Plasma Metalloproteinase-12 and Tissue Inhibitor of Metalloproteinase-1 Levels and Presence, Severity, and Outcome of Coronary Artery Disease

Jguirim-Souissi, Imen; Jelassi, Awatef; Addad, Faouzi; Hassine, Majed; Najah, Mohamed; Hamda, Khaldoun Ben; Maatouk, Faouzi; Farhat, M. Ben; Bouslema, Ali; Rouis, Mustapha; Slimane, Mohamed Naceur

doi:10.1016/j.amjcard.2007.01.069

Cited by 21 publications

(12 citation statements)

References 26 publications

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“…The reason for this difference remains to be elucidated, but it is possible that much of the circulating MMP-12 in subjects with diabetes mellitus originates from other tissues than atherosclerotic lesions. In line with the present findings, Jguirim-Souissi and coworkers 24 observed increased plasma levels of MMP-12 patients with CVD as compared with healthy controls. They were, however, unable to demonstrate a significant correlation between MMP-12 levels and the severity of coronary disease, but this could be because of the relative low number of subjects studied (n=34).…”

Section: Discussionsupporting

confidence: 79%

“…31 It remains to be clarified whether the present findings are a reflection of this. In contrast to some previous studies, 24,32 we did not find lower MMP levels in subjects treated with statins. This may be explained by the fact that patients treated with statins had more CVD and that this may have counteracted any MMP-lower effect of statin treatment.…”

Section: Arterioscler Thromb Vasc Biolcontrasting

confidence: 56%

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Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

Gonçalves

Bengtsson

Colhoun³

et al. 2015

ATVB

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Objective— Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus. Approach and Results— Plasma levels of MMP-1, -3, -7, -10, and -12 were analyzed by the Proximity Extension Assay technology in 1500 subjects participating in the SUMMIT (surrogate markers for micro- and macrovascular hard end points for innovative diabetes tools) study, 384 incident coronary cases, and 409 matched controls in the Malmö Diet and Cancer study and in 205 carotid endarterectomy patients. Plasma MMP-7 and -12 were higher in subjects with type 2 diabetes mellitus, increased with age and impaired renal function, and was independently associated with prevalent cardiovascular disease, atherosclerotic burden (as assessed by carotid intima-media thickness and ankle-brachial pressure index), arterial stiffness, and plaque inflammation. Baseline MMP-7 and -12 levels were increased in Malmö Diet and Cancer subjects who had a coronary event during follow-up. Conclusions— The plasma level of MMP-7 and -12 are elevated in type 2 diabetes mellitus, associated with more severe atherosclerosis and an increased incidence of coronary events. These observations provide clinical support to previous experimental studies, demonstrating a role for these MMPs in plaque development, and suggest that they are potential biomarkers of atherosclerosis burden and cardiovascular disease risk.

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Section: Discussionsupporting

confidence: 79%

Section: Arterioscler Thromb Vasc Biolcontrasting

confidence: 56%

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

Gonçalves

Bengtsson

Colhoun³

et al. 2015

ATVB

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“…One of these proteins is tissue inhibitor of metalloproteinases 1 (TIMP-1), which is a 25 kDa glycoprotein that inhibits most of the matrix metalloproteinases (MMPs). TIMP-1 has been proposed as an important plasma biomarker in patients with colorectal cancer [3,4], breast cancer [5,6], lung cancer [7][8][9], ovarian cancer [10], cardiovascular diseases [11][12][13][14] and types 1 and 2 diabetes [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Identifying sources and estimating glandular output of salivary TIMP‐1

Holten-Andersen

Jensen

Bardow

et al. 2008

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Elevated TIMP-1 levels have also been shown to predict worse outcome in breast cancer patients [7] . Furthermore, TIMP-1 plasma levels seem to play an important role in metabolic disorders, such as diabetes and adiposity [8][9][10] , as well as in patients with cardiac disease [11][12][13][14][15] and sepsis [16] . In addition to these promising investigations, some authors have presented results indicating that TIMP-1 levels differ depending on pre-and perianalytical conditions [17][18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Dependence of TIMP-1 Plasma Levels on Preanalytical Specimen Handling

Dresse¹,

Nagel²,

Ganser³

et al. 2008

Tumor Biol

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Background: Tissue inhibitor of metalloproteinases-1 (TIMP-1) in blood might be a helpful biomarker in various diseases. However, various authors report that TIMP-1 is dependent on preanalytical procedures. Our study was performed to determine how storage conditions and time to centrifugation influence TIMP-1. Materials and Methods: Twenty-six blood specimens were collected from each of 20 volunteers. Two specimens from each person were centrifuged/measured within 1 h after venipuncture and frozen at –80°C. They were thawed once or twice within 72 h. Eight specimens were stored at 20°C in daylight, 8 at 20°C covered and 8 at 4°C in daylight. Four of each of these 8 specimens were mixed once a day until centrifugation. A mixed and an unmixed specimen of each group was centrifuged/measured after 3, 6, 24 and 72 h. Results: TIMP-1 increased after freeze/thaw (p < 0.001). Mixing blood specimens more than once caused increased TIMP-1 (p < 0.001). TIMP-1 increased within 3 h of storage (p < 0.001). The increase was lower in specimens covered and refrigerated (p < 0.001). Conclusion: TIMP-1 is unstable and has to be evaluated carefully. Blood should be centrifuged directly after venipuncture. For routine application, specimen handling must be standardized and carefully followed. Research should be done on specimens handled identically.

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Plasma Metalloproteinase-12 and Tissue Inhibitor of Metalloproteinase-1 Levels and Presence, Severity, and Outcome of Coronary Artery Disease

Cited by 21 publications

References 26 publications

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes

Identifying sources and estimating glandular output of salivary TIMP‐1

Dependence of TIMP-1 Plasma Levels on Preanalytical Specimen Handling

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