Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome

Panidis, Dimitrios; Rousso, David; Koliakos, George; Kourtis, Anargyros; Katsikis, Ilias; Farmakiotis, Dimitrios; Votsi, Elissavet; Diamanti-Kandarakis, Evanthia

doi:10.1016/j.fertnstert.2005.11.044

Cited by 87 publications

(76 citation statements)

References 33 publications

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“…Kisspeptin-13 has been detected in peripheral plasma (Horikoshi et al 2003, Panidis et al 2006, where its levels correlate negatively with fasting plasma insulin levels (Panidis et al 2006). Plasma kisspeptin concentrations are in the picomolar range, much lower than the concentrations employed in this study.…”

Section: Meansgsemcontrasting

confidence: 52%

Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas

Silvestre

Egido²,

Hernández³

et al. 2007

Journal of Endocrinology

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Kisspeptins are a family of peptides encoded by the KISS1 gene, which binds to G-protein-coupled receptor (GPR54), an orphan GPR54 related to galanin receptors. Endogenous forms composed of 54, 14, and 13 amino acids have been identified. Kisspeptin and GPR54 mRNAs have been detected in pancreatic B and A cells. Furthermore, kisspeptin-54 has been shown to slightly stimulate the last phase of glucose-induced insulin secretion in mouse and human islets and to inhibit insulin release in MIN6 cells. We have investigated the effect of kisspeptin-13 on insulin, glucagon, and somatostatin secretion. The study was performed in the perfused rat pancreas. Glucose, arginine, carbachol, and exendin-4 were used as secretagogues. Hormones were measured by RIA. Kisspeptin-13 reduced glucose-induced insulin secretion in a dose-dependent manner (IC 50 Z1 . 2 nM) and inhibited the insulin responses to both carbachol and exendin-4. Kisspeptin-13 blocked arginine-induced insulin secretion without affecting the glucagon or somatostatin responses to this amino acid, thus indicating that kisspeptin-13 influences B cells directly, rather than through an A-or D-cell paracrine effect. The reduction of the insulin response to exendin-4 induced by kisspeptin-13 was also observed in pertussis toxin-treated rats, thus suggesting an inhibition independent of G i proteins. In view of the potent insulinostatic effect of kisspeptin-13, it is tempting to speculate that kisspeptins may be implicated in the regulation of B-cell secretion.

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Section: Meansgsemcontrasting

confidence: 52%

Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas

Silvestre

Egido²,

Hernández³

et al. 2007

Journal of Endocrinology

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“…Consistent with our findings, Panidis et al 18 observed a negative correlation between BMI and plasma kisspeptin levels in women with PCOS. These findings contrast with the significant positive correlation be-tween BMI and visceral adipose tissue KISS1 mRNA levels in adult women as observed by Cockwell et al 19 Experimental studies have further confirmed that kisspeptin is expressed in adipose tissue and that kisspeptin receptors in adipose tissue are exposed, under some circumstances, to circulating kisspeptin.…”

Section: Discussionsupporting

confidence: 93%

“…In a recent work, Kanasaki et al 7 found no correlation of serum kisspeptin levels with levels of LH and FSH in normally menstruating women, pregnant women, postmenopausal women, patients with premature ovarian failure or idiopathic hypogonadotropic hypogonadism. Similarly, Panidis et al 18 reported no significant correlation between plasma kisspeptin and LH levels in women with polycystic ovary syndrome (PCOS) and controls.…”

Section: Discussionmentioning

confidence: 98%

Serum kisspeptin concentrations are negatively correlated with body mass index in adolescents with anorexia nervosa and amenorrhea

Bacopoulou

Lambrou²,

Rodanaki

et al. 2017

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“…In addition, Panidis et al (2006) reported raised levels of KP-54 in normal-weight subjects with polycystic ovary syndrome, which correlates with its association with leptin and obesity. However, these results should be interpreted with caution owing to the different assays used.…”

Section: Other Pathophysiologiesmentioning

confidence: 85%

International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin Receptor Nomenclature, Distribution, and Function

Kirby

Maguire²,

Colledge³

et al. 2010

Pharmacol Rev

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Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome

Cited by 87 publications

References 33 publications

Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas

Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas

Serum kisspeptin concentrations are negatively correlated with body mass index in adolescents with anorexia nervosa and amenorrhea

International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin Receptor Nomenclature, Distribution, and Function

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