Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients

Giron, Leila B.; Dweep, Harsh; Yin, Xiangfan; Wang, Han; Damra, Mohammad; Goldman, Aaron R.; Gorman, Nicole; Palmer, Clovis S.; Tang, Hsin‐Yao; Shaikh, Maliha; Forsyth, Christopher B.; Balk, R.A.; Zilberstein, Netanel F; Q, Liu; Kossenkov, Andrew V.; Keshavarzian, Ali; Landay, Alan; Abdel‐Mohsen, Mohamed

doi:10.1101/2020.11.13.20231209

Cited by 48 publications

(54 citation statements)

References 143 publications

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“…Measurement of LPS-binding protein, a marker of inflammation also revealed a significant increase among severe COVID-19 cases than milder cases. These findings support the association between severe COVID-19 and gut permeability and microbial translocation ( 72 ).…”

Section: Possible Role Of Gut Dysbiosis In Pathophysiology Of Covid-1supporting

confidence: 87%

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Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?

et al. 2021

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Section: Possible Role Of Gut Dysbiosis In Pathophysiology Of Covid-1supporting

confidence: 87%

“…The study reports significantly decreased levels of citrulline, an amino acid that is an established marker of gut and enterocyte function. Also, the levels of succinic acid, a well-known marker of gut microbial dysbiosis were observed to be increasing during severe COVID-19 ( 72 ).…”

Section: Impact Of Sars-cov-2 Infection On Gut Microbiotamentioning

confidence: 99%

Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?

et al. 2021

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“…These perturbations have been shown to be associated with more severe outcomes during acute infection [36,37]. Second, even in the absence of systemic inflammation, local tissue inflammation or ongoing immune cell infiltration into the tissues could result in tissue injury and remodeling, which could drive PASC through processes like microbial translocation in the gut [38] or tissue fibrosis in the heart or lungs. Organ-specific studies such as cardiac MRI suggest persistent inflammation for up to 3 months after acute illness [16,17].…”

Section: Discussionmentioning

confidence: 99%

Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19

Peluso

Kelly

et al. 2021

Preprint

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BACKGROUND: As the coronavirus disease 2019 (COVID-19) pandemic continues and millions remain vulnerable to infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), attention has turned to characterizing post-acute sequelae of SARS-CoV-2 infection (PASC). METHODS: From April 21 to December 31, 2020, we assembled a cohort of consecutive volunteers who a) had documented history of SARS-CoV-2 RNA-positivity; b) were ≥ 2 weeks past onset of COVID-19 symptoms or, if asymptomatic, first test for SARS-CoV-2; and c) were able to travel to our site in San Francisco. Participants learned about the study by being identified on medical center-based registries and being notified or by responding to advertisements. At 4-month intervals, we asked participants about physical symptoms that were new or worse compared to the period prior to COVID-19, mental health symptoms and quality of life. We described 4 time periods: 1) acute illness (0-3 weeks), 2) early recovery (3-10 weeks), 3) late recovery 1 (12-20 weeks), and 4) late recovery 2 (28-36 weeks). Blood and oral specimens were collected at each visit. RESULTS: We have, to date, enrolled 179 adults. During acute SARS-CoV-2 infection, 10 had been asymptomatic, 125 symptomatic but not hospitalized, and 44 symptomatic and hospitalized. In the acute phase, the most common symptoms were fatigue, fever, myalgia, cough and anosmia/dysgeusia. During the post-acute phase, fatigue, shortness of breath, concentration problems, headaches, trouble sleeping and anosmia/dysgeusia were the most commonly reported symptoms, but a variety of others were endorsed by at least some participants. Some experienced symptoms of depression, anxiety, and post-traumatic stress, as well as difficulties with ambulation and performance of usual activities. The median visual analogue scale value rating of general health was lower at 4 and 8 months (80, interquartile range [IQR]: 70-90; and 80, IQR 75-90) compared to prior to COVID-19 (85; IQR 75-90). Biospecimens were collected at nearly 600 participant-visits. CONCLUSION: Among a cohort of participants enrolled in the post-acute phase of SARS-CoV-2 infection, we found many with persistent physical symptoms through 8 months following onset of COVID-19 with an impact on self-rated overall health. The presence of participants with and without symptoms and ample biological specimens will facilitate study of PASC pathogenesis. Similar evaluations in a population-representative sample will be needed to estimate the population-level prevalence of PASC.

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“…The gut microbiota has a critical role in pulmonary immunity and the host’s defense against viral respiratory infections; current evidence points to SARS-CoV-2 infection altering the gut barrier, leading to the systemic spread of bacteria, endotoxins, and microbial metabolites 9 . It has been suggested that a cycle between SARS-CoV2 infection, systemic inflammation, disrupted intestinal barrier integrity, and microbial translocation contributes to COVID-19 severity 10 .…”

Section: Introductionmentioning

confidence: 99%

Functional profiling of COVID-19 respiratory tract microbiomes

Haiminen

Utro

Seabolt

et al. 2021

Sci Rep

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In response to the ongoing global pandemic, characterizing the molecular-level host interactions of the new coronavirus SARS-CoV-2 responsible for COVID-19 has been at the center of unprecedented scientific focus. However, when the virus enters the body it also interacts with the micro-organisms already inhabiting the host. Understanding the virus-host-microbiome interactions can yield additional insights into the biological processes perturbed by viral invasion. Alterations in the gut microbiome species and metabolites have been noted during respiratory viral infections, possibly impacting the lungs via gut-lung microbiome crosstalk. To better characterize microbial functions in the lower respiratory tract during COVID-19 infection, we carry out a functional analysis of previously published metatranscriptome sequencing data of bronchoalveolar lavage fluid from eight COVID-19 cases, twenty-five community-acquired pneumonia patients, and twenty healthy controls. The functional profiles resulting from comparing the sequences against annotated microbial protein domains clearly separate the cohorts. By examining the associated metabolic pathways, distinguishing functional signatures in COVID-19 respiratory tract microbiomes are identified, including decreased potential for lipid metabolism and glycan biosynthesis and metabolism pathways, and increased potential for carbohydrate metabolism pathways. The results include overlap between previous studies on COVID-19 microbiomes, including decrease in the glycosaminoglycan degradation pathway and increase in carbohydrate metabolism. The results also suggest novel connections to consider, possibly specific to the lower respiratory tract microbiome, calling for further research on microbial functions and host-microbiome interactions during SARS-CoV-2 infection.

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Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients

Cited by 48 publications

References 143 publications

Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?

Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?

Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19

Functional profiling of COVID-19 respiratory tract microbiomes

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