Plasma ?-lipoprotein pattern in acute viral hepatitis

Abstract

In the present study, the plasma levels of lipoproteins, triglycerides, and cholesterol were followed serially in a group of 57 patients with acute viral hepatitis. Mean plasma triglyceride levels were found elevated at the onset of the disease and gradually returned to normal, while mean plasma cholesterol values, low initially, gradually increased, alpha-lipoprotein was absent at the early stage of hepatitis in 41 out of 46 patients with mild or moderate course and reappeared gradually during the course of the disease. In 11 cases of viral hepatitis with impending or overt coma, alpha-lipoprotein was absent for the whole duration of the acute stage and never reappeared in those who eventually died, while it eventually returned to normal in those who survived. The reappearance of alpha-lipoprotein in acute viral hepatitis appears to be a sensitive index of improvement and a significant prognostic sign.

Serum total lipids, lipoprotein cholesterol, and apolipoprotein A in acute viral hepatitis and chronic liver disease.

“…Primary biliary cirrhosis behaved quite differently, in that total cholesterol was high, LP-X was present, and Apo A was nearly normal in five out of eight patients. PBC position in acute viral hepatitis has been reported (Mendenhall et al, 1962;K1or et al, 1972;Schmitz and Kahlke, 1973;Muller et al, 1974;Thalassinos et al, 1975;Vogt and Englhardt, 1975). The absence of a lipoprotein has been attributed to the impaired lipid-binding capacity of Apo A (Seidel et al, 1972).…”

“…The abnormal LDL that we found in four patients with marked cholestasis has been described by Klor et al (1972) as LDL III and by Muller et al (1974) as #2-LP. Muller et al (1974) The prognostic value of these parameters during the course of acute viral hepatitis has been pointed out (Thalassinos et al, 1975). In chronic liver disease, impairment of the synthetic ability of the liver, as indicated by routine biochemical tests, was associated with low levels of total cholesterol and Apo A.…”

“…The prognostic value of these parameters during the course of acute viral hepatitis has been pointed out (Thalassinos et al, 1975). In chronic liver disease, impairment of the synthetic ability of the liver, as indicated by routine biochemical tests, was associated with low levels of total cholesterol and Apo A.…”

High-density lipoprotein cholesterol improves the model for end-stage liver disease scoring system for prognostic prediction of acute liver failure

“…Reduced serum levels of high-density lipoprotein (HDL) cholesterol have been reported in ALF. The absence of alpha-lipoprotein was identified as a sensitive indicator of poor prognosis in acute viral hepatitis in 1975 [3]. After the establishment of biochemical tests to measure HDL cholesterol, strikingly reduced levels were shown in patients with ALF [4].…”

High-Density Lipoprotein Cholesterol and Liver Disease

“…Since high-density lipoprotein (HDL) is in large measure synthesized in the liver (12-14), any elevated HDLC might be affected in some way. Scattered reports over the past few decades have examined the relationship between HDLC and liver disease (10, 11, [14][15][16][17][18][19][20][21][22][23], but there is very little biopsy documentation of the type and degree of associated liver disease. This report examines and correlates the liver biopsies in alcoholic and nonalcoholic liver diseases with HDLC concentrations, and aminotransferase and prothrombin activities.…”