Plasma metabolic profiling reveals that chromium yeast alleviates the negative effects of heat stress in mid-lactation dairy cows

Wo, Yeqianli; Ma, Fengtao; Shan, Qiang; Gao, Duo; Jin, Yinghua; Sun, Pu

doi:10.1016/j.aninu.2023.01.012

Cited by 2 publications

(1 citation statement)

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“…Acting as a component of the glucose tolerance factor, Cr is important for enhancing the effect of insulin (Siddiqui et al 2014 ). Therefore, given its relevance in improving carbohydrate and lipid metabolism, it is commonly used in research addressing treatments for diabetes and obesity in humans and animal models (Vincent 2001 ; Tian et al 2013 ; Maret 2019 ; Wo et al 2023 ). Recently, dietary Cr supplementation is becoming widely used in livestock husbandry with the aim of improving growth performance, production capacity, immune function, and antioxidative ability (Zheng et al 2016 ; Sahin et al 2017 ; Bin-Jumah et al 2020 ; Bompadre et al 2020 ; Piray and Foroutanifar 2021 ).…”

Section: Chromium-mediated Neuroprotectionmentioning

confidence: 99%

Insulin-like growth factor 1 in heat stress-induced neuroinflammation: novel perspective about the neuroprotective role of chromium

et al. 2023

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Heat stress (HS) can cause a series of stress responses, resulting in numerous negative effects on the body, such as the diminished food intake, carcass quality and reproductive capacity. In addition to the negative effects on the peripheral system, HS leads to central nervous system (CNS) disorders given its toll on neuroinflammation. This neuroinflammatory process is mainly mediated by microglia and astrocytes, which are involved in the activation of glial cells and the secretion of cytokines. While the regulation of inflammatory signaling has a close relationship with the expression of heat shock protein 70 (Hsp70), HS-induced neuroinflammation is closely related to the activation of the TLR4/NF-κB pathway. Moreover, oxidative stress and endoplasmic reticulum (ER) stress are key players in the development of neuroinflammation. Chromium (Cr) has been widely shown to have neuroprotective effects in both humans and animals, despite the lack of mechanistic evidence. Evidence has shown that Cr supplementation can increase the levels of insulin-like growth factor 1 (IGF-1), a major neurotrophic factor with anti-inflammatory and antioxidant effects. This review highlights recent advances in the attenuating effects and potential mechanisms of Cr-mediated IGF-1 actions on HS-induced neuroinflammation, providing presently existing evidence supporting the neuroprotective role of Cr.

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