Plasma Parameter Aspects in the Fabrication of Stable Amine Functionalized Plasma Polymer Films

Daunton, C; Smith, Louise E.; Whittle, Jason D.; Short, Robert D.; Steele, David A.; Michelmore, Andrew

doi:10.1002/ppap.201400215

Cited by 25 publications

(23 citation statements)

References 57 publications

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“…EDA showed a significant increase in the silicon signal, particularly at high primary amine concentrations. This is consistent with previous measurements using the current reactor, although at a higher pressure, 25 which showed that EDA films were unstable except at high power. Indeed, from the data it is likely that the EDA films at low power were almost completely dissolved.…”

Section: Stabilitysupporting

confidence: 93%

Chemical and physical processes in the retention of functional groups in plasma polymers studied by plasma phase mass spectroscopy

Ryssy

Prioste-Amaral

Assuncao

et al. 2016

Phys. Chem. Chem. Phys.

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Surface engineering of functionalised polymer films is a rapidly expanding field of research with cross disciplinary implications and numerous applications. One method of generating functionalised polymer films is radio frequency induced plasma polymerisation which provides a substrate independent coating. However, there is currently limited understanding surrounding chemical interactions in the plasma phase and physical interactions at the plasma-surface interface, and their effect on functional group retention in the thin film. Here we investigate functionalised plasma polymer films generated from four precursors containing primary amines. Using XPS and fluorine tagging with 4-(trifluoromethyl)benzaldehyde, the primary amine content of plasma polymer films was measured as a function of applied power at constant precursor pressure. The results were then correlated with analysis of the plasma phase by mass spectrometry which showed loss of amine functionality for both neutral and ionic species. Surface interactions are also shown to decrease primary amine retention due to abstraction of hydrogen by high energy ion impacts. The stability of the plasma polymers in aqueous solution was also assessed and is shown to be precursor dependent. Increased understanding of the chemical and physical processes in the plasma phase and at the surface are therefore critical in designing improved plasma polymerisation processes.

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Section: Stabilitysupporting

confidence: 93%

Chemical and physical processes in the retention of functional groups in plasma polymers studied by plasma phase mass spectroscopy

Ryssy

Prioste-Amaral

Assuncao

et al. 2016

Phys. Chem. Chem. Phys.

Self Cite

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“…The plasma processing of materials including the amine plasma polymerization has gained considerable popularity for the development of bioactive materials, biosensors, antibacterial, and anti‐fungal surfaces . Various processes, monomers, and plasma reactors were employed to obtain the desired properties of the layers and several reviews reported the most prominent results achieved using allylamine, heptylamine, ethylenediamine, NH 3 , NH 3 /C 2 H 4 , and NH 3 /C 2 H 2 plasma polymerizations. However, several drawbacks were noticed for these methods as well.…”

Section: Introductionmentioning

confidence: 99%

Cyclopropylamine plasma polymers for increased cell adhesion and growth

Manakhov

Landová

Medalová

et al. 2016

Plasma Processes & Polymers

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Plasma polymers with NHx groups were deposited from cyclopropylamine in low pressure radio frequency (RF) discharges. The amount of NHx decreased with increasing average power Pav, whereas the layer dissolution in water decreased and high Pav led to a slight film swelling. The C2C12 cells demonstrated very high adhesion to the layers regardless of the deposition conditions. Although the surface chemistry of amine‐rich layers should enhance the cell proliferation, the WST‐1 assay, and immunocytochemistry revealed lower cell proliferation and viability on the layers exhibiting above 18% of relative thickness loss in water. Promising results were obtained on the layers with better water stability and bearing 7–10% of NHx.

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“…The plasma coating also has to maintain its mechanical integrity since premature delamination or cracking will lessen its benefit. Stability of plasma coatings for biomedical applications has been widely studied through immersing specimens in water or phosphate buffered saline for a certain period of time [36–39]. In this paper, we report on the chemical stability of plasma nanocoatings after prolonged immersion in a simulated body fluid (SBF) at 37 °C.…”

Section: Introductionmentioning

confidence: 99%

A chemical stability study of trimethylsilane plasma nanocoatings for coronary stents

Jones

Chen

2016

Journal of Biomaterials Science, Polymer Edition

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In this study, trimethylsilane (TMS) plasma nanocoatings were deposited onto 316L stainless steel coupons in direct current (DC) and radio frequency (RF) glow discharges and additional NH3/O2 plasma treatment to tailor the coating surface properties. The chemical stability of the plasma nanocoatings were evaluated after 12 week (~3 month) storage under dry condition (25 °C) and immersion in simulated body fluid (SBF) at 37 °C. It was found that nanocoatings did not impact surface roughness of underlying stainless steel substrates. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) were used to characterize surface chemistry and compositions. Both DC and RF TMS plasma nanocoatings had Si– and C– rich composition; and the O– and N– contents on the surfaces were substantially increased after NH3/O2 plasma treatment. Contact angle measurements showed that DC TMS nanocoating with NH3/O2 treatment generated very hydrophilic surfaces. DC TMS nanocoatings with NH3/O2 treatment showed minimal surface chemistry change after 12 week immersion in SBF. However, nitrogen functionalities on RF-TMS coating with NH3/O2 post treatment were not as stable as in DC case. Cell culture studies revealed that the surfaces with DC coating and NH3/O2 post treatment demonstrated substantially improved proliferation of endothelial cells over the 12 week storage period at both dry and wet conditions, as compared to other coated surfaces. Therefore, DC nanocoatings with NH3/O2 post treatment may be chemically stable for long-term properties, including shelf-life storage and exposure to the bloodstream for coronary stent applications.

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Plasma Parameter Aspects in the Fabrication of Stable Amine Functionalized Plasma Polymer Films

Cited by 25 publications

References 57 publications

Chemical and physical processes in the retention of functional groups in plasma polymers studied by plasma phase mass spectroscopy

Chemical and physical processes in the retention of functional groups in plasma polymers studied by plasma phase mass spectroscopy

Cyclopropylamine plasma polymers for increased cell adhesion and growth

A chemical stability study of trimethylsilane plasma nanocoatings for coronary stents

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