Plasma osteoprotegerin level is associated with hemorrhagic transformation in stroke patients who underwent endovascular thrombectomy

Kim, Hyung Jun; Park, Moo‐Seok; Joo, Ahran; Kang, Seung-Ji; Eum, Seuhyun; Song, Tae‐Jin

doi:10.1016/j.clineuro.2022.107305

Cited by 2 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, elevated levels of OPG have been found to be associated with incident [10,11,28], severity at admission [10,27,28], poor functional outcome [9,13,14] and mortality [9,15,16] following an IS event. This association is supported by evidence linking elevated plasma OPG levels to vulnerable carotid plaques [29], larger infarctions [13], higher National Institutes of Health Stroke Scale scores at admission [13] and the occurrence and severity of hemorrhagic transformation [30]. The potential mechanisms by which OPG may be linked to the development of inflammatory diseases such as atherosclerosis are multifaceted.…”

Section: Plos Onementioning

confidence: 89%

Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis

Pang,

Lin,

Wei

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Osteoprotegerin (OPG) is supposed to participate in the development of atherosclerosis and cardio-cerebrovascular disease. However, the results of research on relationship between OPG and ischemic stroke (IS) are controversial. Therefore, we carried out the first systematic review and meta-analysis to evaluate prognostic effect of osteoprotegerin in patients with IS. Methods We comprehensively searched databases of PubMed, Embase, and the Cochrane Library through 21 August 2023 to identify observational studies that evaluated effect of OPG on poor functional outcome (modified Rankin Scale [mRS] Score of 3–6) and mortality in patients with IS. Adjusted odds ratios (aOR) with a 95% confidence interval (CI) of each included study were used as much as possible to assess the pooled effect. Results Five studies that enrolled 4,506 patients in total fulfilled our inclusion criteria. Three studies were included in the pooled analysis for each endpoint since one of the included studies had provided data on poor functional outcome as well as mortality. OPG was neither associated with poor functional outcome (aOR 1.29, 95% CI 0.90–1.85) nor with mortality (aOR 1.57, 95% CI 0.90–2.74) in patients with IS. Conclusions There is insufficient evidence to demonstrate the correlation between OPG and mortality or poor functional outcome in IS patients. OPG cannot be applied to predict worse neurological function in IS patients based on the current evidence.

show abstract

Section: Plos Onementioning

confidence: 89%

Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis

Pang,

Lin,

Wei

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…The pathway of RANK (receptor activator of nuclear factor kappa B) – RANKL (RANK ligand) – OPG (osteoprotegerin) is recognized for its function in bone remodeling, where RANKL/RANK signaling controls the formation, activation, and survival of osteoclasts during regular bone modeling and remodeling. OPG inhibits osteoclast activation through the RANK receptor by binding to RANKL and increases bone volume and density ( 31 , 32 ). Oral inflammation produces pro-inflammatory cytokines, which are osteoclastogenic bone resorption-inducing cytokines.…”

Section: Discussionmentioning

confidence: 99%

Better oral hygiene is associated with a reduced risk of osteoporotic fracture: a nationwide cohort study

Park,

Kim

et al. 2023

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

BackgroundThe aim of this study was to examine the longitudinal association between oral health parameters and osteoporotic fracture.MethodsThe study included participants who received oral health screening by dentists from the National Health Screening cohort database of Korea between 2003 and 2006. The primary outcome was osteoporotic fracture occurrence, which was defined using specific international classification of diseases-10 codes; vertebral fracture (S22.0, S22.1, S32.0, S32.7, T08, M48.4, M48.5, and M49.5), hip fracture (S72.0 and S72.1), distal radius fracture (S52.5 and S52.6), and humerus fracture (S42.2 and S42.3). The presence of periodontitis and various oral health examination findings, such as missing teeth, caries, frequency of tooth brushing, and dental scaling, were analyzed using a Cox proportional hazard model to assess their association with osteoporotic fracture occurrence.ResultsThe analysis included a total of 194,192 participants, among whom 16,683 (8.59%) developed osteoporotic fracture during a median follow-up of 10.3 years. Poor oral health status, including periodontitis (adjusted hazard ratio [aHR]: 1.09, 95% confidence interval [CI]: 1.01–1.18, p = 0.039), a higher number of missing teeth (≥15; aHR: 1.59, 95% CI: 1.45–1.75, p < 0.001), and dental caries (≥6; aHR: 1.17, 95% CI: 1.02–1.35, p = 0.030), was associated with an increased risk of osteoporotic fracture. On the other hand, better oral hygiene behaviors such as brushing teeth frequently (≥3 times per day; aHR: 0.82, 95% CI: 0.78–0.86, p < 0.001) and having dental scaling within 1 year (aHR: 0.87, 95% CI: 0.84–0.90, p < 0.001) were negatively associated with the occurrence of osteoporotic fracture.ConclusionThe study found that poor oral health, such as periodontitis, missing teeth, and dental caries, was associated with an increased risk of osteoporotic fracture. Conversely, good oral hygiene behaviors like frequent teeth brushing and dental scaling within 1 year were associated with a reduced risk. Further research is needed to confirm this association.

show abstract

Plasma osteoprotegerin level is associated with hemorrhagic transformation in stroke patients who underwent endovascular thrombectomy

Cited by 2 publications

References 55 publications

Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis

Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis

Better oral hygiene is associated with a reduced risk of osteoporotic fracture: a nationwide cohort study

Contact Info

Product

Resources

About