Plasma osteopontin levels in patients with acute kidney injury requiring dialysis: a study in a tertiary care institute in South India

Varalakshmi, Boreddy; Kiranmyai, V. S.; Aparna, Bitla; Ram, R; Rao, P V L N Srinivas; Kumar, V Siva

doi:10.1007/s11255-020-02417-x

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…It is well established that OPN also functions as a protection factor in kidneys and guards tubular epithelial cells against apoptosis, similar to preliminary research on the role of OPN in AKI. Since the anti-apoptotic signals are no longer necessary once tubular epithelial cells have recovered from the injury, the tubular expression of OPN declines, leading to lower levels of OPN in the blood [ 100 ]. Immunoglobulin A nephropathy develops in part due to OPN (IgAN).…”

Section: Emerging Novel Biomarkers For Detecting Acute Kidney Injurymentioning

confidence: 99%

Proficient Novel Biomarkers Guide Early Detection of Acute Kidney Injury: A Review

2022

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The definition of acute kidney injury (AKI), despite improvements in criteria, continues to be based on the level of serum creatinine and urinary output that do not specifically indicate tubular function or injury, or glomerular function or injury that is not significant enough to warrant acute hospitalization of the patient. Finding novel biomarkers of AKI has become a major focus nowadays in nephrology to overcome the further complications of end stage renal disease (ESRD). Many compounds, such as KIM 1, IL 18, NGAL, uromodulin, calprotectin, vanin 1, galactin 3, platelet-derived growth factor (PDGF), urinary Na+/H+ exchanger isoform 3 (NHE3), retinol binding protein (RBP) and Cystatin C, are released from the renal tubules and thus any alterations in tubular function can be detected by measuring these parameters in urine. Additionally, glomerular injury can be detected by measuring immunoglobulin G, nephrin, podocalyxin, podocin, transferrin, netrin-1, pyruvate kinase M2, etc. in urine. These novel biomarkers will be useful for timing the initial insult and assessing the duration of AKI. According to available research, these biomarkers could be applied to assess the onset of AKI, distinguishing between kidney injury and dysfunction, directing the management of AKI, and enhancing disease diagnosis. Therefore, we intend to present recent developments in our understanding of significant biomarkers implicated in various aspects of renal damage. Numerous biomarkers are implicated in various pathophysiological processes that follow renal injury, and can improve prognosis and risk classification.

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Section: Emerging Novel Biomarkers For Detecting Acute Kidney Injurymentioning

confidence: 99%

Proficient Novel Biomarkers Guide Early Detection of Acute Kidney Injury: A Review

2022

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“…The role of OPN in the human kidney remains unclear; however, some studies indicate its potential influence on the embryonic kidney formation processes [140]. Recent studies suggest that OPN can be useful in AKI diagnosis and prognosis estimation [131,[141][142][143]. According to acute kidney dysfunction among cirrhotic patients, levels of urinary OPN vary depending on the AKI subtypes [131].…”

Section: Other Atn Biomarkersmentioning

confidence: 99%

Hepatorenal Syndrome—Novel Insights into Diagnostics and Treatment

Badura,

Frąk,

Hajdys

et al. 2023

IJMS

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Hepatorenal syndrome (HRS) is a disorder associated with cirrhosis and renal impairment, with portal hypertension as its major underlying cause. Moreover, HRS is the third most common cause of acute kidney injury, thus creating a major public health concern. This review summarizes the available information on the pathophysiological implications of HRS. We discuss pathogenesis associated with HRS. Mechanisms such as dysfunction of the circulatory system, bacterial infection, inflammation, impaired renal autoregulation, circulatory, and others, which have been identified as critical pathways for development of HRS, have become easier to diagnose in recent years. Additionally, relatively recently, renal dysfunction biomarkers have been found indicating renal injury, which are involved in the pathophysiology of HRS. This review also summarizes the available information on the management of HRS, focusing on vasoconstrictive drugs, renal replacement therapy, and liver transplant together with currently being investigated novel therapies. Analyzing new discoveries for the underlying causes of this condition assists the general research to improve understanding of the mechanism of pathophysiology and thus prevention of HRS.

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“…Askenazi et al [ 172 ] showed that urinary OPN is also a promising biomarker for detecting AKI in neonates, similar to NGAL and KIM-1. Varalakshmi et al [ 173 ] showed that plasma osteopontin can correlate with disease severity in a group of 35 AKI patients with renal replacement therapy.…”

Section: Biomarkers Of Allogeneic Kidney Transplant Rejectionmentioning

confidence: 99%

The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

Rogulska

Wojciechowska‐Koszko

Dołęgowska

et al. 2022

Journal of Immunology Research

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Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has become standard clinical practice, and it has a significant impact on reducing mortality and improving the quality of life of patients. Allogenic transplantation induces an immune response, which may lead to the rejection of the transplanted organ. The gold standard for evaluating rejection of the transplanted kidney by the recipient’s organism is a biopsy of this organ. However, due to the high invasiveness of this procedure, alternative diagnostic methods are being sought. Therefore, the biomarkers may play an essential predictive role in transplant rejection. A review of the most promising biomarkers for early diagnosis and prognosis prediction of allogenic kidney transplant rejection summarizes novel data on neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), C-X-C motif chemokine 10 (CXCL-10), cystatin C (CysC), osteopontin (OPN), and clusterin (CLU) and analyses the dynamics of changes of the biomarkers mentioned above in kidney diseases and the mechanism of rejection of the transplanted kidney.

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Plasma osteopontin levels in patients with acute kidney injury requiring dialysis: a study in a tertiary care institute in South India

Cited by 9 publications

References 17 publications

Proficient Novel Biomarkers Guide Early Detection of Acute Kidney Injury: A Review

Proficient Novel Biomarkers Guide Early Detection of Acute Kidney Injury: A Review

Hepatorenal Syndrome—Novel Insights into Diagnostics and Treatment

The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection

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