Plasma long noncoding RNA IL‐7R as a prognostic biomarker for clinical outcomes in patients with acute respiratory distress syndrome

Wan, Bing; Xu, Weizong; Xu, Wei‐Nan; Zhan, Ping; Wu, Guannan; Jin, Jiajia; Xi, Guangmin; Yin, Jie; Zhang, Hao; Chen, Yi‐Kun; Miao, Yingying; Wang, Xiaoxia; Xu, Yingkun; Lv, Tangfeng; Song, Yong

doi:10.1111/crj.12717

Cited by 14 publications

(9 citation statements)

References 26 publications

(33 reference statements)

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“…Web servers can assist in quickly assessing experimentally determined or predictive RNA-RNA interactions [204] or even RNA-protein interactions [205,206]. Depending on the subcellular or extracellular compartmental localization of a lncRNA, this patterning will elude to the regulatory role of the gene, as well as how a lncRNA might execute its function [207][208][209]. Some LncRNAs that are localized to the nucleus or chromatin have been experimentally shown to function in cis to regulate the transcriptional expression of a neighboring gene, or in trans to regulate the transcriptional regulation of a subclass of genes through the interactions between heterogeneous nuclear ribonucleoproteins (hnRNPs) [42,54,60,210].…”

Section: Subcellular Localization and Binding Partnersmentioning

confidence: 99%

The how and why of lncRNA function: An innate immune perspective

Robinson

Covarrubias

2020

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

226

192

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Section: Subcellular Localization and Binding Partnersmentioning

confidence: 99%

The how and why of lncRNA function: An innate immune perspective

Robinson

Covarrubias

2020

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanism

226

192

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“…Plasma lnc-IL7R levels are reduced in patients with ARDS. 24 COPD is also a systemic inflammatory disease that induces extrapulmonary effects. 2 Our results indicate that lnc-IL7R levels were significantly reduced in COPD PBMCs and correlated with lung function ( Figure 1A).…”

Section: Low Plasma Lnc-il7r Levels Are Associated With Copd Exacermentioning

confidence: 99%

“…22 Clinically, plasma levels of lnc-IL7R were associated with illness severity and mortality in patients with acute respiratory distress syndrome (ARDS). 24 In addition, lnc-IL7R may promote cell proliferation and cell-cycle progression and inhibit apoptosis. 25 Similarly, it is involved in chemoresistance in oral squamous cell carcinoma (OSCC) 26 and correlated with poor clinical outcomes in cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Impaired lnc‐IL7R modulatory mechanism of Toll‐like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease

Feng

Chuang

et al. 2020

FASEB j.

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Patients with chronic obstructive pulmonary disease (COPD) are susceptible to bacterial infections, which worsen lung inflammation and contribute to lung function decline and acute exacerbation. Long noncoding (lnc) RNAs are emerging regulators of inflammation with unknown clinical relevance. Herein, we report that levels of the Toll‐like receptor (TLR)‐related lnc interleukin (IL) 7 receptor (IL7R) were significantly reduced in peripheral blood mononuclear cells from patients with COPD compared with those from normal controls, and the levels were correlated with pulmonary function. Moreover lnc‐IL7R levels were reduced in lavaged alveolar macrophages and primary human small airway epithelial cells (HSAEpCs) from patients with COPD. Lnc‐IL7R knockdown in primary human macrophages, HSAEpCs, and human pulmonary microvascular endothelial cells (HPMECs) significantly augmented the induction of proinflammatory mediators after TLR2/4 activation. By contrast, lnc‐IL7R overexpression attenuated inflammation after TLR2/4 activation. Similar results with lnc‐IL7R‐mediated inflammation were observed in COPD HSAEpCs. Mechanistically, lnc‐IL7R mediated a repressive chromatin state of the proinflammatory gene promoter as a result of decreased acetylation (H3K9ac) and increased methylation (H3K9me3 and H3K27me3). Plasma lnc‐IL7R levels were reduced in patients with COPD who experienced more acute exacerbation in the previous year. Notably, patients with lower lnc‐IL7R levels in the subsequent year had increased exacerbation risk. Low lnc‐IL7R expression in COPD may augment TLR2/4‐mediated inflammation and be associated with acute exacerbation.

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“…21 The plasma levels of lncRNA IL-7R were correlated with WBC (P=0.0064) in patients with acute respiratory distress syndrome. 22 The lncRNA CoroMarker mainly exists in the extracellular vesicles, probably from monocytes, and is stable in plasma. 23 These findings were consistent with the current results that serum NONHSAT053785 expression was correlated with peripheral blood cells.…”

Section: Discussionmentioning

confidence: 99%

<p>A Novel lncRNA NONHSAT053785 Acts as an Independent Risk Factor for Intrahepatic Metastasis of Hepatocellular Carcinoma</p>

Chen

et al. 2020

OTT

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Long noncoding RNAs (lncRNAs) in body fluids have been considered as promising novel biomarkers for tumor-related diseases. The present study aimed to investigate the expression level of lncRNA NONHSAT053785 in serum and its correlation with clinical characteristics of hepatocellular carcinoma (HCC) patients. Methods: The droplet digital PCR (ddPCR) was used to measure the serum levels of NONHSAT053785 in 112 HCC patients, 96 chronic hepatitis B (CHB) patients, and 99 healthy controls (HC). The correlation between NONHSAT053785 and clinical characteristics was analyzed by chi-square test and Spearman correlation test. The risk factors of intrahepatic metastasis (IM) were detected by univariate and multivariate analyses. Furthermore, the diagnostic value of NONHSAT053785 in HCC and its predictive ability in IM were evaluated by the receiver operating characteristic (ROC) curves. Results: The level of NONHSAT053785 was significantly increased in the serum of HCC patients and was higher in HCC patients with IM as compared to those without. Additionally, the expression level of NONHSAT053785 was significantly related to IM, Child-Pugh classification, and peripheral blood indicators such as liver metabolic enzymes and positively correlated to IM, Barcelona Clinic Liver Cancer (BCLC) staging, and some peripheral blood indicators. Furthermore, the serum NONHSAT053785 was indicated as an independent predictor for IM in the elderly, non-smoking, drinking, and tumor size ≥5 cm subjects. The area under the ROC curve (AUC) was 0.801 (P <0.0001) for diagnosis of HCC and 0.678 (P =0.0015) for predicting IM. Conclusion: The increase in serum NONHSAT053785 levels was related to an increased risk of IM, and hence, may serve as a novel biomarker for the diagnosis of HCC and the prediction of IM.

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Plasma long noncoding RNA IL‐7R as a prognostic biomarker for clinical outcomes in patients with acute respiratory distress syndrome

Abstract: The study was registered with the Chinese Clinical Trial Registry (ChiCTR-DOD-16008657).

Cited by 14 publications

References 26 publications

The how and why of lncRNA function: An innate immune perspective

The how and why of lncRNA function: An innate immune perspective

Impaired lnc‐IL7R modulatory mechanism of Toll‐like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease

<p>A Novel lncRNA NONHSAT053785 Acts as an Independent Risk Factor for Intrahepatic Metastasis of Hepatocellular Carcinoma</p>

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