Plasma lipid risk factors in oophorectomized women

Montgomery, J. C.; Crook, David; Godsland, Ian F.; Wynn, V.; Studd, J. W. W.

doi:10.1111/j.1471-0528.1989.tb03206.x

Cited by 11 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 'dip' in HDL levels which we found up to six months posttreatment was also reported by Johansen et al (11) and Crook et al (13). Three short term studies, each involving less than 10 patients, reported no change (17,18) and a significant increase (19) in HDL cholesterol and apoprotein A levels after oophorectomy. The effects of endogenous oestrogen and pro¬ gesterone on HDL cholesterol and apoprotein levels are unclear.…”

Section: Discussionsupporting

confidence: 89%

Reversible menopause induced by the GnRH analogue buserelin: effects on lipoprotein metabolism

Farish

Fletcher

Barnes

et al. 1992

Acta Endocrinologica

View full text Add to dashboard Cite

GnRH agonists can induce a reversible pharmacological menopause and can be used to treat endometriosis, a fairly common gynaecological problem which responds well to oestrogen deprivation. Premature menopause is associated with adverse lipid changes and an increased risk of coronary heart disease. Therefore we set out to investigate changes in lipoprotein metabolism in a group of premenopausal women being treated with the GnRH analogue buserelin for active endometriosis. We monitored lipoprotein levels, high density lipoprotein subfractions and apolipoproteins AI, All and B during a 12-month course of treatment and for 6 months afterwards. Treatment caused a sustained increase in HDL3 cholesterol levels and a small increase in low density lipoprotein cholesterol, which was significant at the six-month visit only. Apolipoprotein B levels rose significantly and there were marginal increases in apolipoproteins AI and AII. All changes and trends were reversed after cessation of treatment. We conclude that the treatment did not profoundly affect lipoprotein metabolism, neither LDL nor HDL cholesterol, the established important risk markers for coronary heart disease appreciably altered.

show abstract

Section: Discussionsupporting

confidence: 89%

Reversible menopause induced by the GnRH analogue buserelin: effects on lipoprotein metabolism

Farish

Fletcher

Barnes

et al. 1992

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

“…This augmentation was distributed in cholesterol, triglycerides and phospholipids; but after 12 months the surgical treatment amplified this increase, as has been observed in postmenopausal women [3]. The lipid increase in ovariectomized rats was significant after 12 months for total cholesterol and also triglycerides, as also reported by some other authors [4]. It is important to note that the lipid peroxide level after 12 months was significantly increased in group OV compared with that in group C as already reported in postmenopausal women or after bilateral ovariectomy and in castrated mice [10,11].…”

Section: Discussionsupporting

confidence: 80%

“…Menopause is associated with adverse changes in lipids and lipoproteins, can be independent of any effects of age [3], and can be involved in CHD . Surgical castration in women resulted in little or no change in cholesterol concentrations, but an increase in triglyceride levels [4]. These changes in triglycerides were not observed by all investigators, for others reported only an early increase in total cholesterol and LDL cholesterol [5].…”

mentioning

confidence: 94%

Long-Term Ovariectomy Effect on Plasma Glucose,Lipids,Antioxidant Vitamins, and Lipid Peroxides: Relationship with Aortic Cholesterol and Fatty Acid Distribution in Rats.

Douillet

Borson‐Chazot

Renaud

et al. 1997

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

SummaryThis study was performed to determine plasma lipid changes and antioxidant status in relation to cholesterol content and fatty acid distribution in the aorta of rats after long-term ovariectomy (OV). After 12 months, OV induced in rat plasma a significant increase in glucose, total cholesterol, and triglycerides compared with the corresponding values for the control rats (C) of the same age (p <0.0005, p < 0.005, p<0.0005, respectively). These changes were associated with a significant increase in lipid peroxide level (p <0.05) and a significant decrease in vitamin E in the plasma from group OV compared with the group C level (p<0.0001). Conversely, OV after 7 and 12 months induced a significant increase in vitamin C (p<0.001, p<0.0001, respectively). Concerning plasma fatty acid distribution, after 12 months, OV caused a significant increase in gamma and dihomo gamma linolenic acid (p < 0.0005, p<0.05, respectively). These changes were associated with a significant increase in aortic cholesterol in group OV (p<0.0005), and a significant decrease in the percentage of arachidonic acid (p <0.005) and of the total amount of fatty acids of the n-3 series (p<0.0001) and plasmalogen fatty acids (C16:0, p < 0.005; C 18:0, p < 0.05) compared with the corresponding values for group C. These results show that OV induced, independently of any effects of aging, plasma-specific lipid alterations with dysregulation of oxidative status, which could be crucial in the development of atherothrombotic disease.

show abstract

“…Similarly, Griffin et al (1993) recently reported that total HDL and HDL2 cholesterol and APO A-I were significantly increased after 16 weeks of treatment with estrogen among a group of 12 women who had undergone BSO and were attending a menopause clinic, relative to a placebo group of 5 BSO cases. Nonetheless, two other prospective studies with clinical populations have found no changes in HDL levels pre-to postsurgery among oophorectomized women (Montgomery et al, 1989; Punnonen & Rauramo, 1980). Thus, the present study is the first to identify adverse changes in HDL and HDL2 associated with BSO in a population-based sample of middle-aged women.…”

Section: Discussionmentioning

confidence: 91%

“…Lipoprotein measurements were not available in that study. Several other longitudinal studies with small patient populations suggest that surgical menopause may not have atherogenic effects on lipids or may have only transient effects up to 7 months postoperatively (Montgomery, Crook, Godsland, Wynn, & Studd, 1989; Punnonen & Rauramo, 1976, 1980).…”

mentioning

confidence: 99%

Effects of surgical menopause on psychological characteristics and lipid levels: The Healthy Women Study.

Everson¹,

Matthews²,

Guzick³

et al. 1995

Health Psychology

View full text Add to dashboard Cite

The authors examined the effects of surgical menopause, with or without hormone replacement therapy (HRT), on psychosocial functioning and lipid levels in a population-based study of initially premenopausal women. Within 5 years of study entry, 28 women underwent hysterectomy, with 9 retaining their ovaries and 19 having bilateral salpingo oophorectomy (BSO), and with 173 premenopausal women as a comparison group. Women undergoing hysterectomy reported fewer stress symptoms and a more optimistic attitude at follow-up, whereas BSO cases without HRT had lower mean total high-density lipoprotein (HDL) and HDL2, relative to premenopausal women. Subject to limited power, the authors' findings suggest that surgical menopause among middle-aged women does not lead to negative psychological outcomes but that BSO in the absence of hormone use has significant adverse effects on the HDL and HDL2.

show abstract

Plasma lipid risk factors in oophorectomized women

Cited by 11 publications

References 18 publications

Reversible menopause induced by the GnRH analogue buserelin: effects on lipoprotein metabolism

Reversible menopause induced by the GnRH analogue buserelin: effects on lipoprotein metabolism

Long-Term Ovariectomy Effect on Plasma Glucose,Lipids,Antioxidant Vitamins, and Lipid Peroxides: Relationship with Aortic Cholesterol and Fatty Acid Distribution in Rats.

Effects of surgical menopause on psychological characteristics and lipid levels: The Healthy Women Study.

Contact Info

Product

Resources

About