Plasma Methionine After Oral Administration of DL-Methionine in Human Subjects

Harper, Harold A.; Uyeyama, Kahn

doi:10.3181/00379727-68-16462

Cited by 8 publications

(3 citation statements)

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“…It may have been the result of slow uptake ofamino acid bya diseased liver (Folin and Berglund, 1922;Bernhart and Schneider, 1943;Harper and Uyeyama, 1948;Mellinkoff, Jenden, and Frankland, 1954;Richmond and Girdwood, 1962). Amino acid tolerance tests were once used as tests of liver function.…”

Section: Results In Patients With Gastrointestinal Diseasementioning

confidence: 99%

“…Though the test has been used sporadically ever since in the investigation of gastrointestinal disease, particularly tropical sprue, pancreatic insufficiency, and intestinal resections (Erf and Rhoads, 1940;West, Wilson, and Eyles, 1946;Drew, Dixon, and Samuel, 1947;Anfanger and Heavenrich, 1949;Althausen, Doig, Uyeyama, and Weiden, 1950;Saint and Weiden, 1952;Butterworth, Santini, and Perez-Santiago, 1958), it has never become generally popular, nor has the similar methionine tolerance test (Harper and Uyeyama, 1948;Althausen, Uyeyama, and Simpson, 1949). The published normal values for both these tests are based on few observations, and in several cases these are quite inadequately reported, only mean values being given.…”

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confidence: 99%

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Absorption and malabsorption of glycine and glycine peptides in man.

Craft¹,

Geddes²,

Hyde³

et al. 1968

Gut

153

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Section: Results In Patients With Gastrointestinal Diseasementioning

confidence: 99%

mentioning

confidence: 99%

Absorption and malabsorption of glycine and glycine peptides in man.

Craft¹,

Geddes²,

Hyde³

et al. 1968

Gut

153

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“…Despite extensive studies of amino acid transport in a variety of preparations, information on amino acid absorption by the human small intestine is limited (6)(7)(8)(9)(10). We studied the pattern of L-methionine absorption in the human small intestine and found differences in transport characteristics between the proximal and distal segments.…”

Section: Introductionmentioning

confidence: 99%

Absorption of l-methionine from the human small intestine

Schedl¹,

Pierce²,

Rider³

et al. 1968

J. Clin. Invest.

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A B S T R A C T Absorption of L-methionine was measured in all parts of the human small intestine using transintestinal intubation and perfusion. In four normal subjects, adsorption was higher in the proximal than in the distal intestine. In two patients with nontropical sprue in relapse, there was a proximal zone of low absorption with higher absorption distally. In all parts of the small intestine, absorption showed rate-limiting kinetics as methionine concentration was increased. In normal subjects, the proximal Km (Michaelis constant) was more than 3 times higher than the distal, which suggests a difference in transport mechanisms between the two segments.

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