2021
DOI: 10.1016/j.parkreldis.2021.04.016
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Plasma NfL, clinical subtypes and motor progression in Parkinson's disease

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Cited by 29 publications
(22 citation statements)
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“…On the other, a recent work proposed Cys-C as a mediator of neurodegeneration, able to induct microglial activation and consequent neurotoxic factors' release in rat dopaminergic cell cultures [17]. The present study added an important piece to this complex picture, revealing a strong correlation between plasma levels of Cys-C and NfL, a highly reliable biomarker of neuronal damage [8,27,47]. This association is of particular relevance because constitutes the first evidence of a direct link between neurodegeneration and Cys-C, independently from peripheral inflammation.…”
Section: Discussionsupporting
confidence: 55%
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“…On the other, a recent work proposed Cys-C as a mediator of neurodegeneration, able to induct microglial activation and consequent neurotoxic factors' release in rat dopaminergic cell cultures [17]. The present study added an important piece to this complex picture, revealing a strong correlation between plasma levels of Cys-C and NfL, a highly reliable biomarker of neuronal damage [8,27,47]. This association is of particular relevance because constitutes the first evidence of a direct link between neurodegeneration and Cys-C, independently from peripheral inflammation.…”
Section: Discussionsupporting
confidence: 55%
“…Findings showed that PD patients with higher Cys-C levels exhibited faster motor progression over a 2-year follow-up, as measured by MDS-UPDRS-III changes, after adjusting for age, sex, disease duration, and peripheral inflammation. In addition, the present work provides the first evidence of a significant correlation between plasma levels of Cys-C and NfL, a well-known marker of axonal damage in neurodegenerative diseases [7, 8, 27, 28].…”
Section: Discussionmentioning
confidence: 92%
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“…As blood NFLs have a diagnostic accuracy similar to CSF NFLs, they may be a valid clinical tool in differential diagnosis between PD and APD [ 54 ]. Increased NFL levels were observed in patients with PD in connection with severe and long-term disease, in the context of the presence of dementia [ 55 ]. Although NFL in CSF and blood can differentiate between PD and APD, they cannot be used as a tool to differentiate between APD with synuclein depositions (MSA), and APD related to the depositions of pathologically changed protein tau (tauopathies) as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD).…”
Section: Parkinson’s Disease and Dementia With Lewy Bodies (Pd And Dlb)mentioning
confidence: 99%