Plasma Myeloperoxidase and Lactoferrin Measured by Radioimmunoassay: Relations to Neutrophil Kinetics

Hansen, Niels Ebbe; Malmquist, Jörgen; Thorell, Jan I.

doi:10.1111/j.0954-6820.1975.tb19572.x

Cited by 106 publications

(12 citation statements)

References 24 publications

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“…Plasma lactoferrin concentrations may or may not correlate with the neutrophil count (Hansen et al, 1975;Olofsson et al, 1977;Baynes et al, 1986). This depends on the extent of degranulation and perhaps on the contribution of other organs, such as bone marrow, endometrium (Masson et al, 1968) and placenta (Niemela et al, 1989).…”

Section: Sources Of Lactoferrin In the Organismmentioning

confidence: 99%

Lactoferrin: a review

Adlerova¹,

Bartošková²,

Faldyna³

2008

Vet. Med. - Czech

257

209

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This review discusses the biological properties of the glycoprotein lactoferrin. Lactoferrin has been identified in secretions from exocrine glands and in specific granules of neutrophils. After degranulation, neutrophils become the main source of lactoferrin in blood plasma. Lactoferrin possesses various biological functions, including roles in iron metabolism, cell proliferation and differentiation, and antibacterial, antiviral, and antiparasitic activity. Many of these functions do not appear to be connected with its iron binding ability. Of late, lactoferrin concentrations have been measured mostly in humans but also in some other species. However, the relationship between its concentration and physiological or pathological effects on body functions is not yet well characterised.

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Section: Sources Of Lactoferrin In the Organismmentioning

confidence: 99%

Lactoferrin: a review

Adlerova¹,

Bartošková²,

Faldyna³

2008

Vet. Med. - Czech

257

209

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“…In the present investigation the level of P-Lactoferrin as measured by a sensitive immunoassay method did not vary with differences in body iron content. Since P-Lactoferrin accurately reflects the granulocyte mass (25) and since there has been no evidence to suggest that granulocyte mass or turnover are altered in the presence of iron deficiency, it would appear reasonable to assume that intracellular lactoferrin concentration is not grossly affected by the presence of iron depletion or even frank iron deficiency.…”

Section: Discussionmentioning

confidence: 99%

Lack of correlation between iron stores and plasma lactoferrin concentration

Baynes

Bezwoda

Derman

et al. 1986

Scandinavian Journal of Haematology

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Plasma lactoferrin concentration and indices of iron nutrition including P‐Ferritin, P‐iron, total iron binding capacity and percentage saturation were measured in 75 otherwise normal females. This was done in order to evaluate previous reports that neutrophil lactoferrin content was altered by variations in iron storage status. Since P‐Lactoferrin is derived from and hence reflects neutrophil lactoferrin content it would seem reasonable to assume that P‐Lactoferrin would vary in accordance with iron stores. However, there was no statistically significant difference in P‐Lactoferrin concentration between iron deficient subjects and those who were iron replete. Furthermore, there was no statistically significant correlation between any iron related parameter and P‐Lactoferrin concentration.

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“…Interpretation of the results of this preliminary study is rather difficult. The relative increase of S-LF, in relation to the low neutrophil counts, could be explained not only by the existence of an increased neutrophil margination (8,9), but also by an increased release of lactoferrin from the neutrophils because of increased breakdown (10) or even increased activation in vivo (1 1, 12). This could also explain a relative and sometimes absolute increase in S-MPO.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of lactoferrin and myeloperoxidase in chronic idiopathic and secondary neutropenia

Veen

Borne

1986

Scandinavian Journal of Haematology

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In 20 patients with chronic neutropenia, serum lactoferrin (S‐LF) and serum myeloperoxidase (S‐MPO) levels were assessed. By immunofluorescence, granulocyte‐bound immunoglobulins were detected in 12 patients, whereas circulating immune complexes were found in the blood of 8 patients by the 125‐I‐Clq‐binding test (Clq‐BT). In both groups of patients, there was a relative increase of S‐LF and a relative or sometimes absolute increase of S‐MPO. In the latter group, results of the Clq‐BT correlated positively with S‐MPO but negatively with neutrophil counts. No correlations between S‐LF or S‐MPO and the results of the granulocyte immunofluorescence test were found. Our results suggest that S‐LF and S‐MPO levels may be helpful in the further study of patients with chronic neutropenia, to gain more insight into the pathogenetic mechanisms operative in this disease.

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Plasma Myeloperoxidase and Lactoferrin Measured by Radioimmunoassay: Relations to Neutrophil Kinetics

Cited by 106 publications

References 24 publications

Lactoferrin: a review

Lactoferrin: a review

Lack of correlation between iron stores and plasma lactoferrin concentration

Serum levels of lactoferrin and myeloperoxidase in chronic idiopathic and secondary neutropenia

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