Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men

Pereira‐Caro, Gema; Clifford, Michael N.; Polyviou, Thelma; Ludwig, Iziar A.; Alfheeaid, Hani A.; Moreno‐Rojas, José Manuel; García, Ada L.; Malkova, Dalia; Crozier, Alan

doi:10.1016/j.freeradbiomed.2020.09.007

Cited by 22 publications

(17 citation statements)

References 52 publications

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“…Previous studies suggested that the regular intake of orange juice (OJ) reduces inflammatory reactions and oxidative stress. OJ flavanones, mainly naringenin-7-rutinoside and hesperetin-7-O-rutinoside, are reported to have a wide range of beneficial attributes on human health such as the improvement of lipid profile [37,38]. Garlic belongs to the Allium genus and is traditionally used as a medicinal plant all over the world.…”

Section: Plant-derived Bioactive Componentsmentioning

confidence: 99%

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Samtiya

Aluko

Dhewa

et al. 2021

Foods

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Plant foods are consumed worldwide due to their immense energy density and nutritive value. Their consumption has been following an increasing trend due to several metabolic disorders linked to non-vegetarian diets. In addition to their nutritive value, plant foods contain several bioactive constituents that have been shown to possess health-promoting properties. Plant-derived bioactive compounds, such as biologically active proteins, polyphenols, phytosterols, biogenic amines, carotenoids, etc., have been reported to be beneficial for human health, for instance in cases of cancer, cardiovascular diseases, and diabetes, as well as for people with gut, immune function, and neurodegenerative disorders. Previous studies have reported that bioactive components possess antioxidative, anti-inflammatory, and immunomodulatory properties, in addition to improving intestinal barrier functioning etc., which contribute to their ability to mitigate the pathological impact of various human diseases. This review describes the bioactive components derived from fruit, vegetables, cereals, and other plant sources with health promoting attributes, and the mechanisms responsible for the bioactive properties of some of these plant components. This review mainly compiles the potential of food derived bioactive compounds, providing information for researchers that may be valuable for devising future strategies such as choosing promising bioactive ingredients to make functional foods for various non-communicable disorders.

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Section: Plant-derived Bioactive Componentsmentioning

confidence: 99%

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Samtiya

Aluko

Dhewa

et al. 2021

Foods

Self Cite

291

147

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show abstract

“…Feliciano et al, 2017;R. P. Feliciano, A. Boeres, et al, 2016;Henning et al, 2013;Keane et al, 2015;Koli et al, 2010;Lang et al, 2013;Li et al, 2000;Loke et al, 2009;Ludwig et al, 2015;McKay et al, 2015;Mueller et al, 2017;Ottaviani et al, 2016;Pereira-Caro et al, 2020;Pimpão et al, 2015;Prymont-Przyminska et al, 2016Rodriguez-Mateos et al, 2016Rodriguez-Mateos, Rendeiro, et al, 2013;Russell et al, 2009;Sandhu et al, 2018;Scherbl et al, 2016;Stalmach et al, 2012Stalmach et al, , 2009Stalmach et al, , 2014Suárez et al, 2009;Urpi-Sarda et al, 2009;van der Pijl et al, 2015;van Duynhoven et al, 2014;Vitaglione et al, 2007;Zhang & Zuo, 2004;Zhong et al, 2017).…”

Section: Intervention Studies Identifying and Quantifying The Lmw Phe...unclassified

“…We have searched PubMed for human intervention studies, which have identified and quantified LMW phenolic metabolites in human blood using diets rich in (poly)phenols or using flavonoid supplementation. In total, we have identified 42 intervention studies that employed either (i) dietary sources such as fruits or derivates thereof (e.g., juice, fruits, cake, coffee) in a single dose (Supplementary Table 2), (ii) dietary sources in multiple doses (Supplementary Table 3), or (iii) supplementation using plant extracts or pure flavonoids in capsules (Supplementary Table 4) (Azzini et al., 2010; Bresciani et al., 2017; Caccetta et al., 2000; Castello et al., 2018; Curtis et al., 2019; Czank et al., 2013; Rachel M. de Ferrars, Czank et al., 2014; R. M. de Ferrars, Cassidy et al., 2014; de la Torre et al., 2003; R. Feliciano et al., 2017; R. Feliciano, Istas, et al., 2016; R. P. Feliciano, A. Boeres, et al., 2016; Henning et al., 2013; Keane et al., 2015; Koli et al., 2010; Lang et al., 2013; Li et al., 2000; Loke et al., 2009; Ludwig et al., 2015; McKay et al., 2015; Mueller et al., 2017; Ottaviani et al., 2016; Pereira‐Caro et al., 2020; Pimpão et al., 2015; Prymont‐Przyminska et al., 2016, 2014; Rodriguez‐Mateos et al., 2016, 2014; Rodriguez‐Mateos, Rendeiro, et al., 2013; Russell et al., 2009; Sandhu et al., 2018; Scherbl et al., 2016; Stalmach et al., 2012, 2009, 2014; Suárez et al., 2009; Urpi‐Sarda et al., 2009; van der Pijl et al., 2015; van Duynhoven et al., 2014; Vitaglione et al., 2007; Zhang & Zuo, 2004; Zhong et al., 2017).…”

Section: Intervention Studies Identifying and Quantifying The Lmw Phe...mentioning

confidence: 99%

A look beyond dietary (poly)phenols: The low molecular weight phenolic metabolites and their concentrations in human circulation

Carregosa

Pinto

Ávila‐Gálvez

et al. 2022

Comp Rev Food Sci Food Safe

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A large number of epidemiological studies have shown that consumption of fruits, vegetables, and beverages rich in (poly)phenols promote numerous health benefits from cardiovascular to neurological diseases. Evidence on (poly)phenols has been applied mainly to flavonoids, yet the role of phenolic acids has been largely overlooked. Such phenolics present in food combine with those resulting from gut microbiota catabolism of flavonoids and chlorogenic acids and those produced by endogenous pathways, resulting in large concentrations of low molecular weight phenolic metabolites in human circulation. Independently of the origin, in human intervention studies using diets rich in (poly)phenols, a total of 137 low molecular weight phenolic metabolites have been detected and quantified in human circulation with largely unknown biological function. In this review, we will pinpoint two main aspects of the low molecular weight phenolic metabolites: (i) the microbiota responsible for their generation, and (ii) the analysis (quali‐ and quantitative) in human circulation and their respective pharmacokinetics. In doing so, we aim to drive scientific advances regarding the ubiquitous roles of low molecular weight phenolic metabolites using physiologically relevant concentrations and under (patho)physiologically relevant conditions in humans.

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“…Chlorogenic acids PII/MM Plasma/urine [32,33] Phenolic acids [34] PI [35] PII Plasma [36] MM [37] Green tea Flavan-3-ols PII Urine [38] PII/MM [39] Black tea Hydroxybenzoic acids [40] Flavonoids and phenolic acids Plasma/urine [41] Yerba mate Flavonols and phenolic acids [42] Orange juice Flavonoids and phenolic acids PII Plasma/urine [43] Flavanones and flavonols Urine [44] Flavanoids PII/MM [45] Flavanones [46] Plasma/urine [47] Red wine…”

Section: Coffeementioning

confidence: 99%

Metabolomics Technologies for the Identification and Quantification of Dietary Phenolic Compound Metabolites: An Overview

et al. 2021

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In the search for natural products with properties that may protect against or slow down chronic and degenerative diseases (e.g., cancer, and cardiovascular and neurodegenerative conditions), phenolic compounds (PC) with benefits for human health have been identified. The biological effects of PC in vivo depend on their bioavailability, intestinal absorption, metabolism, and interaction with target tissues. The identification of phenolic compounds metabolites (PCM), in biological samples, after food ingestion rich in PC is a first step to understand the overall effect on human health. However, their wide range of physicochemical properties, levels of abundance, and lack of reference standards, renders its identification and quantification a challenging task for existing analytical platforms. The most frequent approaches to metabolomics analysis combine mass spectrometry and NMR, parallel technologies that provide an overview of the metabolome and high-power compound elucidation. In this scenario, the aim of this review is to summarize the pre-analytical separation processes for plasma and urine samples and the technologies applied in quantitative and qualitative analysis of PCM. Additionally, a comparison of targeted and non-targeted approaches is presented, not available in previous reviews, which may be useful for future metabolomics studies of PCM.

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Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men

Abstract: A. (2020) Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men.

Cited by 22 publications

References 52 publications

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview

A look beyond dietary (poly)phenols: The low molecular weight phenolic metabolites and their concentrations in human circulation

Metabolomics Technologies for the Identification and Quantification of Dietary Phenolic Compound Metabolites: An Overview

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