Plasma oxidative stress level of IgA nephropathy in children and the effect of early intervention with angiotensin-converting enzyme inhibitors

Pei, Yuxin; Xu, Yong; Ruan, Jingwei; Rong, Liping; Jiang, Mengjie; Ying, Ming; Jiang, Xiaoyun

doi:10.1177/1470320316647240

Cited by 10 publications

(10 citation statements)

References 17 publications

(17 reference statements)

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“…By using the MDA analysis and/or the TBA test, also making a sample measurements interpretation, we may determine the OS within an organism (Trevisan et al 2001 ). For instance, MDA measurements were carried out in a study that included a group of 38 children diagnosed with IgA nephropathy in order to assess whether the serum OS biomarkers levels measurements can be potentially used as a non-invasive diagnostic method in this disease (Pei et al 2016 ). It was reported that the increased plasma level of advanced oxidation protein products and MDA were detected, and the SOD serum levels were decreased (Pei et al 2016 ).…”

Section: Biomarkers Of Osmentioning

confidence: 99%

“…For instance, MDA measurements were carried out in a study that included a group of 38 children diagnosed with IgA nephropathy in order to assess whether the serum OS biomarkers levels measurements can be potentially used as a non-invasive diagnostic method in this disease (Pei et al 2016 ). It was reported that the increased plasma level of advanced oxidation protein products and MDA were detected, and the SOD serum levels were decreased (Pei et al 2016 ). Interestingly, it has been reported that serum MDA can be downregulated by a recently synthesized caffeic acid derivative: N -propyl caffeamide (Cheng et al 2017 ), which belongs to a class of potent candidates for anti-inflammatory and cardioprotective drugs.…”

Section: Biomarkers Of Osmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Krata

Zagożdżon

Foroncewicz

et al. 2017

Arch. Immunol. Ther. Exp.

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Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism’s cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal disease. The course of CKD depends on the primary disease. It is assumed that one of the factors influencing the course of CKD might be OS. In the current work, we review whether monitoring the OS-associated biomarkers in nephrology patients can support the decision-making process regarding diagnosis, prognostication and treatment initiation.

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Section: Biomarkers Of Osmentioning

confidence: 99%

Section: Biomarkers Of Osmentioning

confidence: 99%

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Krata

Zagożdżon

Foroncewicz

et al. 2017

Arch. Immunol. Ther. Exp.

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“…Previous studies have shown that oxidative stress plays an important role in the pathophysiology of IgAN [ 13 – 17 ]. Advanced oxidation protein products (AOPPs), markers of oxidative stress, were higher in the serum of patients with IgAN than those of healthy controls, and levels of AOPPs were correlated with the rate of decline in renal function [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association between serum albumin level and incidence of end-stage renal disease in patients with Immunoglobulin A nephropathy: A possible role of albumin as an antioxidant agent

et al. 2018

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Serum albumin is the major intravascular antioxidant. Though oxidative stress plays an important role in the pathophysiology of Immunoglobulin A nephropathy (IgAN), the association between serum albumin and the progression of IgAN is not entirely understood. This retrospective cohort study of 1,352 participants with biopsy-proven IgAN determined the associations between serum albumin level and the incidence of end-stage renal disease (ESRD) using a Cox proportional hazards model. Patients were divided into three groups by tertiles of serum albumin level: Low, Middle, and High group (≤3.9 g/dL, 4.0–4.3 g/dL, ≥4.4 g/dL, respectively). During the median 5.1-year follow-up period, 152 patients (11.2%) developed ESRD. Participants in the Low group had a 1.88-fold increased risk for ESRD compared with those in the High group after adjustment for clinical parameters, including urinary protein excretion, and pathological parameters (Oxford classification). We also experimentally proved the antioxidant capacity of albumin on mesangial cells. The intracellular reactive oxygen species and mitochondrial injury, induced by hydrogen peroxide were significantly attenuated in albumin-pretreated mouse mesangial cells and human kidney cells compared with γ-globulin-pretreated cells. Low serum albumin level is an independent risk factor for ESRD in patients with IgAN. The mechanism could be explained by the antioxidant capacity of serum albumin.

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“…PUFAs play protective effects on renal function ( Taccone-Gallucci et al, 2006 ; Lauretani et al, 2008 ; Eide et al, 2016 ; Malhotra et al, 2016 ) and are highly susceptible to oxidative damage ( Yang et al, 2016 ). Intrarenal reactive oxygen species (ROS) that increase oxidative stress play a pivotal role in the development of IgAN ( Pei et al, 2016 ). Enhanced oxidative stress levels in the plasma and kidneys in IgAN patients could be the cause of the decreased plasma level of PUFAs ( Kobori et al, 2007 ; Pei et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…Intrarenal reactive oxygen species (ROS) that increase oxidative stress play a pivotal role in the development of IgAN ( Pei et al, 2016 ). Enhanced oxidative stress levels in the plasma and kidneys in IgAN patients could be the cause of the decreased plasma level of PUFAs ( Kobori et al, 2007 ; Pei et al, 2016 ). Recent studies suggested that increasing intake of PUFAs, such as DHA and eicosapentaenoic acid (EPA), significantly decreased plasma lipid hydroperoxide, a consequence of ROS overproduction ( Hassler et al, 2014 ) and is effective in the treatment of human IgAN ( Lee et al., 2013 ; Hirahashi, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients

Deng

Chen

et al. 2021

Journal of Molecular Cell Biology

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IgA nephropathy (IgAN) is a leading cause of chronic kidney disease (CKD), which are commonly accompanied by dyslipidemia. Obesity is also associated with dyslipidemia and risk of CKD, but the relation of the dyslipidemia patterns with obesity and disease progression in IgAN patients remains unknown. Traditional Chinese medicine (TCM) and the combined treatment with corticosteroids and TCM have been shown to be of benefit for IgAN patients, but predictive markers for guiding these treatments are lacking. Here, we quantified 545 lipid species in the plasma from 196 participants, including 140 IgAN patients and 56 healthy volunteers, and revealed an altered plasma lipidome in IgAN patients as compared to healthy participants. Association analysis showed that a sub-group of glycerides, particularly triacylglycerols (TGs) containing docosahexaenoic acid, were positively associated with high body mass index (BMI) in under- or normal weight IgAN patients, while several free fatty acids and sphingomyelins were positively associated with high BMI in overweight or obese IgAN patients. Further, our study suggested that elevated levels of eight lipids, mainly TG species containing linolenic acid, were independent risk factors for IgAN progression and also reported the prospective association of circulating lipids with treatment outcomes in IgAN. Taken together, our findings may not only help to achieve precision medicine but also provide a knowledge base for dietary intervention in the treatment of IgAN.

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Plasma oxidative stress level of IgA nephropathy in children and the effect of early intervention with angiotensin-converting enzyme inhibitors

Cited by 10 publications

References 17 publications

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Association between serum albumin level and incidence of end-stage renal disease in patients with Immunoglobulin A nephropathy: A possible role of albumin as an antioxidant agent

Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients

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