Plasma medicine: Opportunities for nanotechnology in a digital age

Liu, Dawei; Szili, Endre J.; Ostrikov, Kostya Ken

doi:10.1002/ppap.202000097

Cited by 35 publications

(22 citation statements)

References 59 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies DOI: http://dx.doi.org/10.5772/intechopen.95494 benefits for the development of effective therapies improved selective effects and high safety for modern oncology. In this section of the chapter, we focus on the created opportunities for linking plasma technologies and nanocarriers in lung cancer treatment [8][9][10][11][12].…”

Section: Gas Plasma In Conjunction With Nanoparticle For Lung Cancer Treatmentmentioning

confidence: 99%

“…It is time to consider synergies and the simultaneous combination of plasma-nanoparticles and their associated benefits for the development of effective therapies that improved selective efficacy and high safety for modern medicine. Here, a detailed overview of the advantages and limitations of nanomedicine and plasma medicine as novel technologies are presented and then we enumerate some of the main possibilities of synergy between nanotechnology and plasma technology for lung cancer treatment [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies

Rasouli¹,

Fallah²,

Ostrikov³

2021

Lung Cancer - Modern Multidisciplinary Management

View full text Add to dashboard Cite

Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high potential through physical and chemical effects for cancer treatment. Recently, CAP, plasma activated liquid (PAL), and nanomaterial have been significant advances in oncotherapy. Reactive oxygen-nitrogen species (RONS), electrical field, and other agents generated by CAP interact with cells and induce selective responses between the malignant and normal cells. Nanomedicine enhances therapeutic effectiveness and decreases the side effects of traditional treatments due to their target delivery and dispersion in tumor tissue. There are various nanocarriers (NCs) which based on their properties can be used for the delivery of different agents. The combination of gas plasma and nanomaterials technologies is a new multimodal treatment in cancer treatment, therefore, is expected that the conjunction of these technologies addresses many of the oncology challenges. This chapter provides a framework for current research of NC and gas plasma therapies for lung cancer. Herein, we focus on the application of gas plasmas and nanotechnology to drug and gene delivery and highlight several outcomes of its. The types and features of the mentioned therapeutics strategy as novel classes for treating lung cancer individually and synergistic were examined.

show abstract

Section: Gas Plasma In Conjunction With Nanoparticle For Lung Cancer Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies

Rasouli¹,

Fallah²,

Ostrikov³

2021

Lung Cancer - Modern Multidisciplinary Management

View full text Add to dashboard Cite

show abstract

“…The high concentration of ROS oxidizes the lipids and increases the penetration abilities of reactive species through the oxidized lipid bilayer. [ 28 ] The transmembrane protein channels have the possibility to transfer ROS into cells. [ 29 ]…”

Section: Introductionmentioning

confidence: 99%

Enhanced transmembrane transport of reactive oxygen species by electroporation effect of plasma

Yang

Liu

2021

Plasma Processes & Polymers

Self Cite

View full text Add to dashboard Cite

Recently, plasma has been proposed as a new efficient tool for various biological and medical applications. The function of plasma is mainly realized through two aspects: Electric field and reactive species. However, because the interactions between plasma and cells are quite complicated, the synergistic effect of electric field and reactive species has not been studied in depth. In this paper, the synergetic effects of electric field and transportation of reactive species on cells are investigated by a two‐dimensional finite element model. The exposure of cells to plasma results in the sufficiently high transmembrane voltage (1 V) and electroporation. When the electric field of plasma is less than 104 V/cm, the radius of nanopores generated by plasma increases with the electric field. The further increase of electric field to 105 V/cm does not cause a significant increase of nanopore radius, whereas the pore density increases by five times. The increase of discharge frequency significantly decreases the time needed to generate stable nanopores. The nanopores enhance the diffusion of H2O2 generated by plasma through the cell membrane significantly. Compared with the reality that H2O2 does not freely diffuse across cell membranes, the “generation and enhanced transportation” effect will further expand the application range of plasma medicine.

show abstract

“…In the last few decades and years, the use of plasmas as an enabling key technology has allowed for the development of novel approaches and methods in quite different fields of applications. For instance, novel plasma-based healthcare solutions were recently established-which is essential progress, especially with respect to the persisting COVID-19 pandemic [7]. The application of plasmas has also become a powerful tool in dermatology [8] or even minimal-invasive endoscopic cancer therapy [9].…”

mentioning

confidence: 99%