Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study

Delcourt, Cécile; Carrière, Isabelle; Delage, Michel; Barberger‐Gateau, Pascale; Schalch, Wolfgang

doi:10.1167/iovs.05-1235

Cited by 230 publications

(145 citation statements)

References 40 publications

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“…There is currently not Recommended Dietary Allowance RDA or Recommended Daily Intake RDI for lutein and zeaxanthin but some experts say you should ingest at least 4-6 milligrams mg of these carotenoids per day for beneficial effects 20,21 . Thus, in this study we managed to obtain 50.5 mg/kg in olive oil enriched from spinach 24 hour; 75:25 ratio in addition to the recommended daily amount of virgin olive oil of 23 grames 11 .…”

Section: Resultsmentioning

confidence: 99%

Virgin Olive Oil Enriched with Lutein-Zeaxanthin from <i>Spinacia oleracea</i>

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Virgin Olive Oil Enriched with Lutein-Zeaxanthin from <i>Spinacia oleracea</i>

et al. 2017

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“…Xanthophylls act as antioxidants and shield ocular structures from blue light, which causes retinal injury leading to AMD ( 6 , 7 ). Previously, numerous studies showed that lutein has the potential to delay the development of AMD (8)(9)(10)(11)(12)(13). Lutein and zeaxanthin have been described as protecting photoreceptors from apoptosis induced by oxidative stress in vitro ( 8 ).…”

mentioning

confidence: 99%

“…Johnson et al demonstrated that consumption of spinach and corn, which contain lutein, in the daily diet for 15 wk raised the serum lutein concentration ( 12 ). In addition, Delcourt et al showed that high plasma lutein and zeaxanthin concentrations were associated with a reduced risk of AMD ( 13 ). Continuous ingestion of vegetables rich in lutein might contribute to an increased serum lutein concentration, thereby lowering the risk of AMD.…”

mentioning

confidence: 99%

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

Takeda

Masuda

Usuda

et al. 2009

J Nutr Sci Vitaminol

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Summary To clarify the effects of different physical forms of oil on postprandial serum lutein/zeaxanthin and ␤ -carotene concentrations, we performed a vegetable meal loading test. Eighteen healthy subjects participated in the test, which consisted of broccoli as a control (CON) meal, broccoli with oil (OIL), and broccoli with mayonnaise (MS), consumed in random order. After collection of fasting blood samples, subjects consumed one of the three test meals. Fasting and postprandial changes in serum carotenoids were assessed 2, 4, and 6 h after ingestion of each test meal. Serum lutein/zeaxanthin and ␤ -carotene concentrations were measured. Although no significant change was noted after the CON meal, the serum lutein/zeaxanthin concentration was higher at 4 h after consumption of the OIL meal, and at 2, 4 and 6 h after consumption of the MS meal, as compared with the fasting state. Serum ␤ -carotene concentrations did not change after ingestion of either the CON or the OIL meal but were elevated 2, 4, and 6 h after MS ingestion as compared with the fasting state. The incremental areas under the curves (IAUCs) of serum lutein/zeaxanthin and ␤ -carotene concentrations were higher after the MS meal than after the CON meal. IAUCs after the OIL meal exhibited no statistically significant differences from the CON and MS meals. We suggest that mayonnaise contributes to increase serum lutein/zeaxanthin and ␤ -carotene concentrations when consumed with vegetables rich in these carotenoids.

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“…There is a small study, which suggests Lutein supplements can improve vision in the short term, 34 adding to the concern surrounding b-carotene in the AREDS preparation, this has lead to significant confusion.…”

Section: Macular Pigmentsmentioning

confidence: 99%

Looking beyond Lucentis on the management of macular degeneration

Fletcher

Chong

2008

Eye

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Purpose Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. In the past decade, AMD research has improved our understanding of the pathogenesis of the condition. There is no doubt that anti-VEGF therapies will play a major role in the reduction of blindness, but it needs close monitoring and frequent treatments. In this review we summarise the key pathophysiology of the condition and some of the new treatment strategies under development. Methods Literature review. Results Oxidative stress, inflammation, hypoxia, and angiogenesis are key pathophysiological processes in AMD, this diversity has provided a variety of possible areas amenable to modification to enhance the treatment options for AMD.

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Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study

Abstract: These results are strongly suggestive of a protective role of the xanthophylls, in particular zeaxanthin, for the protection against ARM and cataract.

Cited by 230 publications

References 40 publications

Virgin Olive Oil Enriched with Lutein-Zeaxanthin from <i>Spinacia oleracea</i>

Virgin Olive Oil Enriched with Lutein-Zeaxanthin from <i>Spinacia oleracea</i>

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

Looking beyond Lucentis on the management of macular degeneration

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