Plasma-Lyte 148 vs. Hartmann’s solution for cardiopulmonary bypass pump prime: a prospective double-blind randomized trial

Abstract

During CPB, PL and HS did not cause a significant metabolic acidosis. There was hyperacetatemia and hypergluconatemia with PL and hyperchloremia and hyperlactatemia with HS. These physiochemical effects appear clinically innocuous.

Contemporary Australian priming constituents for adult perfusion centres: a survey

“…Since this survey was conducted, Weinberg et al 8 have published an investigation on the incidence of either a Plasma-Lyte or Hartmann's prime solution in causing metabolic acidosis on bypass. The conclusion to this study was that neither solution produced a metabolic acidosis at the bypass time of 60 minutes.…”

“…As noted, metabolic acidosis has not been shown at the end of bypass with either Plasma-Lyte or Hartmann's solution in the modern context. 8 Mannitol is reported to be beneficial for maintaining osmotic pressure, renal function and fluid balance. 1,6 A total of 19 (30%) units add mannitol with the intent to achieve this benefit and more.…”

The problem of using standardised base excess as a measure of metabolic acidosis

“…It was gratifying to read Weinberg and colleagues' study comparing the effects of two crystalloid solutions on acid-base balance as there is insufficient evidence of the effects of priming solutions used for cardiopulmonary bypass (CPB) on the outcome from cardiac surgery. 1 We have noted the important contribution of the effects of disturbances in strong ion difference caused by priming solutions on acid-base balance. 2 Indeed, we have noted the important effects of changing of the prime from Ringer's to Hartmann's solutions.…”

Hypocalcaemia induced by priming the cardiopulmonary bypass circuit with Plasma-Lyte 148

“…During our literature search for the review, we identified Weinburg and colleagues' paper comparing Plasma-Lyte 148 and Hartmann's solutions for priming cardiopulmonary bypass (CPB) circuits. 1 Although the primary direction of their randomised controlled trial was to examine the effect on acid-base balance, it reports some very important information as to the effects of priming solutions on blood calcium levels.…”