Plasma Osteoprotegerin Level, a New Biochemical Marker of Atherosclerosis, is Associated with Diabetes Mellitus and Age in Coronary Artery Disease

박철수,; Youn, Ho-Joong; 최윤석,; 이동현,; Kim, Ji Hun; 오용석,; 백상홍,; 정욱성,; 김재형,; 최규보,; 홍순조,

doi:10.4070/kcj.2006.36.7.543

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…7) These findings suggest that OPG may play a potential role in the process of atherogenesis and atherosclerotic calcification. Recent studies have reported that an increased serum OPG level was significantly associated with the presence and the severity of coronary artery disease, [8][9][10] and also with the cardiovascular mortality of elderly women. 11) A recent prospective study reported that elevated OPG levels were an independent risk factor for cardiovascular disease in the general population.…”

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confidence: 99%

The Association of Osteoprotegerin with Cardiovascular Disease and the New York Heart Association Classification

et al. 2007

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Background and Objectives：Recent studies have suggested that there is a significant correlation between elevated serum Osteoprotegerin (OPG) levels and cardiovascular diseases. We investigated whether the serum OPG levels were associated with heart failure (HF), acute myocardial infarction (AMI) and unstable angina (UA), and whether the serum OPG levels were correlated with the NYHA classifications. Subjects and Methods：The serum OPG levels were measured in 127 patients suffering with HF, AMI and UA and they were hospitalized in the cardiology department, and these values were compared to 63 healthy controls. The NYHA classification was used to define the clinical disease severity. The serum OPG level was measured by performing ELISA. Results：The serum OPG levels were significantly higher in the patients with HF and AMI than those in the control subjects (p=0.003, p=0.002, respectively). The mean OPG levels were 555, 683, 774 and 856 pg/mL for the subjects and controls, according to the NYHA classifications II, III and IV, respectively. Multiple regression analysis revealed that the serum OPG levels were significantly associated with HF and AMI, and when all subjects were regrouped according to NYHA classification, the serum OPG levels were also significantly associated with the NYHA classification. Conclusion：The serum OPG levels were increased in Asian patients suffering with cardiovascular disease such as HF and AMI, and they were also increased with the NYHA classification. The serum OPG level could be a marker for different stages of cardiovascular disease. (Korean Circulation J 2007;37: [353][354][355][356][357][358]

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Section: Introductionmentioning

confidence: 99%

The Association of Osteoprotegerin with Cardiovascular Disease and the New York Heart Association Classification

et al. 2007

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“…The high level of serum OPG reported by many studies can be considered as the incomplete feedback action according to arteriosclerosis progression. 20 In other words, as it is well recognized that arteriosclerosis is a chronic inflammatory process, OPG has been suggested to act as the complementary protective system of blood vessels. OPG is upregulated in any condition that excessively activates arteriosclerosis and inflammatory pathways posing a risk to blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Serum Osteoprotegerin Is Associated With Calcified Carotid Plaque

Kwon

Choi

et al. 2016

Medicine

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Osteoprotegerin (OPG) is a kind of tumor necrosis factor, which is related to bone metabolism and vascular calcification. The increase of Osteoprotegerin concentration in serum is related to cardiovascular diseases in humans. The purpose of this study was to figure out the relevance between osteoprotegerin in serum and carotid calcification.Serum OPG concentrations were compared in 145 patients who underwent carotid sonography (average age: 68 ± 9 years old, male: female = 81:64). A calcified plaque (CP) (37 people [27%]), a noncalcified plaque (NCP) (54 people [37%]), and a nonplaque (NP) (54 people [37%]) were classified for this study.No significant differences among 3 groups were demonstrated in the distribution of age, diabetes, high blood pressure, and hyperlipidemia. Serum osteoprotegerin concentrations were significantly increased in CP group rather than NCP group or NP group; (median [interquartile range], 4016 [1410] vs 3210 [1802] pg/mL, P < 0.05 and 4016 [1410] vs 3204 [1754] pg/mL, P < 0.05). Serum osteoprotegerin concentrations did not indicate a significant difference between NCP Group or NP Group.This study had proved that patient group accompanied with carotid calcification in carotid artery disease had an increased serum OPG concentration, so it could consider that OPG plays an important function on calcification related to arteriosclerosis.

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Plasma Osteoprotegerin Level, a New Biochemical Marker of Atherosclerosis, is Associated with Diabetes Mellitus and Age in Coronary Artery Disease

Cited by 2 publications

References 26 publications

The Association of Osteoprotegerin with Cardiovascular Disease and the New York Heart Association Classification

The Association of Osteoprotegerin with Cardiovascular Disease and the New York Heart Association Classification

Serum Osteoprotegerin Is Associated With Calcified Carotid Plaque

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