Plasma norepinephrine, epinephrine, and dopamine ??-hydroxylase activity during exercise in man

Péronnet, François; Cléroux, Jean; Perrault, Hélène; Thibault, Guy; Cousineau, Denis; J, de Champlain; Jc, Guilland; Klepping, J

doi:10.1249/00005768-198512000-00011

Cited by 17 publications

(18 citation statements)

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“…An injection of adrenalin induces the same effects as exercise on the immune system (6,24). Blood concentrations of adrenalin are always under 0.1 ng/ml at rest and they reach levels ranging from 0.3 to 1.Ong/ml at the end of a strenuous exercise (12,14,25). On the other hand, the maximum peak of IL-1 is obtained using 0.Sng!ml of adrenalin (15).…”

Section: Discussionmentioning

confidence: 99%

Release of Cytokines by Blood Monocytes During Strenuous Exercise

et al. 1994

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During strenuous exercise in endurance athletes, monocytes are activated and there is an acute inflammation and hypoxemia possibly due to lesional pulmonary edema. IL-6 and TNF-alpha released by monocytes may be implicated in the acute phase of lesional pulmonary edema. A study was carried out to determine whether TNF-alpha and IL-6 are released during strenuous exercise, and, if adrenalin released during exercise alters their generation. Ten young and six master athletes underwent an incremental exercise test. Arterial blood was drawn at rest, at the end of the exercise, and 20 minutes afterwards. Monocytes were isolated and incubated for 18 hours in the presence or absence of adrenalin. Il-6 and TNF-alpha were measured in monocyte supernatants. The spontaneous release of IL-6 or TNF-alpha was increased in young athletes when compared to older subjects. The spontaneous release of TNF-alpha was increased, but not significantly, by exercise and there was no correlation between the release of IL-6 and TNF-alpha and lung function measured during hypoxemia. Adrenalin inhibited the release of IL-6 or TNF-alpha. Correlations were observed between the in vitro release of IL-6 or TNF-alpha and age, VO2max, maximal ventilation and maximal power output of the subjects.

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Section: Discussionmentioning

confidence: 99%

Release of Cytokines by Blood Monocytes During Strenuous Exercise

et al. 1994

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“…Likewise, rats exposed to treadmill running have increased Fos expression in the striatum area of the brain mediated through D1 receptors 93. Similarly human exercise training studies show dependent changes in neurotransmitter systems, including the dopamine system 10, 14, 21, 63, 77, 113, in response to exercise, and these cause and effect changes are likely due to dopamine's involvement in control of sympathetic nervous activity 99. In these particular studies dopamine was treated as the dependent variable in response to exercise, or training.…”

Section: Going Further: Linking the Dopamine System And Regulation Ofmentioning

confidence: 99%

Does the difference between physically active and couch potato lie in the dopamine system?

Knab¹,

Lightfoot²

2010

Int. J. Biol. Sci.

127

113

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Obesity and other inactivity related diseases are increasing at an alarming rate especially in Western societies. Because of this, it is important to understand the regulating mechanisms involved in physical activity behavior. Much research has been done in regard to the psychological determinants of physical activity behavior; however, little is known about the underlying genetic and biological factors that may contribute to regulation of this complex trait. It is true that a significant portion of any trait is regulated by genetic and biological factors. In the case of voluntary physical activity behavior, these regulating mechanisms appear to be concentrated in the central nervous system. In particular, the dopamine system has been shown to regulate motor movement, as well as motivation and reward behavior. The pattern of regulation of voluntary physical activity by the dopamine system is yet to be fully elucidated. This review will summarize what is known about the dopamine system and regulation of physical activity, and will present a hypothesis of how this signaling pathway is mechanistically involved in regulating voluntary physical activity behavior. Future research in this area will aid in developing personalized strategies to prevent inactivity related diseases.

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“…[55] Plasma catecholamine levels accurately reflect physiological stress and the activity of the sympathetic nervous system. [56] The response produced by this system varies with the tissue considered and with the level of training. During endurance events, exercise duration is the first element responsible for a rise in catecholamine levels during and after exercise.…”

Section: Parameters Relating To the Sympathetic Adrenergic System: Thmentioning

confidence: 99%

Physiological Demands of Running During Long Distance Runs and Triathlons

Hausswirth

Lehénaff

2001

Sports Medicine

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The aim of this review article is to identify the main metabolic factors which have an influence on the energy cost of running (Cr) during prolonged exercise runs and triathlons. This article proposes a physiological comparison of these 2 exercises and the relationship between running economy and performance. Many terms are used as the equivalent of 'running economy' such as 'oxygen cost', 'metabolic cost', 'energy cost of running', and 'oxygen consumption'. It has been suggested that these expressions may be defined by the rate of oxygen uptake (VO2) at a steady state (i.e. between 60 to 90% of maximal VO2) at a submaximal running speed. Endurance events such as triathlon or marathon running are known to modify biological constants of athletes and should have an influence on their running efficiency. The Cr appears to contribute to the variation found in distance running performance among runners of homogeneous level. This has been shown to be important in sports performance, especially in events like long distance running. In addition, many factors are known or hypothesised to influence Cr such as environmental conditions, participant specificity, and metabolic modifications (e.g. training status, fatigue). The decrease in running economy during a triathlon and/or a marathon could be largely linked to physiological factors such as the enhancement of core temperature and a lack of fluid balance. Moreover, the increase in circulating free fatty acids and glycerol at the end of these long exercise durations bear witness to the decrease in Cr values. The combination of these factors alters the Cr during exercise and hence could modify the athlete's performance in triathlons or a prolonged run.

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Plasma norepinephrine, epinephrine, and dopamine ??-hydroxylase activity during exercise in man

Cited by 17 publications

References 0 publications

Release of Cytokines by Blood Monocytes During Strenuous Exercise

Release of Cytokines by Blood Monocytes During Strenuous Exercise

Does the difference between physically active and couch potato lie in the dopamine system?

Physiological Demands of Running During Long Distance Runs and Triathlons

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