Plasma oestrone and oestradiol concentrations throughout gestation in cattle: relationship to stage of gestation and fetal number

Patel, Osman V.; Takenouchi, Naoki; Takahashi, Toshio; Hirako, Makoto; Sasaki, Nobuo; Domeki, Ikuo

doi:10.1053/rvsc.1998.0254

Cited by 36 publications

(40 citation statements)

References 26 publications

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“…Afterward, the concentrations of all forms of oestrogens continue to increase, but at a more gradual rate until about day 250 (Echternkamp, 1992;Hoffmann et al, 1997;Patel et al, 1999). From about day 250 until the end of gestation, the concentrations of oestrogen rise sharply again, reaching peak levels at about 2-5 days pre-partum, and then falling abruptly to undetectable levels at parturition (Smith et al, 1973;Hoffmann et al, 1997;Patel et al, 1999). Generally, the concentrations of oestrogens are higher in Figure 1.…”

Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 90%

“…1). Although these start to increase from about days 60 to 80, the first sharp rise in oestrogen levels only commences at around days 100-120 (Dobson et al, 1993;Hoffmann et al, 1997;Patel et al, 1999;Hikaro et al, 2002). Afterward, the concentrations of all forms of oestrogens continue to increase, but at a more gradual rate until about day 250 (Echternkamp, 1992;Hoffmann et al, 1997;Patel et al, 1999).…”

Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 99%

“…Although these start to increase from about days 60 to 80, the first sharp rise in oestrogen levels only commences at around days 100-120 (Dobson et al, 1993;Hoffmann et al, 1997;Patel et al, 1999;Hikaro et al, 2002). Afterward, the concentrations of all forms of oestrogens continue to increase, but at a more gradual rate until about day 250 (Echternkamp, 1992;Hoffmann et al, 1997;Patel et al, 1999). From about day 250 until the end of gestation, the concentrations of oestrogen rise sharply again, reaching peak levels at about 2-5 days pre-partum, and then falling abruptly to undetectable levels at parturition (Smith et al, 1973;Hoffmann et al, 1997;Patel et al, 1999).…”

Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 99%

“…Progesterone and oestrogen profiles in bovine pregnancy. Schematic representation of the dynamic changes in the concentrations of progesterone, oestrone, and oestrone-sulphate in maternal blood during bovine pregnancy (adapted with data from Stabenfeldt et al, 1970;Edqvist et al, 1973;Smith et al, 1973;Echternkamp, 1992;Dobson et al, 1993;Hoffmann et al, 1997;Patel et al, 1999;Takenouchi et al, 2004). pregnancies with two or more foetuses than in pregnancies with a single foetus (Echternkamp, 1992;Dobson et al, 1993;Patel et al, 1999;Hikaro et al, 2002). The profiles represented in Figure 1 and described below are for singleton pregnancies.…”

Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 99%

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Multilevel regulation of steroid synthesis and metabolism in the bovine placenta

Nguyen

Conley

Soboleva

et al. 2012

Molecular Reproduction Devel

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SUMMARYSteroid hormones play critical roles in almost all physiological processes in male and female reproduction. In a normal pregnancy, the concentrations of steroid hormones in maternal and foetal blood vary with gestation in response to changing needs. The placenta plays a central role in producing the appropriate steroids to support the pregnancy by coordinating its own steroidogenic activity with that of the corpus luteum and responding to foetal signals. Although much is known about the steroidogenic potential of the bovine placenta, far less is known about how the placenta integrates the synthesis of steroids with their subsequent metabolism and clearance to achieve appropriate local and peripheral concentrations of steroids in maternal and foetal blood at each stage of gestation. This review focuses on the current knowledge of the temporal and spatial regulation and compartmentalization of the biochemical pathways by which potent steroid hormones are synthesized and metabolized in the bovine placenta. The aim is to increase our understanding of how the balance of synthesis and metabolism determines placental steroid output as it changes with development and differentiation, and how this is regulated in response to the variations in the foetal signals and luteal secretory activity. The review highlights knowledge gaps and suggests that mathematical modelling can help understand the effect of different levels of regulation on the steroidogenic output of an organ, such as the bovine placenta.

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Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 90%

Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 99%

Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 99%

Section: Concentrations Of Oestrogen In Maternal Bloodmentioning

confidence: 99%

See 2 more Smart Citations

Multilevel regulation of steroid synthesis and metabolism in the bovine placenta

Nguyen

Conley

Soboleva

et al. 2012

Molecular Reproduction Devel

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“…Fluorescence detection was done using Wallac Fluorometer Model 1234 (Wallac, Turku, Finland) 5 min after enhancement. E 2 assay following extraction: The E 2 extraction was performed with a slight modification as in the previous report [12]. Briefly, 100 µl of distilled water was added to aliquots of plasma (100 µl) prior to diethyl ether extraction.…”

Section: Direct E 2 Assay With Tr-fiamentioning

confidence: 99%

A Direct Time-Resolved Fluoroimmunoassay (TR-FIA) for Measuring Plasma Estradiol-17.BETA. Concentrations in Cattle

Takahashi

Hamanaka

Imai

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. A direct Time-Resolved Fluoroimmunoassay (TR-FIA) system for measuring estradiol-17β (E 2 ) in bovine plasma was developed and evaluated. A 100 µl sample of bovine plasma was used for a TR-FIA without prior extraction and purification. The doseresponse curves of reference standards ranged from 0.0625 to 10 pg/well. The minimum detectable concentration of this assay system was 0.625 pg/ml, and 19 pg/ml of E 2 caused a 50% reduction of maximum binding. The intra-and inter-assay coefficients of variation were 10.2 and 17.4%, respectively. The plasma E 2 concentrations measured by direct TR-FIA correlated closely with those measured after extraction (r=0.939). The results in the present study indicate that the TR-FIA reagent for E 2 , designed for human research can also be utilized, with some modification, for direct assaying in bovine plasma. This assay type seems to fulfill the requirements for safety, sensitivity, specificity, reproducibility and practical convenience. KEY WORDS: direct assay, estradiol-17β, TR-FIA.

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Postpartum Anestrus and its Management in Dairy Cattle

Ambrose

2014

Bovine Reproduction

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Plasma oestrone and oestradiol concentrations throughout gestation in cattle: relationship to stage of gestation and fetal number

Cited by 36 publications

References 26 publications

Multilevel regulation of steroid synthesis and metabolism in the bovine placenta

Multilevel regulation of steroid synthesis and metabolism in the bovine placenta

A Direct Time-Resolved Fluoroimmunoassay (TR-FIA) for Measuring Plasma Estradiol-17.BETA. Concentrations in Cattle

Postpartum Anestrus and its Management in Dairy Cattle

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