Plasma lipid and apolipoprotein concentrations in full term infants fed formula supplemented with long-chain polyunsaturated fatty acids and cholesterol

Décsi, Támas; Fekete, M; Koletzko, Berthold

doi:10.1007/s004310050624

Cited by 12 publications

(8 citation statements)

References 19 publications

(18 reference statements)

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“…This lack of a difference might be due to the fact that the infants were studied in the period when enteral feeding had just started. However, the concentrations were similar to values observed previously in newborn infants (41,42).…”

Section: Discussionsupporting

confidence: 90%

Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants

Demmelmair

Feldl

Horváth

et al. 2001

Lipids

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Several studies have reported that feeding gamma-linolenic acid (GLA) has resulted in no increase in arachidonic acid (AA) in newborns. This result was ascribed to the eicosapentaenoic acid (EPA)-rich fish oil used in these formulas. Docosahexaenoic acid (DHA) sources with only minor amounts of EPA are now available, thus the addition of GLA to infant formulas might be considered an alternative to AA supplementation. Sixty-six premature infants were randomized to feeding one of four formulas [ST: no GLA, no long-chain polyunsaturated fatty acids; BO: 0.6% GLA (borage oil); BO + FOLOW: 0.6% GLA, 0.3% DHA, 0.06% EPA; BO + FOHIGH: 0.6% GLA, 0.3% DHA, 0.2% EPA] or human milk (HM, nonrandomized) for 4 wk. Anthropometric measures and blood samples were obtained at study entry and after 14 and 28 d. There were no significant differences between groups in anthropometric measures, tocopherol, and retinol status at any of the studied time points. The AA content of plasma phospholipids was similar between groups at study start and decreased significantly until day 28 in all formulafed groups, but not in the breast-fed infants [ST: 6.6 +/- 0.2%, BO: 6.9 +/- 0.3%, BO + FOLOW: 6.9 +/- 0.4%, BO + FOHIGH: 6.7 +/- 0.2%, HM: 8.6 +/- 0.5%, where values are reported as mean +/- standard error; all formulas significantly different (P< 0.05) from HM]. There was no significant influence of GLA or fish oil addition to the diet. GLA had only a very limited effect on AA status which was too small to obtain satisfactory concentrations (concentrations similar to breast-fed babies) under the circumstances tested. The effect of GLA on AA is independent of the EPA and DHA content in the diet within the dose ranges studied.

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Section: Discussionsupporting

confidence: 90%

Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants

Demmelmair

Feldl

Horváth

et al. 2001

Lipids

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“…The term infants fed supplemented formula and cholesterol showed significantly greater cholesterol and triglyceride concentrations than infants receiving conventional formula on days 5 and 30. Thereafter, no appreciable effects of diet on plasma phospholipid, triglyceride, cholesterol, lipoprotein cholesterol and apolipoprotein concentrations were observed (65). Nucleotide-supplemented formulae increase total apolipoprotein concentrations and therefore affect cholesterol metabolism (66,67).…”

Section: Cholesterolmentioning

confidence: 99%

Role of infant dietary long-chain polyunsaturated fatty acids, liposoluble vitamins, cholesterol and lecithin on psychomotor development

Cockburn¹

2003

Acta Paediatrica

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“…A composição nutricional do leite humano, especialmente em relação ao componente lipídico, apresenta variações biológicas inerentes ao processo da lactação 30,31,32 . Durante a mamada existe uma elevação significativa do conteúdo de gorduras, possuindo o leite final ou posterior por volta de três vezes a concentração lipídica do leite inicial ou anterior.…”

Section: Composição Lipídicaunclassified

“…Não foram detectadas alterações nos valores de ácidos graxos entre o início e o fim da mamada. Estas diferenças entre os leites inicial e final poderiam ser decorrentes do fenômeno mecânico de absorção dos glóbulos de gordura à superfície secretora e aos dutos dos alvéolos mamários, resultando em sua liberação tardia durante a mamada 30 .…”

Section: Composição Lipídicaunclassified

Composição do leite humano: o alimento ideal

Calil

Falcão

2003

Rev. Med. (São Paulo)

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Todas as mães devem ser encorajadas a oferecer seu próprio leite para seus filhos. Apesar do advento das fórmulas infantis, nenhuma dessas se equipara ao leite humano. O leite humano possui inúmeras vantagens: aspectos higiênicos, imunológicos, psico-sociais e cognitivo, bem como aquelas relativas à prevenção de doenças futuras; devem ser consideradas ainda as vantagens econômicas provenientes do menor custo e do efeito anticoncepcional, bem como os benefícios do aleitamento sobre o organismo materno. O leite humano possui uma composição nutricional balanceada em termos de proteínas, carboidratos e gorduras, promovendo crescimento e desenvolvimento adequados. Por isto, aalimentação de recém-nascidos e lactentes com o leite de suas próprias mães é recomendado durante dois primeiros anos de vida.

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Plasma lipid and apolipoprotein concentrations in full term infants fed formula supplemented with long-chain polyunsaturated fatty acids and cholesterol

Cited by 12 publications

References 19 publications

Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants

Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants

Role of infant dietary long-chain polyunsaturated fatty acids, liposoluble vitamins, cholesterol and lecithin on psychomotor development

Composição do leite humano: o alimento ideal

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