Plasma lipoproteins in infantile visceral Leishmaniasis: deficiency of apolipoproteins A-I and A-II

Bekaert, Etienne D.; Kallel, R; Bouma, M.E.; Lontie, Jean-Francois; Mebazaa, Abderraouf; Malmendier, Claude; Ayrault-Jarrier, M

doi:10.1016/0009-8981(89)90288-x

Cited by 21 publications

(23 citation statements)

References 22 publications

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“…Hypertriglyceridemia was significantly higher in severe VL cases than mild/moderate group. Lipid disorders along with hypertriglyceridemia in VL cases have been reported earlier but none of them has ever studied the correlation between magnitude of serum triglyceride and the disease severity [16][17][18][19][20][21][22][23][26][27][28]. Recently, a study conducted on in vitro development of Leishmania donovani promastigotes exhibited that triglycerides are very much essential for Leishmania parasite growth [31].…”

Section: Discussionmentioning

confidence: 97%

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Hypertriglyceridemia: a possible diagnostic marker of disease severity in visceral leishmaniasis

Lal

Verma

et al. 2015

Infection

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Section: Discussionmentioning

confidence: 97%

“…The first case was reported in 1982 that described lipid disorders in an adult patient with kala-azar [16]. Thereafter, several studies revealed lipid disorders in children with active VL [17][18][19][20][21]. Severe hypocholesterolemia with reduced serum lipoprotein-alpha was reported in an adult patient with VL [22].…”

Section: Introductionmentioning

confidence: 97%

Hypertriglyceridemia: a possible diagnostic marker of disease severity in visceral leishmaniasis

Lal

Verma

et al. 2015

Infection

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“…Changes in the lipoproteins are known to occur in infantile visceral leishmaniasis, particularly, deficiency of apolipoprotein A-I and high density lipoproteins [30]. Apolipoprotein A-I is known to suppress neutrophil activation and inhibit endothelial expression of adhesion molecules [31].…”

Section: Discussionmentioning

confidence: 99%

Two-dimensional difference gel electrophoresis (DIGE) analysis of sera from visceral leishmaniasis patients

et al. 2011

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IntroductionVisceral leishmaniasis is a parasitic infection caused by Lesihmania donovani complex and transmitted by the bite of the phlebotomine sand fly. It is an endemic disease in many developing countries with more than 90% of the cases occurring in Bangladesh, India, Nepal, Sudan, Ethiopia and Brazil. The disease is fatal if untreated. The disease is conventionally diagnosed by demonstrating the intracellular parasite in bone marrow or splenic aspirates. This study was carried out to discover differentially expressed proteins which could be potential biomarkers.MethodsSera from six visceral leishmaniasis patients and six healthy controls were depleted of high abundant proteins by immunodepletion. The depleted sera were compared by 2-D Difference in gel electrophoresis (DIGE). Differentially expressed proteins were identified the by tandem mass spectrometry. Three of the identified proteins were further validated by western blotting.ResultsThis is the first report of serum proteomics study using quantitative Difference in gel electrophoresis (DIGE) in visceral leishmaniasis. We identified alpha-1-acidglycoprotein and C1 inhibitor as up regulated and transthyretin, retinol binding protein and apolipoprotein A-I as down regulated proteins in visceral leishmaniasis sera in comparison with healthy controls. Western blot validation of C1 inhibitor, transthyretin and apolipoprotein A-I in a larger cohort (n = 29) confirmed significant difference in the expression levels (p < 0.05).ConclusionsIn conclusion, DIGE based proteomic analysis showed that several proteins are differentially expressed in the sera of visceral leishmaniasis. The five proteins identified here have potential, either independently or in combination, as prognostic biomarkers.

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“…Elevated levels of triglycerides and low levels of HDL were observed in canine VL 28 . Changes in lipoproteins have also been reported in children with active VL [29][30][31] . Lipoproteins have the ability to modulate the immune response.…”

Section: Methodsmentioning

confidence: 96%

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

Gatto

Abreu

Tasca

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):735-740, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0198-2013 ABSTRACT Introduction: Visceral leishmaniasis (VL) is caused by the intracellular protozoan Leishmania donovani complex. VL may be asymptomatic or progressive and is characterized by fever, anemia, weight loss and the enlargement of the spleen and liver. The nutritional status of the patients with VL is a major determinant of the progression, severity and mortality of the disease, as it affects the clinical progression of the disease. Changes in lipoproteins and plasma proteins may have major impacts in the host during infection. Thus, our goal was evaluate the serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, glucose, albumin, globulin and total protein levels, as well as the body composition, of VL patients before and after treatment. Methods: Nutritional evaluation was performed using the bioelectrical impedance analysis (BIA) to assess body composition. Biochemical data on the serum total cholesterol, HDL, LDL, triglycerides, glucose, albumin, globulin and total protein were collected from the medical charts of the patients. Results: BIA indicated that both pre-treatment and post-treatment patients exhibited decreased phase angles compared to the controls, which is indicative of disease. Prior to treatment, the patients exhibited lower levels of total body water compared to the controls. Regarding the biochemical evaluation, patients with active VL exhibited lower levels of total cholesterol, HDL, LDL and albumin and higher triglyceride levels compared to patients after treatment and the controls. Treatment increased the levels of albumin and lipoproteins and decreased the triglyceride levels. Conclusions: Our results suggest that patients with active VL present biochemical and nutritional changes that are reversed by treatment. INTRODUCTION

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Plasma lipoproteins in infantile visceral Leishmaniasis: deficiency of apolipoproteins A-I and A-II

Cited by 21 publications

References 22 publications

Hypertriglyceridemia: a possible diagnostic marker of disease severity in visceral leishmaniasis

Hypertriglyceridemia: a possible diagnostic marker of disease severity in visceral leishmaniasis

Two-dimensional difference gel electrophoresis (DIGE) analysis of sera from visceral leishmaniasis patients

Biochemical and nutritional evaluation of patients with visceral leishmaniasis before and after treatment with leishmanicidal drugs

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