Plasma n‐3 Polyunsaturated Fatty Acid and Cardiovascular Disease Risk Factors in Japanese, Korean and Mongolian Workers

Nogi, Akiko; Yang, Jianjun; Li, Limei; Yamasaki, Masayuki; Watanabe, Motoki; Hashimoto, Michio; Shiwaku, Kuninori

doi:10.1539/joh.49.205

Cited by 30 publications

(25 citation statements)

References 47 publications

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“…Diets rich in n-3 fatty acids have been shown to prevent obesity better than other subclasses of PUFA (56,116) . This effect has been reported in studies in human subjects (57,138,139) , mice (48,60) and rats (62,63,65,66,102) . In most of the animal studies lower fat deposition in subjects fed n-3 fatty acids was shown despite comparable food and energy intake among the groups (48,60,62,65,66) ( Table 1; lines 12, 33, 23, 22 and 14, respectively); therefore this effect can be related to the metabolic effects of n-3 fats.…”

supporting

confidence: 70%

High-fat diet-induced obesity in animal models

2010

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Epidemiological studies have shown a positive relationship between dietary fat intake and obesity. Since rats and mice show a similar relationship, they are considered an appropriate model for studying dietary obesity. The present paper describes the history of using high-fat diets to induce obesity in animals, aims to clarify the consequences of changing the amount and type of dietary fats on weight gain, body composition and adipose tissue cellularity, and explores the contribution of genetics and sex, as well as the biochemical basis and the roles of hormones such as leptin, insulin and ghrelin in animal models of dietary obesity. The major factors that contribute to dietary obesity -hyperphagia, energy density and post-ingestive effects of the dietary fat -are discussed. Other factors that affect dietary obesity including feeding rhythmicity, social factors and stress are highlighted. Finally, we comment on the reversibility of high-fat diet-induced obesity.

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supporting

confidence: 70%

High-fat diet-induced obesity in animal models

2010

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“…Previously, we observed that the average erythrocyte levels of n-3 PUFA were approximately 10% among Koreans, which is similar to the Japanese rate but higher than in Western populations [20,21]. The Korean National Health and Nutrition Examination survey consistently reported that Korean adults consumed higher amounts of fish (50 g/day) than did Western populations [22].…”

Section: Introductionmentioning

confidence: 68%

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Lee

Park

2013

Ann Nutr Metab

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Background: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that result in chronic inflammation of the joints. n-3 polyunsaturated fatty acids (PUFAs) have been suggested to play a role in the pathogenesis and clinical course of RA. The purpose of the present study was to investigate whether erythrocyte levels of n-3 PUFA are associated with an increased risk of RA and whether this could potentially serve as an indicator of RA disease activity in Korean women. Methods: A total of 100 female RA patients and 100 healthy women were enrolled into this study. Erythrocyte fatty acid composition and RA disease activity were evaluated in all patients. Results: Erythrocyte levels of α-linolenic acid (ALA; 18:3n3), eicosapentaenoic acid (EPA; 20:5n3), and the omega-3 index [EPA + docosahexaenoic acid (DHA)] were significantly lower in RA patients than in healthy controls. Multivariable-adjusted regression analysis showed that the levels of ALA, EPA, and the ratio of EPA to arachidonic acid were negatively associated with the risk of RA after adjusting for body weight and smoking status. Additionally, the concentration of prostaglandin E₂ was significantly decreased with increased levels of erythrocyte DHA among RA patients. Conclusions: Erythrocyte levels of EPA and ALA were negatively associated with the risk of RA in Korean women, which may be related to eicosanoid metabolism.

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“…Our Mongolian patients with both HT and DM presented higher levels of BMI and insulin, a suggestive parameter of greater insulin resistance, in comparison to the Japanese patients. Furthermore, an earlier work has reported greater levels of insulin resistance in Mongolian workers than Japanese workers 21) . However, interestingly, our study showed that significant differences in CRP and CAVI between Japanese and Mongolian patients were maintained, even after adjusting for factors related to insulin resistance (e.g., BMI, HOMA-IR) and/or other factors, such as blood pressure levels.…”

Section: Discussionmentioning

confidence: 90%

Comparative Study of Atherosclerotic Parameters in Mongolian and Japanese Patients with Hypertension and Diabetes Mellitus

Uurtuya

Kotani

Taniguchi

et al. 2010

JAT

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Plasma n‐3 Polyunsaturated Fatty Acid and Cardiovascular Disease Risk Factors in Japanese, Korean and Mongolian Workers

Abstract: Plasma n-3 Polyunsaturated Fatty Acid and Cardiovascular Disease Risk Factors in Japanese, Korean and Mongolian Workers: Akiko NOGI, et al.

Cited by 30 publications

References 47 publications

High-fat diet-induced obesity in animal models

High-fat diet-induced obesity in animal models

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Comparative Study of Atherosclerotic Parameters in Mongolian and Japanese Patients with Hypertension and Diabetes Mellitus

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