Plasma needle forin vivomedical treatment: recent developments and perspectives

Abstract

In this paper we describe the hitherto unravelled facts on the interactions of a cold atmospheric plasma with living cells and tissues. A specially designed source, plasma needle, is a low-power discharge, which operates under the threshold of tissue damage. When applied properly, the needle does not cause fatal cell injury which would result in cell death (necrosis). Instead, it allows precise and localized cell removal by means of the so-called cell detachment. In addition, plasma can be used for bacterial disinfection. Because of mild treatment conditions, plasma disinfection can be performed in vivo, e.g. on wounds and dental cavities. Presently, one strives to obtain a better control of the operating device. Therefore, plasma has been characterized using a variety of diagnostics, and a smart system has been designed for the positioning of the device with respect to the treated surface.

Use of particle-in-cell simulations to improve the actinometry technique for determination of absolute atomic oxygen density

“…Atomic oxygen is critical for side-wall surface passivation enabling anisotropic trench etching via the formation of a dielectric oxide layer inside the microscopic etch trenches on the silicon substrates [5]. While many semiconductor plasmas tend to operate at low to medium pressures, recent development of industrial atmospheric plasma sources has seen high pressure plasmas containing oxygen used for applications such as the treatment of sensitive surfaces in the bio-medical industry [6]. The atomic oxygen radical has been identified as a key species in determining the behaviour of many of these processes and so there is much interest in developing a robust diagnostic capable of accurately monitoring absolute atomic oxygen number density values [O] in processing plasmas under a range of operating conditions.…”

Diagnostic based modeling for determining absolute atomic oxygen densities in atmospheric pressure helium-oxygen plasmas

“…The population dynamics of the upper O 3p 3 The production of reactive atomic oxygen in cold atmospheric pressure plasmas promises high potential for technological exploitation and is targeted for many temperature sensitive surface treatments in biomedicine. 1,2 Reliable determination of absolute atomic oxygen densities is vital for plasma source development and understanding of fundamental mechanisms. Recently, atomic oxygen densities have been measured using two-photon absorption laser-induced fluorescence ͑TALIF͒ spectroscopy.…”

Electron heating and mode transition in dual frequency atmospheric pressure argon dielectric barrier discharge

“…[1][2][3][4][5] The benefits from utilizing CAPs include the generation of a high density plasma at room temperature which reduces the need for expensive vacuum and confinement facilities. There have been many studies carried out in associated fields to advance practical applications and fundamental theoretical work.…”