Plasma lipid and coagulation factor concentrations in insulin dependent diabetics with microalbuminuria.

Jones, Susan Y.; Close, C. F.; Mattock, M. B.; Jarrett, R. J.; Keen, H.; Viberti, Giancarlo

doi:10.1136/bmj.298.6672.487

Cited by 213 publications

(90 citation statements)

References 33 publications

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“…This approach, used by other investigators [20], gives results which correlate well with those from 24-h urine collections. The finding that increased AER is associated with increased blood pressure, is a conclusion reached in previous studies on non-diabetic subjects [30], in subjects with IDDM [25][26][27], and in subjects with NIDDM [20]. In the present study the relationships between blood pressure AER and SLC were present which ever value of AER was used to define microalbuminuria.…”

Section: Discussionsupporting

confidence: 68%

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The relationship of urinary albumin excretion rate to ambulatory blood pressure and erythrocyte sodium-lithium countertransport in NIDDM

et al. 1995

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SummaryIncreased erythrocyte sodium-lithium countertransport rate is found in non-diabetic subjects with essential hypertension, and in insulin-dependent diabetic subjects with nephropathy. However, relationships between these variables in non-insulin-dependent diabetic subjects are ill-defined. In order to characterise the relationships between blood pressure, urinary albumin excretion, and erythrocyte sodium-lithium countertransport, 66subjects with non-insulin-dependent diabetes were studied. Urinary albumin excretion rate correlated with mean 24-h ambulatory systolic blood pressure (r = 0.57; p < 0.001), but not with sodium-lithium countertransport (r = 0.06; p = 0.31). No significant relationship was observed between 24-h systolic blood pressure and erythrocyte sodium-lithium countertransport (r= 0.16; p = 0.17). The principal differences between microalbuminuric and normoalbuminuric subjects In conclusion, albumin excretion rates in non-insulin-dependent diabetic subjects are linked to hypertension and glycaemic exposure, but show no relationship to erythrocyte sodium-lithium countertransport. [Diabetologia (1995) 38: 356-362]

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Section: Discussionsupporting

confidence: 68%

“…The present study found relationships between the duration of diabetes, HbA1, and AER, suggesting cumulative glycaemic exposure is also a possible determinant of increased AER in subjects with NIDDM, as is well established in IDDM [25][26][27][28].…”

Section: Discussionmentioning

confidence: 98%

The relationship of urinary albumin excretion rate to ambulatory blood pressure and erythrocyte sodium-lithium countertransport in NIDDM

et al. 1995

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“…The mechanisms which contribute to lipid abnormalities in CRF patients are not clearly understood. It is possible that, there is a genetic link between the two abnormalities, or kidney themselves play an important role in lipid metabolism which is disturbed by onset of proteinuria (4). Increased LDL levels, decreased HDL levels have been reported in patients with diabetes and microabuminuria.…”

Section: Introductionmentioning

confidence: 99%

Lipid abnormalities in chronic renal failure

Bhagwat

Joshi

Salgia

et al. 1997

Indian J Clin Biochem

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:Lipid abnormalities remain to be a major cause of early mortality in patients with chronic renal failure (CRF). In present study, 114 (one hundred fourteen) CRF patients without any additional cause of dyslipidemia were divided into groups on the basis of etiologies of CRF. Blood samples from each group were analyzed for total cholesterol, triglyceride and HDL cholesterol along with blood urea nitrogen and serum creatinine. 25 healthy individuals without any obvious disease were taken as control. Patients from all the groups showed a marked hypertriglyceridemia of 232 (SD + 77) mg/dl (P < 0.001) as compared to control. Levels of HDL cholesterol were found to be significantly low 20 ( ~ 11) mg/dl (p < 0.001) in all the groups. LDL cholesterol showed an increase 104 ( _+ 30) mg/dl as compared to control group which is not statistically significant. Present study reveals that, CRF patients show an uniform dyslipidemia irrespective of etiologies leading to CRF. This dyslipidemia is also independent of serum creatinine levels. Although, these lipid abnormalities may not solely cause mortality in CRF patients, they may act as modulators in accelerating atherogenesis which in turn cause early mortality in CRF patients.

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“…[6][7][8] In addition, persons with dyslipidaemia frequently have increased levels of atherogenic small dense LDL and cholesterol-rich remnant lipoproteins. [9][10][11] Hence, MA may signal the presence of lipoprotein abnormalities that could play an important role in the increased risk of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Impact of an ACE inhibitor and calcium antagonist on microalbuminuria and lipid subfractions in type 2 diabetes: a randomised, multi-centre pilot study

Bakris¹,

Smith²,

Richardson³

et al. 2002

J Hum Hypertens

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Background: Microalbuminuria (MA) is associated with increased cardiovascular risk and lipid abnormalities in people with type 2 diabetes. ACE inhibitors and calcium channel blockers (CCBs) reduce MA and are neutral on total cholesterol and triglycerides. The effect of ACE inhibitors and CCBs on lipid subfractions such as Lp(a), apolipoprotein (apo) A1, apo B, and others, however, is unclear. The current study tests the hypothesis that a fixed-dose combination of an ACE inhibitor, benazepril (B) with the dihydropyridine CCB, amlodipine (A), will further reduce arterial pressure and reduce atherogenic lipid fractions compared to either agent alone. Design: A multicentre, randomised, open-label, parallel group design was used to study 27 participants with type 2 diabetes. Measurements for total cholesterol, high-and low-density lipoprotein (HDL and LDL), triglycerides, apo A1, apo B, Lp(a), MA, arterial pressure and creatinine clearance were obtained at baseline and at 12-week intervals during the 36 week study. Results: Arterial pressure was significantly reduced at 36 weeks in all three groups (P ‫؍‬ 0.0078 for A, P ‫؍‬

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Plasma lipid and coagulation factor concentrations in insulin dependent diabetics with microalbuminuria.

Cited by 213 publications

References 33 publications

The relationship of urinary albumin excretion rate to ambulatory blood pressure and erythrocyte sodium-lithium countertransport in NIDDM

The relationship of urinary albumin excretion rate to ambulatory blood pressure and erythrocyte sodium-lithium countertransport in NIDDM

Lipid abnormalities in chronic renal failure

Impact of an ACE inhibitor and calcium antagonist on microalbuminuria and lipid subfractions in type 2 diabetes: a randomised, multi-centre pilot study

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