Plasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia: a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group study

Abstract

TG concentrations that are cytotoxic to human leukemia cell lines can be achieved in plasma after a 60 mg/m2 oral dose of TG and in plasma and CSF during CIVI of TG.

Expanding Poliomyelitis and Measles Surveillance Networks to Establish Surveillance for Acute Meningitis and Encephalitis Syndromes—Bangladesh, China, and India, 2006-2008

“…9 Funding for surveillance often is disease-specific and time-limited, and can result in multiple, parallel surveillance systems that compete for resources, are not adequately funded, and are not sustainable. To compensate for the limitations of bacterial culture, where resources are available, rt-PCR can be used to enhance the sensitivity of laboratory-supported bacterial meningitis surveillance.…”

Suffocation Deaths Associated With Use of Infant Sleep Positioners—United States, 1997-2011

“…9 In 2011, AAP released a comprehensive policy statement on safe sleep environments for infants to reduce the risk for SIDS and suffocation. 9 In 2011, AAP released a comprehensive policy statement on safe sleep environments for infants to reduce the risk for SIDS and suffocation.…”

HIV Prevention Education and HIV-Related Policies in Secondary Schools—Selected Sites, United States, 2006

“…5 The finding that in approximately half of the states and school districts conducting surveys, less than 50% of secondary schools had a policy on students or staff members with HIV infection or AIDS is consistent with previously reported national data. 6 In addition, the median percentage of schools with such a policy has decreased since 1996. Reasons for these decreases warrant further investigation.…”