Plasma MCP-1 levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment

Edberg, David; Hoppensteadt, Debra; Fareed, Jawed; Sinacore, James; Halaris, Angelos

doi:10.1016/j.jpsychires.2020.06.010

Cited by 13 publications

(16 citation statements)

References 47 publications

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“…Patients with depression are usually associated with increased secretion of cytokine IL-1β and decreased IL-10 and a significant increase in the expressions of proinflammatory genes COX-2 and MCP-1 [29][30][31]. Consistently, our work demonstrated that CUMS rat hippocampal tissue had greatly increased IL-1β, COX-2, and MCP-1, while IL-10 was significantly decreased.…”

Section: Discussionsupporting

confidence: 80%

Red Raspberry Extract Decreases Depression-Like Behavior in Rats by Modulating Neuroinflammation and Oxidative Stress

Chen

Yang²,

et al. 2022

BioMed Research International

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Objective. Red raspberry serves as a proven natural product to produce anti-inflammatory, antioxidant, and anticancer functions, but limited findings are available on its effects on depression. This study, by using a chronic unpredictable mild stress- (CUMS-) induced depression model, thus investigated the effects and underlying mechanism of red raspberry extract (RRE) on depressive behavior, inflammation, and oxidative stress. Methods. Different treatments were given after random grouping of Sprague-Dawley rats, including no intervention (control), CUMS induction, and CUMS+different concentrations of RRE, and subsequently, depression-like behavior tests were performed. HE staining was designed to observe the pathological damage of the hippocampal tissue in rats. The levels of oxidative stress, endocrine hormones, and inflammatory factors were determined by biochemical assay and ELISA, and gene expression (mRNA and protein) in the hippocampal tissue by qRT-PCR and Western blot. Results. On completion of CUMS treatment, the rats showed severe depression-like behavior, with obvious hippocampal tissue damage, oxidative inflammatory response, and endocrine imbalance. Importantly, RRE treatment significantly improved such depression-like behavior and attenuated histopathological damage in CUMS rats when reducing inflammation and oxidative stress and endocrine imbalance with upregulation of glutathione (GSH), superoxide dismutase (SOD), and interleukin- (IL-) 10 and downregulation of adrenocorticotropic hormone (ACTH), corticosterone (CORT), malondialdehyde (MDA), IL-1β, cyclooxygenase- (COX-) 2, and human macrophage chemoattractant protein- (MCP-) 1. In addition, for CUMS rats, RRE was a contributor to increasingly expressed brain-derived neurotrophic factor (BDNF), neurotrophic tyrosine receptor kinase 2 (TrkB), and p-mTOR but inhibited p-GSK-3β expression in the hippocampal tissue. All the above antidepressant effects of RRE were concentration-dependent. Conclusion. By regulating neuroinflammation, oxidative stress response, endocrine level, and BDNF/TrkB level, RRE showed potential efficacy in alleviating depression-like behavior and histopathological damage of hippocampal tissue in CUMS rats by regulating the GSK3β and mTOR signaling pathways.

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Section: Discussionsupporting

confidence: 80%

Red Raspberry Extract Decreases Depression-Like Behavior in Rats by Modulating Neuroinflammation and Oxidative Stress

Chen

Yang²,

et al. 2022

BioMed Research International

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“…This hypothesis is supported by studies in which dysthymic as well as MDD patients treated with escitalopram [ 78 , 79 ] or venlafaxine [ 54 ], despite initially elevated levels of CCL2 compared to healthy individuals, resulting in effective antidepressant response, but did not affect the CCL2 level. A similar observation was described in patients diagnosed with BD treated with the combination of escitalopram and celecoxib, where treatment responders had higher serum levels of CCL2 than those with more refractory depression [ 67 ]. The above reports may be supplemented by the results of post-mortem studies in patients treated with antidepressants, for whom the non-inflammatory microglia phenotype was suggested and these cells were characterized by increased expression of homeostatic markers [ 80 ].…”

Section: Ccl2-ccr2 Axis In Antidepressant Therapy—experimental Studies and Clinical Trialssupporting

confidence: 70%

“…However, there are also data indicating the CCL2 decrease in the serum/plasma of patients with depressive disorders [63][64][65] or an unchanged level of this chemokine compared to healthy subjects in the serum of patients with BD [66,67]. Interestingly, lower plasma levels of CCL2 in patients with MDD correlated with the occurrence of suicidal patients, while the level of CCL2 did not differ between patients with nonsuicidal MDD and healthy patients [63].…”

Section: The Role Of the Ccl2-ccr2 Signaling In Affective Disorders-experimental And Clinical Studiesmentioning

confidence: 99%

Targeting the CCL2-CCR2 axis in depressive disorders

Curzytek

Leśkiewicz

2021

Pharmacol. Rep

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Since affective disorders are considered to be underlain by the immune system malfunction, an important role in their pathophysiology is assigned to the proinflammatory mediators. Recently, chemokines, the group of chemotactic cytokines, have become a focus for basic and clinical scientists in the context of the development and treatment of brain diseases. Among them, chemokine CCL2 and its main receptor CCR2 have become candidate mediators of abnormal brain-immune system dialogue in depression. Besides the chemotactic activity, the CCL2-CCR2 axis is involved in various neurobiological processes, neurogenesis, neurotransmission, neuroinflammation, neurodegeneration, as well as neuroregeneration. Given the range of immunomodulatory possibilities that the CCL2-CCR2 pair can exert on the nervous system, its proinflammatory properties were initially thought to be a major contributor to the development of depressive disorders. However, further research suggests that the malfunctions of the nervous system are rather associated with impaired homeostatic properties manifested by the CCL2-CCR2 dyad dysfunctions. This review aims to present literature data on the action of the CCL2-CCR2 axis in the central nervous system under physiological and pathological conditions, as well as the contribution of this ligand-receptor system to the processes underlying affective disorders. Additionally, this article draws attention to the importance of the CCL2-CRR2 pathway as a potential pharmacological target with antidepressant potential.

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“…Neuroinflammation plays an important role in the pathophysiology of psychiatric disorders and alteration in the chemokine levels in MDD patients (Edberg et al, 2020). Chemokine MCP-1 performs functions in leukocyte trafficking, fibrosis, tissue remodeling, and angiogenesis during the neuroinflammation process (Lukacs, 2001; Schall and Bacon, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…But a recent study by Edberg et al revealed that MCP-1 is associated with both pro-and anti-inflammatory analytes in depressive subjects. During cyclooxygenase-2 (COX-2) inhibition treatment, alteration in MCP-1 levels influenced by its surrounding inflammatory milieu (Edberg et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Monocyte chemoattractant protein-1 levels are associated with major depressive disorder

Proma

Daria

Islam

et al. 2020

Preprint

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Major depressive disorder (MDD) is a distressing condition characterized by persistent low mood, loss of interest in daily activities. Many biological, psycho-social, and genetic factors are thought to be involved with depression. The present study aimed to investigate the serum levels of monocyte chemoattractant protein-1 (MCP-1) in MDD patients to explore its role in the development of depression. This case-control study recruited 114 MDD patients and 106 healthy controls (HCs) matched by age and gender. A specialized psychiatrist diagnosed the cases and evaluated the controls based on the diagnostic and statistical manual for mental disorders, 5th edition. The serum MCP-1 levels were quantified by commercially available enzyme-linked immune sorbent assay kits. The Hamilton depression rating scale (Ham-D) was applied to measure the severity of depression. We observed the decreased levels of serum MCP-1 in MDD patients compared to HCs. A significant negative correlation was obtained between serum MCP-1 levels and Ham-D scores. Also, female MDD patients with higher Ham-D scores exhibited lower serum MCP-1 levels. The receiver operating characteristic analysis demonstrated the good diagnostic value of MCP-1 with the area under the curve at 0.837. The depression-related alteration of serum MCP-1 may be more complicated than the current assumption and depends on the characteristics of the individual patients. Our study suggests that the serum MCP-1 levels might be involved in the pathophysiology and mechanism of MDD. The present findings, along with the diagnostic evaluation, might be used to assess the depression risk.

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Plasma MCP-1 levels in bipolar depression during cyclooxygenase-2 inhibitor combination treatment

Cited by 13 publications

References 47 publications

Red Raspberry Extract Decreases Depression-Like Behavior in Rats by Modulating Neuroinflammation and Oxidative Stress

Red Raspberry Extract Decreases Depression-Like Behavior in Rats by Modulating Neuroinflammation and Oxidative Stress

Targeting the CCL2-CCR2 axis in depressive disorders

Monocyte chemoattractant protein-1 levels are associated with major depressive disorder

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