1993
DOI: 10.1016/0009-9120(93)90084-j
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Plasma membranes from human liver contain an enzyme activity that removes the membrane anchor of alkaline phosphatase and converts it to a plasma-like form

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Cited by 3 publications
(4 citation statements)
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“…Circulating osteopontin and alkaline phosphatase (ALP) are sensitive osteogenic markers that are of diagnostic value [30, 31]. Figure 3a shows that plasma osteopontin levels and ALP activities were significantly higher in both 1- and 4-month TO2 hamsters, suggesting ongoing abnormal osteogenic events.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Circulating osteopontin and alkaline phosphatase (ALP) are sensitive osteogenic markers that are of diagnostic value [30, 31]. Figure 3a shows that plasma osteopontin levels and ALP activities were significantly higher in both 1- and 4-month TO2 hamsters, suggesting ongoing abnormal osteogenic events.…”
Section: Resultsmentioning
confidence: 99%
“…A commonly used osteogenic marker is the phosphate-splitting enzyme alkaline phosphatase (ALP), which is induced during the early stage of osteogenesis [30, 31]. Although aberrant circulating levels of ALP can be associated with a wide range of disease conditions [44, 45], the abnormally high levels of ALP activities in the plasma and heart tissue of TO2 hamsters were detected in the absence of abnormal liver ALP activity.…”
Section: Discussionmentioning
confidence: 99%
“…Bone-specific alkaline phosphatase Alkaline phosphatase (ALP) is a ubiquitous, membrane-bound enzyme attached to glycosylphosphatidylinositol moieties located on the outer cell surface [36]. The serum pool of ALP consists of several dimeric isoforms, which originate from various tissues: liver, bone, intestine, spleen, kidney, and placenta.…”
Section: Enzyme-based Markers Of Bone Turnovermentioning
confidence: 99%
“…The CTGF-induced VSMC calcification is associated with the induction of bone markers, including ALP, OC and OPG, demonstrating the transdifferentiation of VSMCs into osteoblast-like cells. It has been demonstrated in previous studies that ALP genes are early markers of the transdifferentiation of VSMCs into phenotypically osteoblast-like cells, and that OC proteins are indicators of the late stage of transdifferentiation (42,43). OPG is a key regulator of osteoclastogenesis and may protect cells from arterial calcification (44).…”
Section: Discussionmentioning
confidence: 99%