Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium

Geijsen, Anne J.M.R.; Roekel, Eline H. van; Duijnhoven, Fränzel J.B. van; Achaintre, David; Bachleitner‐Hofmann, Thomas; Baierl, Andreas; Bergmann, Michael; Boehm, Jürgen; Bours, Martijn J.L.; Brenner, Hermann; Breukink, Stéphanie O.; Brezina, Stefanie; Chang‐Claude, Jenny; Herpel, Esther; Wilt, Johannes H. W. de; Gicquiau, Audrey; Gigic, Biljana; Gumpenberger, Tanja; Hansson, B.; Hoffmeister, Michael; Holowatyj, Andreana N.; Karner‐Hanusch, Judith; Keski‐Rahkonen, Pekka; Keulen, Eric T.P.; Koole, Janna L.; Leeb, Gernot; Ose, Jennifer; Schirmacher, Peter; Schneider, Martin; Schrotz‐King, Petra; Stift, Anton; Ulvik, Arve; Vogelaar, F. Jeroen; Wesselink, Evertine; Zutphen, Moniek van; Gsur, Andrea; Habermann, Nina; Kampman, Ellen; Scalbert, Augustin; Ueland, Per Magne; Ulrich, Alexis; Ulrich, Cornelia M.; Weijenberg, Matty P.; Kok, Dieuwertje E.

doi:10.1002/ijc.32666

Cited by 27 publications

(41 citation statements)

References 32 publications

(57 reference statements)

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“…In the context of cancer research decreased levels of certain LPCs were identified as potential biomarkers in colorectal cancer [ 144 , 145 , 146 ], hepatocellular carcinoma [ 147 ], ovarian cancer [ 148 , 149 ], cholangiocarcinoma [ 150 ], pancreatic and biliary tract cancer [ 151 ] as well as cervical cancer [ 152 ]. Of particular interest, LPC levels proved to correctly predict the recurrence of prostate cancer after surgery [ 153 ].…”

Section: Future Directions Of Lpc As a Biomarkermentioning

confidence: 99%

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System

Knuplez

Marsche

2020

IJMS

101

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Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context of inflammation and atherosclerosis development. While present in plasma during physiological conditions, their concentration can drastically increase in certain inflammatory states. Lysophosphatidylcholines are widely regarded as potent pro-inflammatory and deleterious mediators, but an increasing number of more recent studies show multiple beneficial properties under various pathological conditions. Many of the discrepancies in the published studies are due to the investigation of different species or mixtures of lysophatidylcholines and the use of supra-physiological concentrations in the absence of serum or other carrier proteins. Furthermore, interpretation of the results is complicated by the rapid metabolism of lysophosphatidylcholine (LPC) in cells and tissues to pro-inflammatory lysophosphatidic acid. Interestingly, most of the recent studies, in contrast to older studies, found lower LPC plasma levels associated with unfavorable disease outcomes. Being the most abundant lysophospholipid in plasma, it is of utmost importance to understand its physiological functions and shed light on the discordant literature connected to its research. LPCs should be recognized as important homeostatic mediators involved in all stages of vascular inflammation. In this review, we want to point out potential pro- and anti-inflammatory activities of lysophospholipids in the vascular system and highlight recent discoveries about the effect of lysophosphatidylcholines on immune cells at the endothelial vascular interface. We will also look at their potential clinical application as biomarkers.

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Section: Future Directions Of Lpc As a Biomarkermentioning

confidence: 99%

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System

Knuplez

Marsche

2020

IJMS

101

View full text Add to dashboard Cite

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“…A more positive loading illustrates higher consumption of a specific food group, while a more negative loading characterizes lower consumption of the food group. Only food group loadings >|0.2| were considered to contribute to the dietary pattern and visualized to improve readability missing values were imputed in line with previous studies [38][39][40]. Briefly, missing values below the LOD were imputed by half of the batch-specific LOD and values below or above the quantitative range were replaced by the lower or upper limit of quantification, respectively.…”

Section: Biomarker Analysismentioning

confidence: 99%

Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients

et al. 2021

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Purpose Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients. Methods Concentrations of 134 metabolites of the Biocrates AbsoluteIDQ p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate. Results Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations. Conclusion In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum. Clinical trial registry ClinicalTrials.gov Identifier: NCT03191110.

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“…Taurine, hypoxanthine, and two lyso-phosphatidylcholines were positively associated with colorectal cancer. In a subsequent publication we addressed differences in targeted metabolic profiles across different cancer stages and we found metabolites such as sphingomyelins, lysophosphatidylcholines, citrulline, and histidine to be associated with tumor stage [15].…”

Section: Discussionmentioning

confidence: 99%

“…Targeted metabolomics assays (Biocrates AbsoluteIDQ TM p180Kit) were performed on pre-surgery collected plasma samples from n = 440 newly diagnosed stage II/III colorectal cancer patients recruited within four prospective cohort studies from the international consortium "Metabolomic profiles throughout the continuum of colorectal cancer" (MetaboCCC) [11,15]. Patients with a recurrence of primary colorectal cancer at least three months after curative surgery were defined as event.…”

Section: Methodsmentioning

confidence: 99%

Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium

et al. 2021

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The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort; false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15%) had a recurrence after a median follow-up time of 20 months. We identified 13 metabolites that were nominally associated with a reduced risk of recurrence. None of the associations were statistically significant after controlling for multiple testing. Pathway topology analyses did not reveal statistically significant associations between recurrence and alterations in metabolic pathways (e.g., sphingolipid metabolism p = 0.04; pFDR = 1.00). To conclude, we did not observe statistically significant associations between metabolites and CRC recurrence using a well-established metabolomics assay. The observed results require follow-up in larger studies.

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Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium

Abstract: Plasma metabolites and colorectal cancer stage

Cited by 27 publications

References 32 publications

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System

An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System

Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients

Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium

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