Plasma omega-3 fatty acids and incident diabetes in older adults

Djoussé, Luc; Biggs, Mary L.; Lemaître, Rozenn N.; King, Irena B.; Song, Xiaoling; Ix, Joachim H.; Mukamal, Kenneth J.; Siscovick, David S.; Mozaffarian, Dariush

doi:10.3945/ajcn.111.013334

Cited by 108 publications

(105 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Virtanen et al [12] observed that serum n-3 PUFA concentration was associated with a long-term lower risk of type 2 diabetes, but other studies in Western populations reported no association [5,6,10,11]. An association between n-3 PUFA intake and the risk of type 2 diabetes was reported in Asian [15,16] but not in Western populations [6,8,17,18,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Another possible explanation is that there are different levels of n-3 PUFA in Asian and Western populations. Djoussé et al [10] found no association between plasma levels of n-3 PUFAs and the incidence of type 2 diabetes, but did observe a lower risk of type 2 diabetes in participants who were in the highest quartile of 22:5n3 and 22:6n3 plasma concentrations, suggesting that at certain levels, n-3 PUFA might reduce the risk of type 2 diabetes. Blood levels of 22:5n3 and 22:6n3 were 10% higher in the present study when compared to Western populations, and 8% higher than in Western populations in a Chinese study [27].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, blood levels of n-3 PUFA as a biomarker of n-3 PUFA intake were not associated with the risk of type 2 diabetes [5,6,10,11], except in a recent study in Finland [12]. The association has not been studied in Asians, but lower blood levels of n-3 PUFA were observed in Asians with than without type 2 diabetes [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Erythrocyte n-3 Polyunsaturated Fatty Acids and the Risk of Type 2 Diabetes in Koreans: A Case-Control Study

Park

2013

Ann Nutr Metab

View full text Add to dashboard Cite

Background: There is inconsistent epidemiologic evidence for an association between tissue levels of n-3 polyunsaturated fatty acids (PUFAs) and the risk of type 2 diabetes. The purpose of the present study was to investigate whether erythrocyte levels of n-3 PUFAs are negatively associated with the risk of type 2 diabetes and correlated with levels of glucose and HbA1c in Koreans. Methods: A total of 130 patients with type 2 diabetes and 260 age- and sex-matched controls participated in this study. Results: The risk of type 2 diabetes was negatively associated with erythrocyte levels of 22:5n3 and 22:6n3, which were negatively correlated with HbA1c levels after adjusting for age, sex and body mass index. Additionally, the risk of type 2 diabetes was negatively associated with erythrocyte levels of 18:0 and 20:4n6, but positively associated with erythrocyte levels of 16:0, 18:1n9, 18:3n3, 18:2n6, 18:3n6, n-6/n-3 PUFA ratio, 18:1t and 18:2n6t, and Δ-6 desaturase (18:3n6/18:2n6) and Δ-9 desaturase (18:1n9/18:0) activities. Conclusions: The risk of type 2 diabetes was negatively associated with erythrocyte levels of n-3 PUFA, which were negatively correlated with HbA1c levels in Koreans, suggesting that n-3 PUFAs might reduce the risk of type 2 diabetes in Asians.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Erythrocyte n-3 Polyunsaturated Fatty Acids and the Risk of Type 2 Diabetes in Koreans: A Case-Control Study

Park

2013

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Studies on fish consumption and type 2 diabetes are inconsistent: some show that higher dietary intake of omega 3s decreases the risk of type 2, some show no connection, and some even show that higher fish consumption increases the risk of type 2 diabetes [20,21]. It may be that the chemicals in fish can explain these inconsistencies.…”

Section: Chemicals and Omega-3smentioning

confidence: 99%

The Role of Nutrition in the Management of Diabetes Mellitus

Olabiyi¹,

Oguntibeju²

2013

Diabetes Mellitus - Insights and Perspectives

View full text Add to dashboard Cite

“…Humans can synthesize most fatty acids de novo but the health-promoting x-3 and x-6 polyunsaturated fatty acids (PUFAs) are exceptions that need to be sourced from the diet (Djoussé et al 2011). Once acquired, simple x-3 PUFAs such as a-linolenic acid can be converted into more complex very-long-chain polyunsaturated fatty acids (VLC-PUFAs) such as arachidonic acid (ARA), and these can be converted back to the simpler species.…”

Section: Essential Fatty Acidsmentioning

confidence: 99%

The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints

et al. 2012

View full text Add to dashboard Cite

Malnutrition is a prevalent and entrenched global socioeconomic challenge that reflects the combined impact of poverty, poor access to food, inefficient food distribution infrastructure, and an over-reliance on subsistence mono-agriculture. The dependence on staple cereals lacking many essential nutrients means that malnutrition is endemic in developing countries. Most individuals lack diverse diets and are therefore exposed to nutrient deficiencies. Plant biotechnology could play a major role in combating malnutrition through the engineering of nutritionally enhanced crops. In this article, we discuss different approaches that can enhance the nutritional content of staple crops by genetic engineering (GE) as well as the functionality and safety assessments required before nutritionally enhanced GE crops can be deployed in the field. We also consider major constraints that hinder the adoption of GE technology at different levels and suggest policies that could be adopted to accelerate the deployment of nutritionally enhanced GE crops within a multicomponent strategy to combat malnutrition.

show abstract

Plasma omega-3 fatty acids and incident diabetes in older adults

Abstract: With the use of objective biomarkers, long-chain n-3 FAs and ALA were not associated with a higher incidence of diabetes. Individuals with the highest concentrations of both types of FAs had lower risk of diabetes.

Cited by 108 publications

References 41 publications

Erythrocyte n-3 Polyunsaturated Fatty Acids and the Risk of Type 2 Diabetes in Koreans: A Case-Control Study

Erythrocyte n-3 Polyunsaturated Fatty Acids and the Risk of Type 2 Diabetes in Koreans: A Case-Control Study

The Role of Nutrition in the Management of Diabetes Mellitus

The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints

Contact Info

Product

Resources

About