Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia

Puertas, Maria C.; Martínez-Martos, José Manuel; Cobo, Manuela; Carrera, Marı́a Pilar; Mayas, Marı́a Dolores; Ramírez-Expósito, María Jesús

doi:10.1016/j.exger.2012.05.019

Cited by 116 publications

(73 citation statements)

References 30 publications

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“…The decrease in the extracellular catalase activity (which is one of the 5 different CAT isoforms) observed only in AD subjects would be consistent with an impairment in these patients in the removal of H 2 O 2 that in turn could lead to a microenvironmental redox state perturbation. Our results are consistent with those previously reported by Puertas et al [42], who also observed a significant decreased CAT activity in AD subjects, although in that study was also reported a decreased GPx activity. On the other hand, other studies showed either an increase or no changes of CAT and GPx activity in AD [6,[47][48][49], indicating the existence of controversy on this point.…”

Section: Discussionsupporting

confidence: 94%

“…2). These data are in good agreement with those reported by Padurariu et al [41], although other authors did not find differences in the SOD activity in plasma from AD patients [19,42]. Interestingly, the female control group had a lower SOD3 activity than men, that further decreased with the age ( CHS W > 75 years vs. CHS W ≤75 years); while no differences in term of gender and age where found in the AD and MCI groups.…”

Section: Discussionsupporting

confidence: 92%

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Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients

Arce-Varas¹,

Abate²,

Prandelli³

et al. 2016

CAR

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Abstract:Background: Many studies suggest oxidative stress as an early feature of Alzheimer's Disease (AD). However, evidence of established oxidative stress in AD peripheral cells is still inconclusive, possibly due to both, differences in the type of samples and the heterogeneity of oxidative markers used in different studies.Objective: The aim of this study was to evaluate blood-based redox alterations in Alzheimer's Disease in order to identify a peculiar disease profile. Method:To that purpose, we measured the activity of Superoxide Dismutase, Catalase and Glutathione Peroxidase both in the extracellular and the intracellular blood compartments of AD, MCI and control subjects. The amount of an open isoform of p53 protein (unfolded p53), resulting from oxidative modifications was also determined.Results: Decreased SOD, increased GPx activity and higher p53 open isoform were found in both AD and MCI plasma compared to controls. In blood peripheral mononuclear cells, SOD activity was also decreased in both AD and MCI, and unfolded p53 increased exquisitely in younger AD males compared to controls. Conclusion:Overall, these data highlight the importance of considering both extracellular and intracellular compartments, in the determination of antioxidant enzyme activities as well as specific oxidation end-products, in order to identify peculiar blood-based redox alterations in AD pathology.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients

Arce-Varas¹,

Abate²,

Prandelli³

et al. 2016

CAR

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show abstract

“…Moreover, the ease of blood extraction and analysis further increases the value of blood-based biomarkers. Studies have reported decrease in blood plasma levels of GSH in AD as well as MCI subjects [55][56][57][58]. A study that assessed alterations in various OS-related biomarkers for AD alongside other neurodegenerative disorders showed that in AD patients both total GSH as well as the GSH/GSSG ratio in plasma decreased in relation to AD progression [57].…”

Section: Detection Of Gsh In Bloodmentioning

confidence: 97%

The Emerging Role of Glutathione in Alzheimer's Disease

Saharan

Mandal

2014

JAD

147

100

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With millions of older individuals presently suffering from Alzheimer's disease (AD) worldwide, AD is an unduly common form of dementia that exacts a heavy toll on affected individuals and their families. One of the emerging causative factors associated with AD pathology is oxidative stress. This AD-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (GSH). In this article, we review the role of GSH in AD from a pathological as well as a diagnostic point of view. We recapitulate the literature that has assessed the role of GSH in AD onset and progression. We discuss the various methodologies through which alterations in GSH levels might be monitored, and highlight the yet uncharted potential of assaying GSH levels in vivo with magnetic resonance spectroscopy in AD therapeutics and prognostics. Finally, the present manuscript integrates findings from various studies to elucidate the possible molecular mechanisms through which disruptions in GSH homeostasis may contribute to AD pathology.

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“…37,38 It was the same for several investigations on glutathione peroxidase or reductase and catalase activity in AD. 37,39,40 In contrast, data on the analysis of total antioxidant defense were more univocal through the literature. The TAS assay usually works as an indirect measure of the resistance of serum to be oxidized by an oxidant (see Materials and Methods).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Status andAPOEGenotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia

Zito¹,

Polimanti

Panetta

et al. 2013

Rejuvenation Research

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Different factors interact to develop neurodegeneration in patients with dementia and other neurodegenerative disorders. Oxidative stress and the e4 allele of apolipoprotein E (ApoE) are associated with significant alteration in lipid metabolism, in turn connected to a variety of neurodegenerative diseases and aging. Thus, a better understanding of the pathogenetic pathways associated with lipid dyshomeostasis may elucidate the causes of neurodegenerative processes. To address this issue, we evaluated the effects of antioxidant status and APOE genotype on neurodegeneration in patients with dementia of the Alzheimer type (AD), with vascular dementia (VaD), and in elderly healthy controls. Eighty-two AD, 42 VaD patients, and 26 healthy controls were recruited and underwent medial temporal lobe atrophy (MTA) assessment, white matter hyperintensities rating (WMH), serum total antioxidant status assaying (TAS), and APOE genotyping. A logistic regression algorithm applied to our data revealed that a 0.01 mmol/L decrease of TAS concentration increased the probability of MTA by 24% ( p = 0.038) and that carriers of the APOE e4 allele showed higher WMH scores ( p = 0.018), confirming that small variations in antioxidant systems homeostasis are associated with relevant modifications of disease risk. Furthermore, in individuals with analogous TAS values, the presence of the e4 allele increased the predicted probability of having MTA. These outcomes further sustain the interaction of oxidative stress and APOE genotype to neurodegeneration.

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Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia

Cited by 116 publications

References 30 publications

Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients

Comparison of Extracellular and Intracellular Blood Compartments Highlights Redox Alterations in Alzheimer's and Mild Cognitive Impairment Patients

The Emerging Role of Glutathione in Alzheimer's Disease

Antioxidant Status andAPOEGenotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia

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