Plasma Lipid Levels at Diagnosis in Type 2 Diabetic Patients

Sosenko, Jay M.; Kato, Marta M; Soto, Ramon; Goldberg, Ronald

doi:10.1111/j.1464-5491.1993.tb00172.x

Cited by 9 publications

(9 citation statements)

References 25 publications

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“…These changes failed to correlate with the degree of glycaemic control, urinary albumin or the duration of disease although levels of E-selectin correlated with increased levels of LDL and vWf with hypertension. In common with the findings of others, the risk factor profile of the patients differed markedly from that of the controls: there was more hypertension, hypertriglyceridaemia, smoking and increased LDL among the patients whilst HDL was lower (18)(19)(20).…”

Section: Discussionsupporting

confidence: 81%

Increased Levels of Soluble Adhesion Molecules in Type 2 (Non-Insulin Dependent) Diabetes mellitus Are Independent of Glycaemic Control

et al. 1994

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SummaryPatients with Type 2 (non-insulin dependent) diabetes mellitus are at increased risk of thrombosis and the premature development of atherosclerosis. This may be related to damage to the endothelium (which may be the primary target tissue for the disease process) resulting from a loss of normal glycaemic metabolic control. Thus changes in endothelial cell function, such as modified release of soluble leukocyte and platelet adhesion molecules, may be important. Accordingly, E-selec-tin, von Willebrand factor (vWf), vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM) were measured in serum from 60 patients and 76 controls. Raised levels of vWf (p = 0.0002), E-selectin (p <0.0001) and VC AM (p = 0.003) in patient’s samples failed to correlate with glycaemic control as assessed by levels of fructosamine and glycated haemoglobin, or with 24 h urine albumin. Levels of ICAM were not increased in our patients. Levels of the two endothelial cell products, vWf and E-selectin, failed to correlate although E-selectin correlated with low density lipoprotein cholesterol (p = 0.016). vWf correlated with VCAM (p <0.001) and hypertension (p = 0.032). We conclude that levels of soluble adhesion molecules vWf, E-selectin and VCAM are raised in Type 2 diabetes mellitus. The mechanisms for these changes appear to be independent of glycaemic control but may relate to concurrent hypertension and/or hypercholes-terolaemia.

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Section: Discussionsupporting

confidence: 81%

Increased Levels of Soluble Adhesion Molecules in Type 2 (Non-Insulin Dependent) Diabetes mellitus Are Independent of Glycaemic Control

et al. 1994

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“…In our study the mean values of total cholesterol among male and female diabetic hypertensives and controls did not vary significantly, suggesting that diabetic dyslipidemias do not alter total cholesterol levels significantly. Similar results were observed by Sosenko et al [10] who also had lower levels of HDL-C. In our study the mean values of HDL-C among male and female diabetic hypertensives were significantly lower than that of controls.…”

Section: Discussionsupporting

confidence: 92%

“…As the age advances the occurrence of diabetes and hypertension increases, relating to this in the present study the mean age of male and female diabetic hypertensives is significantly higher than that of controls. Han et al [9] and Sosenko et al [10] also had the mean age in the same range. In our study the mean BMI of male diabetic hypertensives is 25.80 and female diabetic hypertensives is 26.36, suggesting that they are overweight and the mean waist circumference was significantly higher in male and female diabetic hypertensives than controls.…”

Section: Discussionmentioning

confidence: 76%

Correlation of plasma fibrinogen and lipoproteins in diabetic hypertensive patients

Rachaiah¹,

Malleshappa²

2012

Int J Med Sci Public Health

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Background: Diabetic hypertensive patients have higher cardiovascular morbidity and mortality than general population. Various risk factors like age, BMI (Body mass index), hypertension, smoking, dyslipidemia, etc. have been extensively studied, but still these together cannot explain increased cardiovascular morbidity and mortality in diabetes. Several studies have shown that fibrinogen is a powerful independent risk factor for cardiovascular disease. Hence fibrinogen levels and its correlation to lipoproteins in diabetic hypertensives were studied. Objective: To estimate plasma fibrinogen levels in patients with type 2 diabetes mellitus and hypertension and to correlate plasma fibrinogen with Lipoproteins and also with BMI. Materials and Methods: A Prospective cross sectional study conducted in a tertiary care hospital. Data collected by simple random sampling method and analysis of various parameters done by using chi square-test and correlated with pearson's correlation coefficient "r". Results: The higher plasma fibrinogen levels were found in diabetic hypertensives (449.06 ± 131.26) when compared to controls. The mean total cholesterol, TG (triglycerides), LDL (Low density lipoprotein), VLDL (Very low density lipoprotein), HDL (High density lipoprotein) among cases were 195.82 ± 26.92 mg/dl, 243.62 ± 45.83 mg/dl, 104.15 ± 25.76 mg/dl, 48.72 ± 9.17 mg/dl, 38.21 ± 4.03 mg/dl respectively and the mean BMI of cases was 26.16 ± 5.36 kg/m 2. The plasma fibrinogen is positively correlated to BMI and total cholesterol levels which is statistically significant. Conclusion: The plasma fibrinogen levels could potentially be considered for screening programs to identify people at high risk of vascular events.

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“…Previous studies have reported inconsistent results for plasma lipids and lipoproteins in male and female NIDDM patients (10)(11)(12)(13)(14)(15), which may be explained by small sample size and the heterogeneous nature of the diabetic population studied. The largest study was based on the National Health and Nutrition Examination Survey (NHANES) II, a population-based study in U.S., and comprised over 600 white NIDDM patients (11); only three studies (12)(13)(14) have reported data for newly diagnosed, untreated patients.…”

Section: Conclusion -Cardiovascularmentioning

confidence: 89%

U.K. Prospective Diabetes Study 27: Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex

1997

Diabetes Care

120

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Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex U.K. PROSPECTIVE DIABETES STUDY GROUP OBJECTIVE-To compare fasting plasma lipids and lipoproteins in male and female patients at diagnosis of NIDDM and to examine age and sex differences in lipid concentrations. RESEARCH DESIGN A N D METHODS-Cross-sectional study of fasting plasma total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride in 2,139 male and 1,574 female white patients, aged 25-65 years, at diagnosis of NIDDM.RESULTS -At diagnosis of NIDDM, the mean age ± SD for men was 52 ± 9 and 53 ± 9 years for women; BMI was 28.3 ± 4.9 and 30.8 ±6.7 kg/m 2 , and fasting plasma glucose was 11.6 ± 3.6 and 12.4 ± 3.8 mmol/1, respectively. The mean total and LDL cholesterol were higher in female than in male NIDDM patients, 5.8 ± 1.2 vs. 5.5 ±1.1 and 3.9 ±1.1 vs. 3.6 ± 1.0 mmol/1 (both P < 0.001), respectively, while triglyceride levels were similar: geometric mean (1 SD interval) for men and women was 1.8 (1.1-3.1) vs. 1.8 (1.1-2.9) mmol/1. HDL cholesterol was higher in female than in male NIDDM patients, 1.09 ± 0.2 vs. 1.01 ± 0.24 mmol/1 (P < 0.001); the sex differential for HDL cholesterol was 7% in NIDDM patients compared with 22% in the general population. Data analysis by 5-year age bands showed a significant trend toward lower total cholesterol and triglyceride and higher HDL cholesterol in men diagnosed above the age of 50 years. In female NIDDM patients, lipid concentrations increased with age of diagnosis but reached a plateau above the age of 50 years. CONCLUSIONS-The effect of NIDDM, observed at diagnosis, on plasma lipid and lipoprotein levels is more pronounced in women than in men. This may explain in part why the cardiovascular risk is proportionally higher in female patients.

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Plasma Lipid Levels at Diagnosis in Type 2 Diabetic Patients

Cited by 9 publications

References 25 publications

Increased Levels of Soluble Adhesion Molecules in Type 2 (Non-Insulin Dependent) Diabetes mellitus Are Independent of Glycaemic Control

Increased Levels of Soluble Adhesion Molecules in Type 2 (Non-Insulin Dependent) Diabetes mellitus Are Independent of Glycaemic Control

Correlation of plasma fibrinogen and lipoproteins in diabetic hypertensive patients

U.K. Prospective Diabetes Study 27: Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex

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