Plasma Levels Of SRAGE Do Not Predict Postextubation Distress After A Successful Weaning Trial

Jabaudon, Matthieu; Parratte, Sébastien; Soummer, Alexis; Roszyk, Laurence; Guerin, R; Futier, Emmanuel; Lü, Qin; Bazin, J. E.; Sapin, Vincent; Rouby, Jean Jacques; Constantin, Jean Michel

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3093

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“…In the same panel of present results, Soummer et al [9] studied the role of lung US in detecting lung aeration during post-extubation stress in 100 patients and found that less lung aeration usually means re-intubation i.e., weaning failure. In another research done by Perbet et al [20], authors evaluated the role of the soluble form of the receptor for advanced glycogen end products (SRAGE) as a serum marker to denote lung epithelial injury and ineffective lung aeration in cases of post-extubation stress. In this study, they depended on lung US as a standard predictor of lung aeration.…”

Section: Discussionmentioning

confidence: 99%

Diaphragm and Lung Ultrasound Indices in Prediction of Outcome of Weaning from Mechanical Ventilation in Pediatric Intensive Care Unit

2020

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Objective To predict the added value of diaphragmatic and lung ultrasound indices (US) in anticipation of the outcome of mechanical ventilation of pediatric patients in the intensive care unit. Methods This prospective study was conducted in Zagazig University, Pediatric Hospitals, PICU; Egypt. One hundred six mechanically ventilated children aged between 1 mo to 170 mo were included in the study. All patients were candidates for weaning and have been given a chance for spontaneous breathing trial (SBT), during which diaphragmatic and lung US was performed for them. The diaphragm thickening fraction (DTF), the diaphragmatic excursion and the lung US score (LUS), that included 4 US aeration forms, were assessed. Results There were statistically significant differences between patients with failed weaning and those with successful weaning regarding DTF, diaphragmatic excursion and LUS (p < 0.001). The best cut-off value of DTF, diaphragmatic excursion, and LUS for predicting weaning failure was ≥23.175%, ≥ 6.2 mm, and ≥ 12 with an AUC (area under curve) of 0.932, 0.876, and 0.934, respectively. Conclusions Diaphragmatic and lung US add a quick, accurate and non-invasive indices to the weaning readiness parameters compared to the other standard parameters alone. So, it is recommended to be added to the predictive parameters of weaning outcome.

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Section: Discussionmentioning

confidence: 99%