Plasma lncRNA LIPCAR Expression Levels Associated with Neurological Impairment and Stroke Subtypes in Patients with Acute Cerebral Infarction: A Prospective Observational Study with a Control Group

Liu, Z; Lin, Wei; Feng, Yuan; Huang, Congli; Yi, Yan; Guo, Weiyan; Zhang, Huan; Lei, Zhen; Lu, Qingli; Liu, Pei; Lin, Xuemei; Wu, Songdi

doi:10.1007/s40120-023-00482-9

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…The relevance of LIPCAR as a biomarker is confirmed by more recent studies conducted on patients with coronary artery disease [99], ST-segment elevation myocardial infarction [100], cardiovascular disorders [101,102], chronic symptomatic heart failure [103], atrial fibrosis [104], heart failure post-acute myocardial infarction [105], acute coronary syndrome [106], and acute cerebral infarction [107]. Currently, it is feasible to speculate on the molecular mechanism by which various nuclear lncRNAs operate during myocardial infarction [108], but not LIPCAR.…”

Section: Lipcarmentioning

confidence: 78%

Human mtDNA-Encoded Long ncRNAs: Knotty Molecules and Complex Functions

Bruni

2024

IJMS

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Until a few decades ago, most of our knowledge of RNA transcription products was focused on protein-coding sequences, which were later determined to make up the smallest portion of the mammalian genome. Since 2002, we have learnt a great deal about the intriguing world of non-coding RNAs (ncRNAs), mainly due to the rapid development of bioinformatic tools and next-generation sequencing (NGS) platforms. Moreover, interest in non-human ncRNAs and their functions has increased as a result of these technologies and the accessibility of complete genome sequences of species ranging from Archaea to primates. Despite not producing proteins, ncRNAs constitute a vast family of RNA molecules that serve a number of regulatory roles and are essential for cellular physiology and pathology. This review focuses on a subgroup of human ncRNAs, namely mtDNA-encoded long non-coding RNAs (mt-lncRNAs), which are transcribed from the mitochondrial genome and whose disparate localisations and functions are linked as much to mitochondrial metabolism as to cellular physiology and pathology.

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Section: Lipcarmentioning

confidence: 78%

Human mtDNA-Encoded Long ncRNAs: Knotty Molecules and Complex Functions

Bruni

2024

IJMS

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“…Some studies have evaluated the use of LncRNA to differentiate stroke etiologies. In a prospective observational study that included 80 Chinese patients with acute IS stroke (40 with LAA and 40 with cardioembolism), patients with cardioembolism had considerably higher plasma levels of long noncoding mitochondrially encoded long noncoding (lncRNA) cardiac-associated RNA (LIPCAR) than patients with LAA [ 41 ].…”

Section: Biomarkers Associated With Laa Strokementioning

confidence: 99%

“…These findings suggest that the levels of lncRNA LIPCAR and ZFAS1 may play a potential role in the distinction between LAA and other subtypes in patients with acute IS [ 41 , 42 ].…”

Section: Biomarkers Associated With Laa Strokementioning

confidence: 99%

Update on Biomarkers Associated with Large-Artery Atherosclerosis Stroke

Rosário

Fonseca

2023

Biomolecules

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Intracranial and extracranial large-artery atherosclerosis (LAA) are a main cause of ischemic stroke. Biomarkers may aid in the diagnosis of LAA and help to stratify patients’ risk of stroke. We performed a narrative review of the literature, mainly published in the last five years, with the aim of identifying biomarkers associated either with intracranial or extracranial LAA in humans. Several potential biomarkers of LAA, mainly related to lipidic pathways and inflammation, have been studied. Diagnostic biomarkers of LAA were evaluated by measuring biomarkers levels in patients with LAA stroke and other stroke etiologies. Some biomarkers were associated with the functional prognosis of LAA stroke patients. Increased levels of IL-6 and sLOX-1 were associated with a risk of progression of carotid atherosclerotic disease. Findings support the notion that the immune system plays a central role in the pathogenesis of LAA. Overall, in most studies, results were not externally validated. In the future, biomarkers could be useful for the selection of patients for clinical trials. To adopt these biomarkers in clinical practice, we will need robust multicentric studies proving their reproducibility and a clear practical applicability for their use.

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Diagnostic value and clinical significance of lncRNA LINC01123 combined with fibrinogen in acute cerebral infarction

Ding,

Wang

2024

Clinical Neurology and Neurosurgery

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Plasma lncRNA LIPCAR Expression Levels Associated with Neurological Impairment and Stroke Subtypes in Patients with Acute Cerebral Infarction: A Prospective Observational Study with a Control Group

Cited by 4 publications

References 41 publications

Human mtDNA-Encoded Long ncRNAs: Knotty Molecules and Complex Functions

Human mtDNA-Encoded Long ncRNAs: Knotty Molecules and Complex Functions

Update on Biomarkers Associated with Large-Artery Atherosclerosis Stroke

Diagnostic value and clinical significance of lncRNA LINC01123 combined with fibrinogen in acute cerebral infarction

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