Plasma neuropeptide-Y concentrations in humans exposed to military survival training

Morgan, Charles A.; Wang, Sheila; Southwick, Steven M.; Rasmusson, Ann M.; Hazlett, Gary; Hauger, Richard L.; Charney, Dennis S.

doi:10.1016/s0006-3223(99)00239-5

Cited by 267 publications

(179 citation statements)

References 31 publications

Supporting

Mentioning

166

Contrasting

Unclassified

Order By: Relevance

“…No significant changes in plasma NPY concentrations and no interrelations with metabolic factors, except b-OH-butyrate, or with leptin or insulin concentrations were found during fasting. Animal studies of fasting found increases in hypothalamic NPY mRNA (27); however, the exact nature of the relationship between central and peripheral measures of NPY is poorly understood at present (28). Further, in response to various psychological and/or physical factors, both an increase (18,19) and a decrease (20) in circulating NPY concentration have been reported in correlation with the noradrenaline release.…”

Section: Discussionmentioning

confidence: 99%

Orexin-A and leptin change inversely in fasting non-obese subjects

Kobashi

Matsumoto

Nishikata

et al. 2001

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Leptin, neuropeptide-Y (NPY) and orexin are peptides regulating energy metabolism and appetite control. NPY and orexin are mainly found in the central nervous system and they have also recently been found in the peripheral nervous system. We investigated how fasting affects changes in circulating concentrations of these peptides and their association with nutritional and metabolic parameters in humans. Design and methods: Ten non-obese female patients with psychosomatic disorders fasted for 7 or 10 days. Blood samples were collected at 0800 h before fasting, on the 3rd and 7th days during the fast (with an additional sample taken on the 10th day when the fasting continued for 10 days) and on the 3rd and 7th days of refeeding. We measured blood concentrations of orexin-A, NPY, leptin, adrenocorticotropin, cortisol, insulin, C-peptide, glucose, and b-hydroxybutyrate. Results: Body mass index and plasma leptin concentrations concomitantly and significantly decreased during fasting, whereas serum orexin-A concentrations significantly increased and were negatively correlated with plasma leptin concentrations. Plasma NPY concentrations decreased slightly but were not significantly different from the prefasting values, and no significant relationship with leptin or orexin-A was found. Orexin-A and leptin concentrations showed a significant inverse correlation with serum glucose, insulin, C-peptide, and b-hydroxybutyrate concentrations. Only changes in plasma leptin concentrations showed a significant negative correlation with serum cortisol concentrations. All the measured indices which changed during fasting returned to the prefasting concentrations by the 7th day of refeeding. Conclusion: Peripheral orexin-A and leptin concentrations inversely change during fasting, which is significantly correlated with energy metabolism in humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Orexin-A and leptin change inversely in fasting non-obese subjects

Kobashi

Matsumoto

Nishikata

et al. 2001

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Relatively higher NPY concentrations were associated with increased resilience and less psychological distress (7,8). Conversely, depleted plasma NPY levels correlated with poorer stress-handling ability and higher dissociation scores (7,8). With relevance to PTSD, baseline plasma NPY levels were found to be reduced (9) or unchanged (10) in PTSD patients as compared with healthy subjects.…”

mentioning

confidence: 94%

“…Additionally, data from American soldiers undergoing survival training demonstrated that acute uncontrollable stress significantly increases plasma NPY concentrations. Relatively higher NPY concentrations were associated with increased resilience and less psychological distress (7,8). Conversely, depleted plasma NPY levels correlated with poorer stress-handling ability and higher dissociation scores (7,8).…”

mentioning

confidence: 97%

Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder

Sah

Ekhator

Strawn

et al. 2009

Biological Psychiatry

130

View full text Add to dashboard Cite

show abstract

“…High levels of NPY are prognostic of a better psychological outcome following trauma, while reduced levels of NPY are strongly associated with increased anxiety levels, post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and suicide (7). Interestingly, in their studies on US soldiers undergoing survival training, Morgan et al have found that survival training increases the levels of NPY, with associated increases in psychological resilience (24,25).…”

Section: Does Resilience Matter In Spinal Cord Injury (Sci)?mentioning

confidence: 99%