Plasma levels of retinol and retinol-binding protein in patients with squamous cell carcinomas of the head and neck region

Bichler, E.

doi:10.1007/bf00454030

Cited by 9 publications

(10 citation statements)

References 31 publications

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“…In patients with head and neck tumors, we found serum vitamin A levels to be significantly lower compared to the controls [3]. Since we could demon strate that the dark adaption of such patients is distur bed, an effect which occurs only after vitamin A- deficiency of long duration, we assume that the lack of retinol was existent before tumor manifestation [4], The most common cause of decreased serum vitamin A levels is malnutrition [3]. Protein or retinol intake deficiency leads to a decrease of vitamin Atransporting protein and vitamin A serum levels.…”

Section: Discussionmentioning

confidence: 76%

“…It could be shown in experi ments that the incidence of chemically induced tumors is higher in the vitamin A-deficient state than in nor mally nourished animals [9], Kark et al [13] and Wald et al [33] demonstrated that patients with low retinol levels had a higher probability of developing cancer in later life. In patients with head and neck tumors, we found serum vitamin A levels to be significantly lower compared to the controls [3]. Since we could demon strate that the dark adaption of such patients is distur bed, an effect which occurs only after vitamin A- deficiency of long duration, we assume that the lack of retinol was existent before tumor manifestation [4], The most common cause of decreased serum vitamin A levels is malnutrition [3].…”

Section: Discussionmentioning

confidence: 99%

“…Since retinoic acid can not be converted to retinol but can perform some of its functions, it might be one of the active forms of the retinoids (name for retinol and derivatives) [9,22,29], Vitamin A (retinol) circulates in plasma bound to specific transport proteins, retinol-binding protein (RBP) and prealbumin (PALB). The levels of retinol, RBP and PALB were found to be diminished in several conditions such as malnutrition and disease of the liver [3,14,15,30]. Malignant tumors are often associated with reduced levels [3, 10.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin A Status and Retinoid-Binding Proteins in Carcinomas of the Head and Neck Region

Bichler¹,

Daxenbichler²,

Marth³

1983

Oncology

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The serum levels of retinol, RBP (retinol-binding protein) and PALB (prealbumin) were found to be significantly lower in patients with malignant tumors of the head and neck region than in controls. In tumor tissues as well in normal laryngeal mucosa, specific binding sites for retinol and retinoic acid were found. Whereas retinol-binding (CRBP = cellular retinol-binding protein) could only be detected in a few cases, binding for retinoic acid (CRABP = cellular retinoic acid-binding protein) was present in all specimens investigated. The presence or lack of binding sites was not dependent on the actual serum retinol levels. With regard to the antineoplastic role of vitamin A, the reduced serum levels are considered as a possible factor in tumor development and growth. CRBP and CRABP are assumed to be mediating factors for the retinol and retinoic acid action. Since the presence of CRABP is a constant finding, we propose that retinoic acid and its synthetic derivatives with high affinity for CRABP could be appropriate antineoplastic drugs in these tissues.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin A Status and Retinoid-Binding Proteins in Carcinomas of the Head and Neck Region

Bichler¹,

Daxenbichler²,

Marth³

1983

Oncology

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“…Sup port for this viewpoint comes front prospec tive studies by Wald et al [6], which showed lowered serum retinol levels in patients who subsequently developed lung cancer, and Bichler [9] who showed that patients with a variety of head and neck squamous carcino mas and low'er pretreatment scrum retinol levels, compared with controls, retained their lower levels after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies on vitamin A and cancer have concerned the larynx, and those that have did not indicate the stage or classification of the tumours [8,9], The present study is restricted to small untreated tumours of the larynx. These arc not associated with the production of bioac tive peptides capable of affecting metabo lism.…”

Section: Introductionmentioning

confidence: 99%

Serum Vitamin A Levels in Patients with Untreated T<sub>1</sub> or T<sub>2</sub> Squamous Carcinoma of the Larynx: a Pilot Study

Mugliston

Coe

1986

ORL

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The serum retinol levels of 19 patients with T₁ or T₂ tumours of the larynx were compared with those of non-malignant smoking and non-malignant non-smoking controls matched for age, sex and weight. The cancer group had a significantly lower level of serum retinol than either control group between which there was no significant difference. It is unlikely that the lower serum retinol levels were due to either tumour or cigarette smoke.

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Retinoids in Cancer Treatment

Tallman

Wiernik

1992

The Journal of Clinical Pharma

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Since initial studies identifying the important role of vitamin A and its derivatives (retinoids) in maintaining the integrity of epithelial tissues, these compounds have served as paradigms for experimental studies exploring the pharmacologic modification of carcinogenesis. Retinoids have clearly been shown to inhibit chemically induced mammary and urothelial carcinogenesis in experimental animals. Prohibitive toxicity of the parent compound, vitamin A, led to a systematic search for synthetic derivatives with an improved therapeutic index. More than 1500 such compounds have been synthesized, many retaining chemopreventive potential, but with less toxicity. Although several anecdotal reports confirming therapeutic benefits of cis-retinoic acid in patients with acute promyelocytic leukemia and myelodysplastic syndromes appeared in the late 1970s and early 1980s, the remarkable studies of Huang and his colleagues in China in 1988 reporting complete remissions in patients with this uncommon variety of acute myelogenous leukemia with the transisomer of retinoic acid (all-trans-retinoic acid) led to a resurgence of interest in the retinoids as differentiating agents for the prevention and therapy of cancer. Furthermore, molecular studies showing DNA rearrangements of the alpha nuclear receptor for retinoic acid located on chromosome 17 in patients with acute promyelocytic leukemia, a disease invariably associated with a translocation between chromosomes 15 and 17, provided a direct connection between an altered nuclear receptor and the development of a human malignancy. The retinoids also may have important beneficial effects in prevention of recurrent malignancies once the primary tumor has been treated, such as in squamous cell carcinoma of the head and neck. Because retinoids appear to be less effective in inducing differentiation in nonpromyelocytic leukemia cells, investigators have conducted a number of studies to exploit potential synergism between retinoids and other differentiating agents or biologic effectors. Differentiation therapy and chemoprevention are attractive alternative approaches to intensive cytotoxic chemotherapy. It is now clear that retinoids represent one class of compounds with which it may be possible to reverse the progression of malignant disease and prevent carcinogenesis.

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Plasma levels of retinol and retinol-binding protein in patients with squamous cell carcinomas of the head and neck region

Cited by 9 publications

References 31 publications

Vitamin A Status and Retinoid-Binding Proteins in Carcinomas of the Head and Neck Region

Vitamin A Status and Retinoid-Binding Proteins in Carcinomas of the Head and Neck Region

Serum Vitamin A Levels in Patients with Untreated T<sub>1</sub> or T<sub>2</sub> Squamous Carcinoma of the Larynx: a Pilot Study

Retinoids in Cancer Treatment

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