1986
DOI: 10.1002/jps.2600751118
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Plasma Levels of the Prodrug, Arbaprostil, [(15R)-15-Methylprostaglandin E2], and its Active, Antiulcer (15S) Epimer in Humans after Single Dose Oral Administration

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Cited by 9 publications
(1 citation statement)
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“…While the chemical structure of the unknown compound cannot be conclusively related to limonin on the basis of the information available, its appearance in the plasma of the human subjects confirms that another compound with the same molecular weight as limonin is produced in humans administered high doses of limonin glucoside. Previous reports of epimerization of chiral centers of steroidal (25), prostaglandin (26), imidazole (27), and alkaloid (28) drug metabolites in humans illustrates epimerization in human metabolism and supports the theory that the epimerization of limonin to epilimonin may proceed in the metabolism of limonin glucoside by humans.…”
Section: Discussionsupporting
confidence: 62%
“…While the chemical structure of the unknown compound cannot be conclusively related to limonin on the basis of the information available, its appearance in the plasma of the human subjects confirms that another compound with the same molecular weight as limonin is produced in humans administered high doses of limonin glucoside. Previous reports of epimerization of chiral centers of steroidal (25), prostaglandin (26), imidazole (27), and alkaloid (28) drug metabolites in humans illustrates epimerization in human metabolism and supports the theory that the epimerization of limonin to epilimonin may proceed in the metabolism of limonin glucoside by humans.…”
Section: Discussionsupporting
confidence: 62%