Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia

Neyal, Münife; Yimenicioglu, Fatih; Aydeniz, Ali; Taşkın, Abdullah; Sağlam, Sadullah; Çekmen, Mustafa; Neyal, Abdurrahman; Gürsoy, Savaş; Erel, Özcan; Balat, Ayşe

doi:10.1016/j.clineuro.2012.08.028

Cited by 48 publications

(38 citation statements)

References 22 publications

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“…Studies of oxidant stress and antioxidant status in patients with FMS have also revealed different results; some have demonstrated a decreased total antioxidant status compared with the control groups, 8,9,31,32 whereas other studies did not show a significant difference between the two groups. 10,33 Neyal et al 9 and Altindag and Celik 31 and Altindag et al 32 observed decreased total antioxidant and increased total oxidant levels in FMS patients.…”

Section: Discussionmentioning

confidence: 95%

“…10,33 Neyal et al 9 and Altindag and Celik 31 and Altindag et al 32 observed decreased total antioxidant and increased total oxidant levels in FMS patients. Conversely, Bozkurt et al 10 reported no significant differences between patients and controls' serum total antioxidant status.…”

Section: Discussionmentioning

confidence: 99%

“…There are studies indicating an imbalance between oxidants and antioxidants in patients with FMS. [7][8][9][10] The results are controversial. To the best of our knowledge, no report related to thiol/disulphide homeostasis in FMS has been published.…”

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confidence: 99%

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Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Fidan

Alkan²,

Uğurlu

et al. 2017

Arch Rheumatol

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Objectives: This study aims to investigate dynamic thiol/disulphide homeostasis in patients with fibromyalgia syndrome (FMS). Patients and methods: Fifty female patients with FMS (mean age 40.5±7.2 years; range 21 to 55 years) and 40 healthy female controls (mean age 39±9.4 years, range 22 to 55 years) were included in the study. Pain visual analog scale, tender points, Fibromyalgia Impact Questionnaire, and Beck Depression Inventory were evaluated. Age, body mass index (BMI), and symptom durations were also recorded. Native thiol, disulphide and total thiol levels were measured with a novel automated method. Results: Serum disulphide levels were 14.7±3.4 µmol/L and 22.2±3.6 µmol/L in the FMS and control groups, respectively (p<0.001). Native thiol levels were 452.1±33.8 µmol/L and 433.5±37.6 µmol/L in the FMS and control groups, (p=0.015), while total thiol levels were 481.7±35.6 µmol/L and 477.5±38.9 µmol/L in the FMS and control groups, respectively (p=0.593). In the FMS group, disulphide/native thiol percent ratios and disulphide/ total thiol percent ratios were statistically significantly lower and native/total thiol percent ratios were statistically significantly higher than those of the control group. There were no correlations between serum thiol/disulphide profiles and pain scores & clinical variables in patients with FMS. Conclusion: Because of the decreased disulphide and increased native thiol levels, the thiol/disulphide balance has shifted to the reductive side. This metabolic disturbance may have a role in the pathogenesis of FMS.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Fidan

Alkan²,

Uğurlu

et al. 2017

Arch Rheumatol

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“…FMS patients have higher oxidative stress index and lower total nitrite levels than healthy controls (Neyal et al, 2013). In particular, patients with FMS demonstrated higher serum prolidase activity, total oxidative status, and oxidative stress index than healthy controls, and serum prolidase activity positively correlated with pain and fatigue scores (Bozkurt et al, 2014).…”

Section: Pathogenesismentioning

confidence: 85%

Fibromyalgia Syndrome in Need of Effective Treatments

Theoharides

Tsilioni

Arbetman

et al. 2015

J Pharmacol Exp Ther

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Fibromyalgia syndrome (FMS) is a chronic, idiopathic condition of widespread musculoskeletal pain, affecting primarily women. It is clinically characterized by chronic, nonarticular pain and a heightened response to pressure along with sleep disturbances, fatigue, bowel and bladder abnormalities, and cognitive dysfunction. The diagnostic criteria have changed repeatedly, and there is neither a definitive pathogenesis nor reliable diagnostic or prognostic biomarkers. Clinical and laboratory studies have provided evidence of altered central pain pathways. Recent evidence suggests the involvement of neuroinflammation with stress peptides triggering the release of neurosenzitizing mediators. The management of FMS requires a multidimensional approach including patient education, behavioral therapy, exercise, and pain management. Here we review recent data on the pathogenesis and propose new directions for research and treatment.

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“…So we could not make any comments on the patients' variables in relation to demographic or clinical data that might explain the involvement of NO pathways in the natural course of migraine. NO may be involved in some other primary headache types (18)(19)(20), but probably not in the same manner as in migraine attacks (20). On the other hand, it is not clear yet whether NO involvement in primary headaches is the cause or the consequence.…”

Section: Discussionmentioning

confidence: 94%

Elevated plasma total nitrite levels may be related to migraine attacks

Neyal¹,

Geyik²,

Çekmen³

et al. 2014

Gaziantep Med J

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Both vascular and neuronal mechanisms are the main foci of investigation in defining the pathophysiology of migraine attacks. This study was designed to evaluate the possible role of nitric oxide (NO) in migraine patients in the natural course of unprovoked attacks and attack-free periods. The mean plasma nitrite levels of 26 migraine patients during attacks and attack-free periods were compared within group and with those of 26 healthy controls. Plasma total nitrite levels were measured by Greiss reaction. Mean plasma total nitrite levels of migraine patients during attacks and attack-free periods and of controls were 36.5±7.5 μmol/l, 27.81±4.8 μmol/l and 25.19±4.1 μmol/l, respectively. These results demonstrated that total nitrite levels during attacks were significantly higher in migraineurs than both during attack-free periods and those of controls (P=0.001 and P=0.001, respectively). No significant difference was observed between migraineurs during attack-free periods and controls in this regard (P=0.534). Based on these results, we suggest that NO pathway may play a key role in the pathogenesis of migraine attacks.

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Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia

Cited by 48 publications

References 22 publications

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

Fibromyalgia Syndrome in Need of Effective Treatments

Elevated plasma total nitrite levels may be related to migraine attacks

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