Plasma LH and FSH Response to LRH in Boys with Compensatory Testicular Hypertrophy

Laron, Zvi; Dickerman, Z; Prager-Lewin, R; Keret, R; Halabe, E.

doi:10.1210/jcem-40-6-977

Cited by 33 publications

(9 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This mechanism is probably similar to that previously reported by us in boys with unilateral compensatory testicular hypertrophy in unilateral hypogonadism (Laron et al 1975), but most probably transitory in nature. It is possible that the cause is a delay in the maturation mechanism of 5a-reducticn of testosterone (T) to dihydrotestosterone (DHT).…”

Section: Discussionsupporting

confidence: 89%

Plasma Lh and FSH Response to LRH and Plasma Testosterone Levels in Boys With Irregular Puberty

Dickerman

Bar-Haim

Prager-Lewin

et al. 1977

Acta Endocrinologica

View full text Add to dashboard Cite

Nineteen boys with irregular puberty (IP), defined as a discrepancy of two or more pubertal stages between the criteria for genitalia and that for pubic hair, were subjected to a standard LRH test (50 \g=m\g/m2, iv) and the response of gonadotrophins as well as the basal levels of plasma testosterone, LH and FSH were compared to those of boys with normal, regular puberty. When the results were plotted against the pubertal stage for genitalia (Pg), it was found that in the boys with IP the basal plasma testosterone levels were lower and the response of plasma LH to LRH stimulation lesser than in the controls. However, when these parameters were plotted against the pubertal stage for pubic hair (Ph) it was found, that in the boys with IP the plasma testosterone levels were significantly higher and the response of both LH and FSH stimulation greater than in the control group.It was concluded that irregular puberty in boys may be regarded as a normal variation. The delayed development of sexual hair and penile length, and retarded pubertal growth spurt and bone age maturation seen in these boys, with normal testicular development, may be explained by a temporary reduced peripheral sensitivity to androgens and a compensatory effort by the pituitary, manifested in increased secretion of LH and testosterone, relatively to their pubertal stage for pubic hair.

show abstract

Section: Discussionsupporting

confidence: 89%

Plasma Lh and FSH Response to LRH and Plasma Testosterone Levels in Boys With Irregular Puberty

Dickerman

Bar-Haim

Prager-Lewin

et al. 1977

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

“…However, the increase of the LH secretion in the 5 children with CTH led us to speculate on a different mechanism in these children. The data published by Laron et al (7) are in agreement with these findings.…”

Section: Resultssupporting

confidence: 81%

“…It was first described by Laron and Zilka (8) in 1969. Oversecretion of follicle-stimulating hormone (FSH), either basal or after stimulation by LRH, and of luteinizing hormone (LH) only after stimulation, was reported in these subjects at pubertal age (7).…”

mentioning

confidence: 99%

Unilateral Cryptorchidism with Compensatory Hypertrophy of Descended Testicle in Prepubertal Boys

Tatò¹,

Corgnati²,

Boner³

et al. 1978

Horm Res

View full text Add to dashboard Cite

5 prepubertal boys with unilateral cryptorchidism and compensatory hypertrophy of the descended testicle, 22 prepubertal boys with unilateral cryptorchidism and without CTH, and 14 prepubertal normal boys were submitted to LH-RH and to HCG tests in order to study the hormonal behaviour in CTH phenomenon before puberty. High but normal peaks of plasma LH and FSH were observed after LH-RH in CTH boys who showed a significant increase of testosterone after HCG stimulation. On the contrary the LH response to LH-RH and the testosterone response to HCG of the boys with unilateral cryptorchidism and without CTH were, as expected, significantly lower than in the control ones.

show abstract

“…The biological potency of 1 mg is 20 IU of FSH and 48 IU of LH. Plasma testosterone was measured by RIA, with some modification of the method ofWeinstein et al as described by Laron et al [18]. LH-RH tests were performed after an overnight fast on an ambulatory basis by injecting synthetic LH-RH (Ferring, Sweden) 50 mcg/m 2 i.v.…”

Section: Methodsmentioning

confidence: 99%

Puberty in 24 patients with Klinefelter syndrome

et al. 1982

Self Cite

View full text Add to dashboard Cite

Abstract. Twenty four boys with Klinefelter syndrome, 18 of whom were diagnosed prepubertally, were observed until adulthood. Onset of puberty, as judged from testicular enlargement and pubic hair development, occurred between 11 to 14 years in the above 18 patients. By the age of 17 pubic hair, penile length and height had reached the adult stage in all patients, but arrest of testicular growth was noted at midpuberty, 13 years, with maximal mean (+_ SD) volume attained being 3.5 4-1.5 ml. The first conscious ejaculation was reported to have occurred between 13 to 16 years in 10 patients and in the remaining 4 between 17 to 18 years of age. Sperm counts obtained after the age of 18 revealed azospermia or severe oligospermia in all patients except one, who had a sperm count of 30 • 106/ml. The hypothalamic-pituitary-gonadal axis, assessed by LH-RH and hCG stimulation tests, was found to be normal in prepuberty and during early pubertal stages. From mid-puberty the basal levels of plasma FSH and the response to LH-RIt showed a gradual increase above the normal. Towards late puberty (> 15 years) basal and peak levels of LH were above normal with a concomitant decrease in the basal level of testosterone and its response to hCG.These findings indicate that during childhood and early puberty function of the hypothalamic-pituitary-gonadal axis is normal in Klinefelter syndrome, allowing the onset of pubertal signs at the appropriate age, and that until late puberty there is a relative preservation of function in the testicular Leydig cells, permitting the normal sequential development of the androgen-dependent pubertal signs. The measurement of testicular testosterone reserve by means of hCG stimulation constitutes a useful aid in determining when and if testosterone replacement therapy should be instituted. Key words: Klinefelter syndrome -PubertyThe clinical, hormonal and histological picture of Klinefelter syndrome has been given wide attention in the literature since the original description published in 1942 [13]. Histological studies indicate that testicular damage is already present in the perinatal and prepubertal periods [15,21]. The progression of these changes during puberty has been found to lead to faulty spermatogenesis [10] as well as a decrease in testosterone production and secretion by the testes [14,31] with signs of hypovirilization in most of these patients [8].Reprint requests to: Prof. Z. Laron, Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical Center, Petah Tikva 49 100, Israel Presented here are the findings made during long-term follow-up in 24 patients with Klinefelter syndrome, most of whom had been diagnosed before puberty. It was the aim of this study to investigate the sequence of the clinical and hormonal changes taking place and their inter-relationships, before and during puberty. Patients and MethodsThe patient material comprised 24 patients in all of whom the diagnosis of Klinefelter syndrome was confirmed by chromosomal studies. In 18, diagnosis was made before ...

show abstract

Plasma LH and FSH Response to LRH in Boys with Compensatory Testicular Hypertrophy

Cited by 33 publications

References 1 publication

Plasma Lh and FSH Response to LRH and Plasma Testosterone Levels in Boys With Irregular Puberty

Plasma Lh and FSH Response to LRH and Plasma Testosterone Levels in Boys With Irregular Puberty

Unilateral Cryptorchidism with Compensatory Hypertrophy of Descended Testicle in Prepubertal Boys

Puberty in 24 patients with Klinefelter syndrome

Contact Info

Product

Resources

About