Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction

Li, Huixian; Zhang, Pengxiang; Li, Fangjiang; Yuan, Guili; Wang, Xiaoyuan; Zhang, Aiai; Li, Feixing

doi:10.1155/2019/5012648

Cited by 34 publications

(39 citation statements)

References 43 publications

(44 reference statements)

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“…MiR-150 was associated with inflammation and was reported to be implicated in the pathogenesis of various cardiovascular diseases; however, the expression profile of circulating miR-150 in cardiac injury could vary among different studies. Indeed, Devaux et al observed that low circulating levels of miR-150 are associated with adverse left ventricular remodeling after first STEMI [23], while circulating miR-150 was overexpressed in both STEMI and NSTEMI patients and in the early stage of AMI patients compared to control subjects [24]. Interestingly, studies indicated that miR-150 exhibited a cardio-protective role by inhibiting monocyte accumulation and cell death in a mouse model of acute myocardial infarction [25].…”

Section: Discussionmentioning

confidence: 99%

Identification of a miRNA Based-Signature Associated with Acute Coronary Syndrome: Evidence from the FLORINF Study

Elbaz

Faccini

Laperche

et al. 2020

JCM

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Background: The discovery of novel biomarkers that improve risk prediction models of acute coronary syndrome (ACS) is needed to better identify and stratify very high-risk patients. MicroRNAs (miRNAs) are essential non-coding modulators of gene expression. Circulating miRNAs recently emerged as important regulators and fine-tuners of physiological and pathological cardiovascular processes; therefore, specific miRNAs expression profiles may represent new risk biomarkers. The aims of the present study were: (i) to assess the changes in circulating miRNAs levels associated with ACS and (ii) to evaluate the incremental value of adding circulating miRNAs to a clinical predictive risk model. Methods and Results: The study population included ACS patients (n = 99) and control subjects (n = 103) at high to very high cardiovascular risk but without known coronary event. Based on a miRNA profiling in a matched derivation case (n = −6) control (n = 6) cohort, 21 miRNAs were selected for validation. Comparing ACS cases versus controls, seven miRNAs were significantly differentially expressed. Multivariate logistic regression analyses demonstrated that among the seven miRNAs tested, five were independently associated with the occurrence of ACS. A receiver operating characteristic curve analysis revealed that the addition of miR-122 + miR-150 + miR-195 + miR-16 to the clinical model provided the best performance with an increased area under the curve (AUC) from 0.882 to 0.924 (95% CI 0.885–0.933, p = 0.003). Conclusions: Our study identified a powerful signature of circulating miRNAs providing additive value to traditional risk markers for ACS.

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Section: Discussionmentioning

confidence: 99%

Identification of a miRNA Based-Signature Associated with Acute Coronary Syndrome: Evidence from the FLORINF Study

Elbaz

Faccini

Laperche

et al. 2020

JCM

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“… hsa-miR-138 Promotes glioma angiogenesis through miR-138/HIF-1α/VEGF axis [ 87 ], upregulated after the induction of myocardial infarction [ 88 ]. hsa-miR-150 Inactivates VEGFA/VEGFR2 and the downstream Akt/mTOR signaling pathway in colorectal cancer [ 89 ], marker for early diagnosis of AMI [ 90 ], underexpression of this miRNA promotes proliferation and metastasis of gastric cancer [ 91 ]. hsa-miR-339 Overexpression of this miRNA can inhibit HCC cell invasion [ 92 ].…”

Section: Abdominal Aorta Aneurysm and Control Groups Constructionmentioning

confidence: 99%

Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm

Zalewski

Ruszel

Stępniewski

et al. 2020

JCM

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Abdominal artery aneurysm (AAA) refers to abdominal aortic dilatation of 3 cm or greater. AAA is frequently underdiagnosed due to often asymptomatic character of the disease, leading to elevated mortality due to aneurysm rupture. MiRNA constitute a pool of small RNAs controlling gene expression and is involved in many pathologic conditions in human. Targeted panel detecting altered expression of miRNA and genes involved in AAA would improve early diagnosis of this disease. In the presented study, we selected and analyzed miRNA and gene expression signatures in AAA patients. Next, generation sequencing was applied to obtain miRNA and gene-wide expression profiles from peripheral blood mononuclear cells in individuals with AAA and healthy controls. Differential expression analysis was performed using DESeq2 and uninformative variable elimination by partial least squares (UVE-PLS) methods. A total of 31 miRNAs and 51 genes were selected as the most promising biomarkers of AAA. Receiver operating characteristics (ROC) analysis showed good diagnostic ability of proposed biomarkers. Genes regulated by selected miRNAs were determined in silico and associated with functional terms closely related to cardiovascular and neurological diseases. Proposed biomarkers may be used for new diagnostic and therapeutic approaches in management of AAA. The findings will also contribute to the pool of knowledge about miRNA-dependent regulatory mechanisms involved in pathology of that disease.

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“…Seven studies performed miRNA screening to compare blood-based miRNAs between AMI patients and control groups (Adachi et al, 2010 ; D'Alessandra et al, 2010 ; Meder et al, 2011 ; Li C. et al, 2013 ; Hsu et al, 2014 ; Huang et al, 2014 ; Li et al, 2015 ). Fifty-one articles identified miRNAs based on their own previous studies or based on the literature (Ai et al, 2010 ; Cheng et al, 2010 ; Corsten et al, 2010 ; Wang et al, 2010 , 2011 , 2013 , 2014 , 2016 , 2019 ; Gidlöf et al, 2011 , 2013 ; Zile et al, 2011 ; Devaux et al, 2012 , 2015 ; Long et al, 2012a , b ; Li Y. Q. et al, 2013 ; Lu et al, 2013 ; Olivieri et al, 2013 ; He et al, 2014 ; Li L. M. et al, 2014 ; Li Z. et al, 2014 ; Peng et al, 2014 ; Xiao et al, 2014 ; Białek et al, 2015 ; Chen et al, 2015 ; Gao et al, 2015 ; Han et al, 2015 ; Ji et al, 2015 ; Liu et al, 2015 , 2018 ; Yao et al, 2015 ; Zhang L. et al, 2015 ; Zhang R. et al, 2015 ; Ke-Gang et al, 2016 ; Shalaby et al, 2016 ; Yang et al, 2016 , 2017 ; Zhang et al, 2016 , 2018 ; Zhu et al, 2016 ; Guo et al, 2017 ; Agiannitopoulos et al, 2018 ; Fawzy et al, 2018 ; Yi and An, 2018 ; Bukauskas et al, 2019 ; Li H. et al, 2019 ; Li P. et al, 2019 ; Xue et al, 2019a , b …”

Section: Resultsmentioning

confidence: 99%

Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

Zhai

Hou

et al. 2020

Front. Physiol.

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Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from the last ten years. Methods: MEDLINE, the Cochrane Central database, and EMBASE were searched between January 2010 and December 2019. Studies that assessed the diagnostic accuracy of circulating microRNAs in AMI were chosen. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and area under the curve (AUC) were used to assess the test performance of miRNAs. Results: A total of 58 studies that included 8,206 participants assessed the diagnostic accuracy of circulating miRNAs in AMI. The main results of the meta-analyses are as follows: (1) Total miRNAs: the overall pooled sensitivity and specificity were 0.82 (95% CI: 0.79-0.85) and 0.87 (95% CI: 0.84-0.90), respectively. The AUC value was 0.91 (95% CI: 0.88-0.93) in the overall summary receiver operator characteristic (SROC) curve. (2) The panel of two miRNAs:

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Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction

Cited by 34 publications

References 43 publications

Identification of a miRNA Based-Signature Associated with Acute Coronary Syndrome: Evidence from the FLORINF Study

Identification of a miRNA Based-Signature Associated with Acute Coronary Syndrome: Evidence from the FLORINF Study

Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm

Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

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