Plasma mono-, di- and triacylglycerol measurements in a study of fat uptake by human adipose tissue <i>in vivo</i>

Fielding, Barbara A.; Humphreys, Sandy M.; Shadid, Samiah; Frayn, Keith N.

doi:10.1042/bst023487s

Cited by 7 publications

(2 citation statements)

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“…The key factors in the concentration regulations are the inhibition of hormone-sensitive lipase by insulin [3]. After the hydrolysis of chylomicron-TAG by LPL in adipose tissue, there seems to be regulation of the change of the fatty acids released: uptake and esterification by adipocytes or release into plasma as NEFA [4,5]. There is no indirect evidence for fatty acids to take effect at this branch-point of uptake and esterification.…”

Section: Introductionmentioning

confidence: 99%

An Inverse Problem for the Absorption of Fatty Acid

Hai

Kokulan

Chen

et al. 2015

Journal of Algorithms & Computational Technology

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The mathematical model of fatty acid kinetics in plasma is considered. The model is based on physiological knowledge and constructed by means of experimental data. In order to estimate the unknown parameters in the model, methods of inverse problems are used with measurements and ordinary differential equations governing the kinetics. Different sets of experimental data were used to establish the unknown parameters in the mathematical model. This enables one to understand the absorption process of nutrients and provide a computational estimation for the absorption rate.

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Section: Introductionmentioning

confidence: 99%

An Inverse Problem for the Absorption of Fatty Acid

Hai

Kokulan

Chen

et al. 2015

Journal of Algorithms & Computational Technology

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“…The fatty acid at the sn-2 position has to isomerize to the sn-1 or -3 position in order to be hydrolysed, or there may be uptake of the resulting 2-monoacylglycerol (MAG;Braun & Severson, 1992). Whichever occurs, there appears to be no net production of plasma MAG during rapid LPL action in human adipose tissue in vivo (Fielding et al 1995).…”

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confidence: 99%

The effect of triacylglycerol-fatty acid positional distribution on postprandial metabolism in subcutaneous adipose tissue

et al. 1998

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We hypothesized that fatty acids at the sn-2 position of chylomicron triacylglycerol are preferentially released into the venous plasma (rather than being taken up and stored in the adipocytes) after hydrolysis by lipoprotein lipase (EC 3.1.1.34) in adipose tissue. Arteriovenous differences across adipose tissue were studied in eight healthy subjects on two occasions for 6 h after ingestion of different structured triacylglycerols rich in palmitic acid either at the sn-2 or the sn-1,3 positions. In particular the specific fatty acids making up lipoprotein fractions and plasma non-esterified fatty acids were analysed. After the different meals there were no differences between either postprandial arterialized or venous plasma metabolite concentrations. Chylomicron triacylglycerol extraction in adipose tissue was the same following the two types of fat. There was no difference between the specific fatty acid composition of the postprandial non-esterified fatty acid release from adipose tissue after ingestion of the two triacylglycerols, indicating that there was no preferential release of a saturated fatty acid at the sn-2 position. Triacylglycerols: Adipose tissue: Lipoprotein lipase: Postprandial metabolism

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