Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis

Kuenz, Bettina; Lutterotti, Andreas; Khalil, Michael; Ehling, Rainer; Gneiss, Claudia; Deisenhammer, Florian; Reindl, Markus; Berger, Thomas

doi:10.1016/j.jneuroim.2005.06.019

Cited by 57 publications

(40 citation statements)

References 31 publications

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“…Such an injury preceded other MRI abnormalities and the clinical evidence of a new lesion. This supports the view that a defect in the BBB, and therefore inflammation, is an early and possibly crucial event in the pathogenesis of a new lesion in MS. 25 Inflammation in MS is characterized by expression of adhesion molecules, 26 followed by a migration of macrophages and T-cells across the BBB. Infiltration of the matrix by macrophages, as in CVD, is considered a crucial step 27 ( Figure 3A and B).…”

Section: Parallels Between Inflammation In Cvd and In Msmentioning

confidence: 99%

The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis

Zamboni

2006

Journal of the Royal Society of Medicine

190

161

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Section: Parallels Between Inflammation In Cvd and In Msmentioning

confidence: 99%

The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis

Zamboni

2006

Journal of the Royal Society of Medicine

190

161

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“…An increase of serum levels of sPECAM-1 is well documented in MS (Losy et al, 1999;Jimenez et al, 2005;Minagar et al, 2001;Kuenz et al, 2005. ), although studies have not been able to link genetic changes in PECAM-1 with MS (Sciacca et al, 2000;Nelissen et al 2000.…”

Section: Discussionmentioning

confidence: 93%

Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms

Reinke

Lee

Zozulya

et al. 2007

Journal of Neuroimmunology

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The homotypic cell adhesion molecule PECAM-1 is a major participant in the migration of leukocytes across endothelium. We examined the ability of a chimeric soluble sPECAM-1 fused to human IgGFc to impair leukocyte entry through the blood-brain barrier and reduce CNS autoimmunity. sPECAM-Fc impaired migration of lymphocytes across brain endothelial monolayers and diminished the severity of EAE, an experimental model of MS, when administered at the onset of symptoms. However, in mice transgenic for sPECAM-Fc, the chronically elevated levels of sPECAM-Fc hastened onset of EAE disease without significantly changing clinical score severity. Our data suggests that short-term treatment of diseases like MS with sPECAM-Fc has therapeutic potential.

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“…Recently we observed a significant increase of soluble adhesion molecules (sPECAM-1, sP-Selectin and sE-Selectin) in RRMS patients compared to chronic progressive MS patients [112]. Furthermore soluble levels of sPECAM-1, sP-Selectin and sESelectin were increased during relapse, suggesting that these molecules might be useful paraclinical markers of disease activity in MS with restriction to the clinical course of the disease.…”

Section: Adhesion Moleculesmentioning

confidence: 91%

Biological Markers for Multiple Sclerosis

Lutterotti¹,

Berger²,

Reindl

2007

CMC

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Multiple sclerosis (MS) is the most common disabling neurological disease in young adults and is thought to result from an autoimmune attack against autoantigens within the myelin sheath. A characteristic feature of MS is the broad heterogeneity of clinical, histopathological and immunological phenotypes, which urges a more differentiated defining of patients by biological markers that reflect the underlying disease process and allow the prediction of disease courses and treatment responses. Here we review the current research on the identification of biomarkers for MS in cerebrospinal fluid and/or blood. We will focus on antibodies to myelin and non-myelin antigens, cells and soluble molecules of the immune system and the brain as biomarkers for 1) the diagnosis and prediction of clinical courses, 2) disease activity and 3) treatment response in MS.

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Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis

Cited by 57 publications

References 31 publications

The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis

The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis

Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms

Biological Markers for Multiple Sclerosis

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