Plasma lipid levels in gout.

Abstract

A number of investigations have previously been carried out to examine inter-relationships between hypercuricaemia, gout, and levels of plasma lipids, usually with particular reference to glycerides and cholesterol. The present study was designed to compare the levels not only of glycerides and cholesterol, but also of phospholipids and free fatty acids, in gout patients with those in a group of very closely matched control subjects; and to determine, in the gout patients, whether there was any relationship between levels of these lipid fractions and the endogenous production of uric acid as measured by urinary levels of uric acid on a low-purine diet.Plan of study 27 British patients with primary gout (25 men and 2 women) participated in the study. Some of them were on urate-lowering treatment (allopurinol or uricosuric agents) at the time when blood was taken for lipid estimations, but plasma and urinary levels of uric acid had been estimated on a low-purine diet before treatment was started.A control group of 27 subjects was taken from hospital patients suffering from a wide variety of medical and surgical conditions. None had gout or hyperuricaemia; all were of reasonable social orientation, all were taking normal diets and none was grossly obese. Initial investigations in all subjects, gout and control, excluded predisposing causes for hyperlipidaemia. The control group was matched with gout patients for age, sex, blood pressure, alcohol intake, and the presence of ischaemic vascular disease. The two groups were also matched for ponderal index 13igh (in.) which tends to be lower \VYweight (lb.)

Serum Uric Acid: Correlation with Biological, Clinical and Behavioral Factors in Japanese Men

“…A number of clinical studies have asserted that hyperuricemia or gout is positively associated with triglyceride 21,22,23). Not many population studies have addressed the relation between triglyceride and SUA.…”

Gout and its relation to lipid metabolism. I. Serum uric acid, lipid, and lipoprotein levels in gout.

“…Harris-Jones (1957) reported that the serum uric acid level was often elevated in patients with essential hyperlipoproteinemia. Strejcek and Kucerova' (1968) demonstrated the incidence of gout in patients with high serum lipid levels, and the same phenomenon was observed by Berkowitz (1964), Feldman and Wallace (1964), Barlow (1966), Benedek (1967), Gunther, Herbst, and Knapp (1967) and Darlington and Scott (1972). Investigations in which all the serum lipids and lipoproteins are determined in patients with gout and a control group are rare.…”

Abnormal Renal Urate Homeostasis in Systemic Disorders

“…Recent studies have shown the most common lipid abnormality to be hypertriglyceridaemia [6,10,13,44], rather than hypercholesterolaemia, as first suggested. This greater incidence of hypertriglyceridaemia in patients with primary gout was not explicable by the associated obesity or by alcohol consumption [42], and the triglyceride increases were usually associated with increases in both phospholipid and free fatty acid concentrations [26], One explanation for this association of hypertriglyceridaemia with hyper uricaemia is that, while the disorder of lipid metabolism may be the primary disorder, the associated hyperuricaemia, presenting as gouty arthritis, induces the first symptom in the patient. In such a case, the hyperlipoproteinaemia remains unrecognized until sought specifically [3], An alternative explanation of the association of hyperuricaemia and hypertriglyceridaemia might be that they are both secondary to another abnormality.…”