Western Diet", can lead to serious disbiosis 43,44 . In addition, Sundstrom B. et al indicated that the increased delta-5-desaturase (D5D) activity is associated with an enhanced biosynthesis of AA which resulted in the increased incorporation of plasma phospholipids that are rich in arachidonic acid and which are correlated with development of AS 46 .…”

“…There is evidence, supporting that lifestyle, especially diet and supplementation of vitamin D, has a significant role in disease progression and improving the well-being of these patients [12][13][14] . Furthermore, significant evidence indicates that nutritional factors, such as high starch consumption and other factors, such as the blood phospholipids that are rich in arachidonic acid, fatty acids abnormality, and low levels of vitamin D, are related to the development of AS and psoriatic arthritis [14][15][16][17] . The purpose of this review is primarily to investigate the relationship between diet and disease progression as well as to identify a nutritional care process based on clinical practice guidelines that could improve the well-being of people with AS.…”