Plasma neurofilament light chain is elevated in Niemann-Pick Type C but glial fibrillary acidic protein is not
Dhamidhu Eratne,
Courtney Lewis,
Wendy Kelso
et al.
Abstract:OBJECTIVENiemann-Pick Type C (NPC) is a genetic neurodegenerative lysosomal storage disorder commonly associated with psychiatric symptoms and delays to accurate diagnosis and treatment. This study investigated biomarker levels and diagnostic utility of plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in NPC compared to healthy controls.METHODSPatients with NPC were recruited from a specialist assessment and management service. Data was available from an age and sex-matched hea… Show more
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