Plasma Observations in the Auroral and Polar Cap Region

Fennell, J. F.

doi:10.1007/978-94-009-5454-0_21

Space Plasma Simulations 1985

DOI: 10.1007/978-94-009-5454-0_21

|View full text |Cite

Plasma Observations in the Auroral and Polar Cap Region

J. F. Fennell

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2008

Publication Types

Select...

Other1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The LEO charging environment occurs in the auroral zones where electrons are accelerated down magnetic field lines from higher altitudes (>2,000 km) at moderately high latitudes at LEO altitudes (Croley et al, 1978;Fennell, 1985;Fennell et al, 2002). These accelerated electrons can charge dielectric surfaces or isolated conductors if they impinge on them.…”

mentioning

confidence: 99%

LEO Orbit Surface Charging and Its Relationship to Environment, Vehicle Geometry, and Ionospheric Conditions

Fennell¹,

Anderson²

2008

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY) 01-12-20072. REPORT TYPE (From -To) Annual DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERInstitute for Cancer Research Philadelphia, PA 19111 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTIncreased genomic instability arising from centrosomal amplification has been proposed to be an important factor causing development of traits associated with highly malignant ovarian tumors, including multidrug resistance and increased tendency to metastasis. This proposal addresses the hypothesized interaction between the Cas proteins (HEF1 and p130Cas), Aurora A (AurA) and Ajuba as being likely to contribute to genomic instability and metastatic properties of ovarian tumors. Our work in the second project period has defined and performed detailed analysis of the HEF1-AurA-Ajuba complex. This has allowed us to develop a model in which HEF1 and AurA mutually stabilize each other, and HEF1 and Ajuba synergize to promote AurA activation at mitotic entry. At mitotic exit, phosphorylation by AurA promotes HEF1 return to focal adhesions. Excess of HEF1 protects AurA from inhibition by targeted small molecule inhibitors. In the past two years, elevation of HEF1 has been established as important for metastasis and/or invasion in lung cancer, melanoma, and glioblastoma; our ongoing work on this project will determine whether this is also true for ovarian cancer. SUBJECT TERMSHEF1, Aurora-A, NEDD9, Ajuba Golemis, Erica INTRODUCTION:The goal of this proposal is to better understand factors leading to ovarian cancer development, with the intent of improving diagnosis and treatment for ovarian cancer. Our preliminary data defined the HEF1 member of the Cas protein family as a regulator of centrosomal dynamics and genomic instability through control of the Aurora A (AurA) kinase. Th...

show abstract

mentioning

confidence: 99%

LEO Orbit Surface Charging and Its Relationship to Environment, Vehicle Geometry, and Ionospheric Conditions

Fennell¹,

Anderson²

2008

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Plasma Observations in the Auroral and Polar Cap Region

Cited by 1 publication

References 92 publications

LEO Orbit Surface Charging and Its Relationship to Environment, Vehicle Geometry, and Ionospheric Conditions

LEO Orbit Surface Charging and Its Relationship to Environment, Vehicle Geometry, and Ionospheric Conditions

Contact Info

Product

Resources

About